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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 9
2002 62
2003 64
2004 83
2005 94
2006 91
2007 113
2008 114
2009 116
2010 89
2011 112
2012 114
2013 114
2014 81
2015 101
2016 66
2017 64
2018 47
2019 29
2020 0
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1,380 results
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Page 1
The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit.
Garnier P, et al. Cytokine 2018. PMID 29753267 Free PMC article.
We have previously shown that the heterodimeric cytokine interleukin-12, and the homodimer of its larger subunit p40, both bind to heparin and heparan sulfate with relatively high affinity. ...Human interleukin-12 and p40 homodimer show indistinguishable binding profiles with a panel of heparin derivatives, but that of murine interleukin-12 is distinct. ...
We have previously shown that the heterodimeric cytokine interleukin-12, and the homodimer of its larger subunit p40, both bind to he …
Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment.
Johansson P, et al. PLoS One 2017. PMID 28464009 Free PMC article.
Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A), and three chemokines were measured using a multiplex panel. ...
Serum and CSF concentrations of interleukin-6 (IL-6), IL-8, IL-12/23 p40, IL-15, IL-16, vascular endothelial growth factor-A (VEGF-A) …
Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
Sharma N, et al. Arterioscler Thromb Vasc Biol 2019. PMID 30580570 Free PMC article.
Using IL12p40(-/-) (interleukin 12 p40) mice, we investigated the effects of M2-predominant macrophages on the development of abdominal aortic aneurysm. ...
Using IL12p40(-/-) (interleukin 12 p40) mice, we investigated the effects of M2-predominant macrophages on the development of abdomin …
Differential expression of interleukin-12 p35 and p40 subunits in response to Aeromonas hydrophila and Aquareovirus infection in grass carp, Ctenopharyngodon idella.
Pandit NP, et al. Genet Mol Res 2015. PMID 25730056 Free article.
In this study, the involvement of interleukin-12 (IL-12) from grass carp (gcIL‑12) in anti-bacterial and anti-viral immune responses was demonstrated via expression profiles of gcIL-12 subunits in immune tissues of the fish, following infection by Aeromonas hydrophila and Aquareovirus. ...
In this study, the involvement of interleukin-12 (IL-12) from grass carp (gcIL‑12) in anti-bacterial and anti-viral immune responses …
Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease.
Deepak P and Sandborn WJ. Gastroenterol Clin North Am 2017 - Review. PMID 28838418
The article also enumerates drugs that are specific interleukin-23 blockers, including brazikumab (MEDI2070), risankizumab, LY3074828, tildrakizumab, and guselkumab, and the current status of their clinical trials....
The article also enumerates drugs that are specific interleukin-23 blockers, including brazikumab (MEDI2070), risankizumab, LY3074828 …
IL-12-and IL-23 in health and disease
Croxford AL, et al. Cytokine Growth Factor Rev 2014 - Review. PMID 25130295
Interleukin (IL)-12 and IL-23 play important roles in the development of experimental autoimmune disease models and numerous afflictions affecting humans. ...
Interleukin (IL)-12 and IL-23 play important roles in the development of experimental autoimmune disease models and numerous afflicti
Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women
Nikołajuk A, et al. Metab Syndr Relat Disord 2015. PMID 26038987
Interleukin-12 (IL-12) is a proinflammatory cytokine composed of a 40-kD (p40) subunit and a 35-kD (p35) subunit. p40 might have an independent role in initiating the immune response. ...
Interleukin-12 (IL-12) is a proinflammatory cytokine composed of a 40-kD (p40) subunit and a 35-kD (p35) subunit. p40 might have an i
Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12.
Bootz F, et al. Protein Eng Des Sel 2016. PMID 27515704 Free PMC article.
In this article, we have analyzed biochemical and pharmaceutical properties of fusion proteins, consisting of the F8 antibody (specific to the EDA domain of fibronectin, a marker of tissue remodeling and of angiogenesis) and of the p40 subunit of interleukin-12, an inhibitor of inflammation. ...
In this article, we have analyzed biochemical and pharmaceutical properties of fusion proteins, consisting of the F8 antibody (specific to t …
Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Maxwell JR, et al. Immunity 2015. PMID 26431947 Free article.
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn's disease. ...
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cyto
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