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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 26
1946 99
1947 127
1948 135
1949 142
1950 212
1951 258
1952 261
1953 322
1954 387
1955 306
1956 323
1957 289
1958 310
1959 339
1960 296
1961 330
1962 365
1963 684
1964 961
1965 734
1966 940
1967 1153
1968 1512
1969 1699
1970 1756
1971 1913
1972 2101
1973 2132
1974 2273
1975 2121
1976 2209
1977 2161
1978 2232
1979 2576
1980 2761
1981 2761
1982 2900
1983 2952
1984 3047
1985 3057
1986 2991
1987 2926
1988 3126
1989 3087
1990 3303
1991 3269
1992 3241
1993 3326
1994 3354
1995 3327
1996 3309
1997 3438
1998 3403
1999 3295
2000 3537
2001 3682
2002 4027
2003 3991
2004 4346
2005 4648
2006 5000
2007 5041
2008 5359
2009 5807
2010 5666
2011 5509
2012 5645
2013 5726
2014 5626
2015 5566
2016 5517
2017 5290
2018 4601
2019 2010
2020 26
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182,637 results
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Page 1
[Insulin therapy-new insulin analogues].
Ehren M and Klein HH. Internist (Berl) 2019 - Review. PMID 31396651 German.
A multitude of short-acting and long-acting insulin analogues are currently available for the treatment of diabetes mellitus, which mimic physiological insulin secretion better than normal insulins. ...Future developments focus on a further acceleration of prandial insulin effects with a simultaneous shorter effect time and an even more prolonged action of long-acting insulin analogues....
A multitude of short-acting and long-acting insulin analogues are currently available for the treatment of diabetes mellitus, which m …
Insulin: a review of analytical methods.
Shen Y, et al. Analyst 2019 - Review. PMID 31143899
Insulin is an important polypeptide hormone that regulates carbohydrate metabolism. Abnormal levels of insulin are associated with diabetes mellitus that is characterized by chronic hyperglycemia. Therefore, reliable quantification of insulin is important for clinical purposes such as the diagnosis and treatment of diabetes. ...
Insulin is an important polypeptide hormone that regulates carbohydrate metabolism. Abnormal levels of insulin are associated
Developing Insulin and BDNF Mimetics for Diabetes Therapy.
Chan CB, et al. Curr Top Med Chem 2019 - Review. PMID 31660832
The general principle of current therapeutic strategies for patients with T2DM mainly focuses on restoring cellular insulin response by potentiating the insulin-induced signaling pathway. In late-stage T2DM, impaired insulin production requires the patients to receive insulin replacement therapy for maintaining their glucose homeostasis. ...
The general principle of current therapeutic strategies for patients with T2DM mainly focuses on restoring cellular insulin response …
The Insulin/IGF System in Mammalian Sexual Development and Reproduction.
Neirijnck Y, et al. Int J Mol Sci 2019 - Review. PMID 31505893 Free PMC article.
Persistent research over the past few decades has clearly established that the insulin-like family of growth factors, which is composed of insulin and insulin-like growth factors 1 (IGF1) and 2 (IGF2), plays essential roles in sexual development and reproduction of both males and females. ...In this review, we first briefly outline the principles of sexual development and insulin/IGF signaling, and then present our current knowledge, both in rodents and humans, about the involvement of insulin/IGFs in sexual development and reproductive functions. ...
Persistent research over the past few decades has clearly established that the insulin-like family of growth factors, which is compos …
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
Mitrofanova A, et al. Nat Commun 2019. PMID 31217420 Free PMC article.
Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding to caveolin-1 in the PM. ...Taken together, we identify SMPDL3b as a modulator of insulin signaling and demonstrate that supplementation with exogenous C1P may represent a lipid therapeutic strategy to treat diabetic complications such as DKD....
Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dep …
Insulin pump therapy: education and its goals.
Štechová K. Vnitr Lek 2019. PMID 31091943
Insulin pump therapy represents nowadays the way of insulin administration most similar to the physiological insulin secretion. This form of intensified insulin regime is used mostly (but not exclusively) in type 1 diabetes patients. Insulin pump therapy can be efficiently combined with continuous glucose monitoring. ...
Insulin pump therapy represents nowadays the way of insulin administration most similar to the physiological insulin se
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.
Oh Y, et al. Nature 2019. PMID 31645735 Free PMC article.
One axon branch projects to insulin-producing cells to trigger the release of Drosophila insulin-like peptide 2 (dilp2) and the other extends to adipokinetic hormone (AKH)-producing cells to inhibit secretion of AKH, the fly analogue of glucagon. ...Silencing of these glucose-sensing neurons largely disabled the response of insulin-producing cells to glucose and dilp2 secretion, disinhibited AKH secretion in corpora cardiaca and caused hyperglycaemia, a hallmark feature of diabetes mellitus. ...
One axon branch projects to insulin-producing cells to trigger the release of Drosophila insulin-like peptide 2 (dilp2) and th …
Advanced biosensors for glucose and insulin.
Sabu C, et al. Biosens Bioelectron 2019 - Review. PMID 31302426
Insulin plays a major role in glucose metabolism and its determination is of great value in the diagnosis and control of diabetes. ...Here, we have reviewed the fabrication, modification, and recent approaches associated with insulin and glucose biosensors for the treatment of diabetes....
Insulin plays a major role in glucose metabolism and its determination is of great value in the diagnosis and control of diabetes. ..
HMGB1 inhibits insulin signalling through TLR4 and RAGE in human retinal endothelial cells.
Jiang Y and Steinle JJ. Growth Factors 2018. PMID 31084273 Free PMC article.
Little is available on high mobility group box 1 (HMGB1) actions on the proteins involved in insulin signal transduction, which may be altered to result in insulin resistance in the retina. ...Epac1 overcame both endogenous and exogenous HMGB1 to maintain normal insulin signalling. Taken together, these data offer upstream targets to maintain proper insulin signal transduction in the retinal vasculature....
Little is available on high mobility group box 1 (HMGB1) actions on the proteins involved in insulin signal transduction, which may b …
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