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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 3
1995 22
1996 51
1997 61
1998 93
1999 98
2000 113
2001 128
2002 138
2003 138
2004 140
2005 156
2006 167
2007 182
2008 184
2009 184
2010 176
2011 190
2012 186
2013 177
2014 196
2015 161
2016 166
2017 141
2018 144
2019 48
2020 1
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3,103 results
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Interleukin 15: A key cytokine for immunotherapy.
Patidar M, et al. Cytokine Growth Factor Rev 2016 - Review. PMID 27325459
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. ...In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway....
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential.
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Burrack KS, et al. Immunity 2018. PMID 29625893 Free PMC article.
We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expanded natural killer (NK) cells were necessary and sufficient for protection against ECM. ...
We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expa …
Culturing the Human Natural Killer Cell Line NK-92 in Interleukin-2 and Interleukin-15 - Implications for Clinical Trials.
Törnroos H, et al. Anticancer Res 2019. PMID 30591446
Herein, NK-92 cells were analyzed with respect to their proliferation and cytotoxicity, in the presence of interleukin-2 (IL-2) and interleukin-15 (IL-15). ...RESULTS: IL-2 and IL-15, but not IL-4 or IL-7, were able to induce a dose-dependent proliferation of NK-92 cells. IL-15 was, depending on the dose and culture time, up to 10 times more potent compared to corresponding concentrations of IL-2, whereas their combination could potentiate the NK-activity almost equally well. ...
Herein, NK-92 cells were analyzed with respect to their proliferation and cytotoxicity, in the presence of interleukin-2 (IL-2) and …
Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo.
Garrido C, et al. J Virol 2018. PMID 29593039 Free PMC article.
We assessed the impact of interleukin 15 (IL-15) treatment on NK cell function and the potential for stimulated NK cells to clear the HIV reservoir. ...All NK cell functions were uniformly improved by IL-15, and, more importantly, IL-15-treated NK cells were able to clear latently HIV-infected cells after exposure to vorinostat, a clinically relevant latency-reversing agent. ...
We assessed the impact of interleukin 15 (IL-15) treatment on NK cell function and the potential for stimulated NK cell …
Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors.
Kang X, et al. Cell Commun Signal 2018. PMID 30029643 Free PMC article.
We screened the potential myokines and found Interleukin-15 (IL-15) may regulate the fatty infiltration in muscle injury. In this study, we investigated how IL-15 regulated FAPs in muscle injury and the effect on muscle regeneration. ...The growth of FAPs caused by IL-15 was mediated through JAK-STAT pathway. In addition, desert hedgehog pathway may participate in IL-15 inhibiting adipogenesis of FAPs. ...
We screened the potential myokines and found Interleukin-15 (IL-15) may regulate the fatty infiltration in muscle injur …
The role of exercise-induced myokines in regulating metabolism
Huh JY. Arch Pharm Res 2018 - Review. PMID 29177585
In the past few decades, a number of myokines have been discovered, such as interleukin-6, irisin, myostatin, interleukin-15, brain-derived neurotrophic factor, β-aminoisobutyric acid, meteorin-like, leukemia inhibitory factor, and secreted protein acidic and rich in cysteine, through secretome analysis. ...
In the past few decades, a number of myokines have been discovered, such as interleukin-6, irisin, myostatin, interleukin-1
Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis.
Bellelis P, et al. Gynecol Obstet Invest 2019. PMID 30712043
MAIN OUTCOME MEASURES: Interleukin (IL)-2, IL-4, IL-7, IL-10, IL-12, IL-15, transforming growth factor β1, and IFNγ concentration was measured using a LuminexTM multiplex suspension bead array. ...In PB, compared to endometriosis group, IL-4, IL-10, IL-12, IL-15, and IFNγ concentrations were significantly higher in the control group (p < 0.05). ...
MAIN OUTCOME MEASURES: Interleukin (IL)-2, IL-4, IL-7, IL-10, IL-12, IL-15, transforming growth factor β1, and IFNγ concentrat …
Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.
Kochenderfer JN, et al. J Clin Oncol 2017. PMID 28291388 Free PMC article.
The low-dose chemotherapy conditioning regimen depleted blood lymphocytes and increased serum interleukin-15 (IL-15). Patients who achieved a remission had a median peak blood CAR(+) cell level of 98/μL and those who did not achieve a remission had a median peak blood CAR(+) cell level of 15/μL ( P = .027). High serum IL-15 levels were associated with high peak blood CAR(+) cell levels ( P = .001) and remissions of lymphoma ( P < .001). ...
The low-dose chemotherapy conditioning regimen depleted blood lymphocytes and increased serum interleukin-15 (IL-15). P …
Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity.
Li M, et al. Proc Natl Acad Sci U S A 2017. PMID 27994144 Free PMC article.
Here we found that interleukin-15 (IL-15) is dramatically up-regulated in astrocytes of postmortem brain tissues from patients with ischemic stroke and in a mouse model of transient focal brain ischemia. ...Of note, depletion of CD8(+) T or NK cells attenuated ischemic brain injury in GFAP-IL-15(tg) mice. Furthermore, knockdown of the IL-15 receptor α or blockade of cell-to-cell contact diminished the activation and effector function of CD8(+) T and NK cells in GFAP-IL-15(tg) mice, suggesting that astrocytic IL-15 is delivered in trans to target cells. ...
Here we found that interleukin-15 (IL-15) is dramatically up-regulated in astrocytes of postmortem brain tissues from p …
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.
Liu E, et al. Leukemia 2018. PMID 28725044 Free PMC article.
We transduced CB-derived NK cells with a retroviral vector incorporating the genes for CAR-CD19, IL-15 and inducible caspase-9-based suicide gene (iC9), and demonstrated efficient killing of CD19-expressing cell lines and primary leukemia cells in vitro, with marked prolongation of survival in a xenograft Raji lymphoma murine model. Interleukin-15 (IL-15) production by the transduced CB-NK cells critically improved their function. Moreover, iC9/CAR.19/IL-15 CB-NK cells were readily eliminated upon pharmacologic activation of the iC9 suicide gene. ...
We transduced CB-derived NK cells with a retroviral vector incorporating the genes for CAR-CD19, IL-15 and inducible caspase-9-based …
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