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Year Number of Results
2009 18
2010 115
2011 124
2012 176
2013 240
2014 234
2015 258
2016 300
2017 376
2018 412
2019 124
2020 0
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2,154 results
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Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9.
Ben Jehuda R, et al. Stem Cell Rev Rep 2018 - Review. PMID 29623532
The development of the reprogramming technology led to generation of induced Pluripotent Stem Cells (iPSC) from a variety of somatic cells. ...Indeed, iPSC-derived cells have been increasingly used for investigating molecular and cellular pathophysiological mechanisms underlying inherited diseases. ...
The development of the reprogramming technology led to generation of induced Pluripotent Stem Cells (iPSC) from …
Induced Pluripotent Stem Cells Meet Genome Editing.
Hockemeyer D and Jaenisch R. Cell Stem Cell 2016 - Review. PMID 27152442 Free PMC article.
Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. ...
Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the …
Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.
Paik DT, et al. Circ Res 2018. PMID 29986945 Free PMC article.
RATIONALE: Human-induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool in cardiovascular research, offering a wide gamut of translational and clinical applications. ...Nonendothelial cell populations resulting from the differentiation protocol were identified, which included immature cardiomyocytes, hepatic-like cells, and vascular smooth muscle cells. ...
RATIONALE: Human-induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool …
Present and future challenges of induced pluripotent stem cells.
Ohnuki M and Takahashi K. Philos Trans R Soc Lond B Biol Sci 2015 - Review. PMID 26416678 Free PMC article.
However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined transcription factors. The discovery of this induced pluripotent stem cell (iPSC) technology has opened up unprecedented opportunities in regenerative medicine, disease modelling and drug discovery. ...
However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency whic …
Epigenetic memory in induced pluripotent stem cells.
Kim K, et al. Nature 2010. PMID 20644535 Free PMC article.
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. ...In contrast, the differentiation and methylation of nuclear-transfer-derived pluripotent stem cells were more similar to classical embryonic stem cells than were iPSCs. ...
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield plu
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, et al. Int J Mol Sci 2018 - Review. PMID 30513688 Free PMC article.
In this review, we discuss findings from induced pluripotent stem cells (iPSCs) that allow the generation of disease-relevant cell types from early brain development. ...Interestingly, transcriptional signatures of iPSC-derived cells from patients with COS showed concordance with postmortem brain samples from SCZ, indicating that changes in vitro may recapitulate changes from the diseased brain. ...
In this review, we discuss findings from induced pluripotent stem cells (iPSCs) that allow the generation of dis …
Generation of functional podocytes from human induced pluripotent stem cells.
Ciampi O, et al. Stem Cell Res 2016. PMID 27299470 Free PMC article.
Here, we describe a simple and efficient protocol for obtaining functional podocytes in vitro from human induced pluripotent stem cells. Cells were exposed to a three-step protocol, which induced their differentiation into intermediate mesoderm, then into nephron progenitors and, finally, into mature podocytes. ...
Here, we describe a simple and efficient protocol for obtaining functional podocytes in vitro from human induced pluripotent
Endogenous Protein Tagging in Human Induced Pluripotent Stem Cells Using CRISPR/Cas9.
Haupt A, et al. J Vis Exp 2018. PMID 30199041 Free PMC article.
A protocol is presented for generating human induced pluripotent stem cells (hiPSCs) that express endogenous proteins fused to in-frame N- or C-terminal fluorescent tags. ...Putatively edited cells expressing the fluorescently tagged proteins are enriched by fluorescence activated cell sorting (FACS). ...
A protocol is presented for generating human induced pluripotent stem cells (hiPSCs) that express endogenous pro …
Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells.
Noguchi H, et al. Int J Mol Sci 2018 - Review. PMID 29561778 Free PMC article.
Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells. ...Our recent study demonstrated the generation of induced tissue-specific stem (iTS) cells by transient overexpression of the reprogramming factors combined with tissue-specific selection. iTS cells are cells that inherit numerous components of epigenetic memory from donor tissue and acquire self-renewal potential. ...
Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues ass
Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells.
Onozato D, et al. Drug Metab Dispos 2018. PMID 29615438
In this study, we aimed to generate pharmacokinetically functional intestinal organoids from human induced pluripotent stem (iPS) cells. ...Exposure to the small-molecule compounds potently increased the expression of intestinal markers and pharmacokinetic-related genes in the organoids, and the organoids also included various intestinal cells such as enterocytes, intestinal stem cells, goblet cells, enteroendocrine cells, Paneth cells, smooth muscle cells, and fibroblasts. ...
In this study, we aimed to generate pharmacokinetically functional intestinal organoids from human induced pluripotent stem
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