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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2006 5
2007 13
2008 27
2009 35
2010 34
2011 39
2012 57
2013 48
2014 69
2015 63
2016 44
2017 37
2018 29
2019 14
2020 1
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453 results
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Page 1
Natural Killer Cells: Development, Maturation, and Clinical Utilization
Abel AM, et al. Front Immunol 2018 - Review. PMID 30150991 Free PMC article.
NK cells do not express polymorphic clonotypic receptors and utilize inhibitory receptors (killer immunoglobulin-like receptor and Ly49) to develop, mature, and recognize "self" from "non-self." The essential roles of common gamma cytokines such as interleukin (IL)-2, IL-7, and IL-15 in the commitment and development of NK cells are well established. ...
NK cells do not express polymorphic clonotypic receptors and utilize inhibitory receptors (killer immunoglobulin-like receptor and Ly …
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications
Leonard WJ, et al. Immunity 2019 - Review. PMID 30995502
The common cytokine receptor γ chain, γ(c), is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. ...
The common cytokine receptor γ chain, γ(c), is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, …
Humanized mice for immune system investigation: progress, promise and challenges
Shultz LD, et al. Nat Rev Immunol 2012 - Review. PMID 23059428 Free PMC article.
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. ...
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from …
Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
De Ravin SS, et al. Sci Transl Med 2016 - Clinical Trial. PMID 27099176 Free PMC article.
X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and natural killer (NK) cell immunity caused by mutations inIL2RGencoding the common chain (γc) of several interleukin receptors. Gamma-retroviral (γRV) gene therapy of SCID-X1 infants without conditioning restores T cell immunity without B or NK cell correction, but similar treatment fails in older SCID-X1 children. ...
X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and natural killer (NK) cell immunity caused by mutati …
A versatile system for rapid multiplex genome-edited CAR T cell generation
Ren J, et al. Oncotarget 2017. PMID 28199983 Free PMC article.
The therapeutic potential of CRISPR system has already been demonstrated in many instances and begun to overlap with the rapidly expanding field of cancer immunotherapy, especially on the production of genetically modified T cell receptor or chimeric antigen receptor (CAR) T cells. ...
The therapeutic potential of CRISPR system has already been demonstrated in many instances and begun to overlap with the rapidly expanding f …
The common γ-chain cytokine receptor: tricks-and-treats for T cells.
Waickman AT, et al. Cell Mol Life Sci 2016 - Review. PMID 26468051 Free PMC article.
Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also acts as a non-redundant receptor subunit for a series of other cytokines, collectively known as γc family cytokines. γc plays essential roles in T cell development and differentiation, so that understanding the molecular basis of its signaling and regulation is a critical issue in T cell immunology. ...Cytokine-independent binding of γc to other cytokine receptor subunits suggested a pre-association model of γc with proprietary cytokine receptors. ...
Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also act …
A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk.
Gonnord P, et al. Sci Signal 2018. PMID 29615515
Cytokines belonging to the common gamma chain (γ(c)) family depend on the shared γ(c) receptor subunit for signaling. We report the existence of a fast, cytokine-induced pathway cross-talk acting at the receptor level, resulting from a limiting amount of γ(c) on the surface of T cells. We found that this limited abundance of γ(c) reduced interleukin-4 (IL-4) and IL-21 responses after IL-7 preexposure but not vice versa. ...
Cytokines belonging to the common gamma chain (γ(c)) family depend on the shared γ(c) receptor subunit for signa …
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