Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2008 2
2009 2
2011 1
2023 1
2024 1
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

8 results

Results by year

Filters applied: . Clear all
Quoted phrase not found in phrase index: "Impaired binding of factor VIII to VWF"
Page 1
The role of VWF in the immunogenicity of FVIII.
Lacroix-Desmazes S, Repessé Y, Kaveri SV, Dasgupta S. Lacroix-Desmazes S, et al. Thromb Res. 2008;122 Suppl 2:S3-6. doi: 10.1016/S0049-3848(08)70002-1. Thromb Res. 2008. PMID: 18549909 Review.
Up to 33% of patients with severe haemophilia A develop inhibitory antibodies to factor VIM (FVIII) that can significantly impair treatment with FVIII. The plasma protein von Willebrand factor (VWF) binds to FVIII and is known to be important fo …
Up to 33% of patients with severe haemophilia A develop inhibitory antibodies to factor VIM (FVIII) that can significantly impair …
Periprocedural management of type 2N von Willebrand disease with efanesoctocog alfa.
Ryu JH, Bauer KA, Schulman S. Ryu JH, et al. J Thromb Haemost. 2023 Dec;21(12):3508-3510. doi: 10.1016/j.jtha.2023.09.009. Epub 2023 Sep 20. J Thromb Haemost. 2023. PMID: 37734716 Free article.
Type 2 Normandy von Willebrand disease (type 2N VWD) is a rare qualitative defect in von Willebrand factor (VWF) that results in impaired factor VIII (FVIII) binding and consequently reduced FVIII levels. ...By decoupling the FVIII-VWF …
Type 2 Normandy von Willebrand disease (type 2N VWD) is a rare qualitative defect in von Willebrand factor (VWF) that results …
Factor VIII-von Willebrand factor binding defects in autosomal recessive von Willebrand disease type Normandy and in mild hemophilia A. New insights into factor VIII-von Willebrand factor interactions.
Jacquemin M. Jacquemin M. Acta Haematol. 2009;121(2-3):102-5. doi: 10.1159/000214849. Epub 2009 Jun 8. Acta Haematol. 2009. PMID: 19506355 Review.
This concise review is focused on genetic, molecular and clinical aspects of von Willebrand disease (VWD) type 2N and of mild hemophilia A due to mutations impairing FVIII-von Willebrand factor (VWF) interactions. Missense mutations in the VWF g …
This concise review is focused on genetic, molecular and clinical aspects of von Willebrand disease (VWD) type 2N and of mild hemophi …
Recessive von Willebrand disease type 2 Normandy: variable expression of mild hemophilia and VWD type 1.
Michiels JJ, Gadisseur A, Vangenegten I, Schroyens W, Berneman Z. Michiels JJ, et al. Acta Haematol. 2009;121(2-3):119-27. doi: 10.1159/000214852. Epub 2009 Jun 8. Acta Haematol. 2009. PMID: 19506358 Review.
Missense mutations in the von Willebrand factor (VWF) gene impairing the binding to factor VIII (FVIII) do not impair the structure of VWF multimers nor the ability of VWF to aggregate platelets but causes an accelera …
Missense mutations in the von Willebrand factor (VWF) gene impairing the binding to factor VIII (F …
Patients with severe aortic valve stenosis and impaired platelet function benefit from preoperative desmopressin infusion.
Steinlechner B, Zeidler P, Base E, Birkenberg B, Ankersmit HJ, Spannagl M, Quehenberger P, Hiesmayr M, Jilma B. Steinlechner B, et al. Ann Thorac Surg. 2011 May;91(5):1420-6. doi: 10.1016/j.athoracsur.2011.01.052. Epub 2011 Mar 24. Ann Thorac Surg. 2011. PMID: 21439546 Clinical Trial.
We hypothesized that such patients may benefit from desmopressin when they present with prolonged CADP-CT due to the specific action of desmopressin on von Willebrand factor (VWF) and CADP-CT. METHODS: In this double-blind, randomized placebo controlled tr …
We hypothesized that such patients may benefit from desmopressin when they present with prolonged CADP-CT due to the specific action of desm …
The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study.
Chan CHH, Passmore MR, Tronstad O, Seale H, Bouquet M, White N, Teruya J, Hogan A, Platts D, Chan W, Dashwood AM, McGiffin DC, Maiorana AJ, Hayward CS, Simmonds MJ, Tansley GD, Suen JY, Fraser JF, Meyns B, Fresiello L, Jacobs S. Chan CHH, et al. ASAIO J. 2025 Jan 1;71(1):11-20. doi: 10.1097/MAT.0000000000002246. Epub 2024 Jun 4. ASAIO J. 2025. PMID: 38833540
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). ...Acute exercise resulted in an increased platelet cou …
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) b …
Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease.
Geisen U, Heilmann C, Beyersdorf F, Benk C, Berchtold-Herz M, Schlensak C, Budde U, Zieger B. Geisen U, et al. Eur J Cardiothorac Surg. 2008 Apr;33(4):679-84. doi: 10.1016/j.ejcts.2007.12.047. Epub 2008 Feb 20. Eur J Cardiothorac Surg. 2008. PMID: 18282712
Impaired coagulation associated with VADs was also reflected by the diminished ratios of collagen binding capacity and ristocetin cofactor activity to VWF antigen. ...Several pharmacologic treatment options (tranexamic acid, desmopressin, VWF-factor …
Impaired coagulation associated with VADs was also reflected by the diminished ratios of collagen binding capacity and ristoce …
Diagnosis of von Willebrand disease.
Ingerslev J, Gürsel T. Ingerslev J, et al. Haemophilia. 1999 May;5 Suppl 2:50-6. doi: 10.1046/j.1365-2516.1999.0050s2050.x. Haemophilia. 1999. PMID: 23401900
The haemorrhagic diathesis in von Willebrand disease (vWD) is caused by a quantitative deficiency or a qualitative defect in the von Willebrand factor (vWF) in plasma and/or platelets causing insufficient primary haemostasis. Since vWF binds and protec …
The haemorrhagic diathesis in von Willebrand disease (vWD) is caused by a quantitative deficiency or a qualitative defect in the von Willebr …