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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 4
1979 1
1980 14
1981 16
1982 49
1983 88
1984 142
1985 231
1986 231
1987 195
1988 114
1989 107
1990 85
1991 86
1992 113
1993 116
1994 117
1995 96
1996 87
1997 113
1998 93
1999 124
2000 117
2001 109
2002 107
2003 118
2004 132
2005 129
2006 161
2007 157
2008 185
2009 203
2010 184
2011 220
2012 218
2013 163
2014 195
2015 174
2016 156
2017 149
2018 122
2019 58
2020 0
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5,012 results
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Page 1
Interleukin-2: Biology, Design and Application.
Arenas-Ramirez N, et al. Trends Immunol 2015 - Review. PMID 26572555 Free article.
Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte responses. ...
Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimiz
Overview of interleukin-2 function, production and clinical applications.
Gaffen SL and Liu KD. Cytokine 2004 - Review. PMID 15473953
The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one of the most extensively studied cytokines. ...
The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one of the most extensively studied cytokin …
IL-2 and Beyond in Cancer Immunotherapy
Wrangle JM, et al. J Interferon Cytokine Res 2018 - Review. PMID 29443657 Free PMC article.
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act
Kalia V and Sarkar S. Front Immunol 2018 - Review. PMID 30619342 Free PMC article.
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology-signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. ...
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology-signaling through distinct pathways IL-2 triggers critical metabolic
Clinical Relevance of Autoantibodies against Interleukin-2 in Patients with Systemic Lupus Erythematosus.
Shao M, et al. Chin Med J (Engl) 2018. PMID 29941704 Free PMC article.
BACKGROUND: Increased serum autoantibodies against interleukin-2 (anti-IL-2 autoantibodies) were reported in patients with systemic lupus erythematosus (SLE) and in patients receiving IL-2 therapy. ...
BACKGROUND: Increased serum autoantibodies against interleukin-2 (anti-IL-2 autoantibodies) were reported in patients with systemic l …
New therapeutic strategies based on IL-2 to modulate Treg cells for autoimmune diseases
Xu L, et al. Int Immunopharmacol 2019 - Review. PMID 31005777
Interleukin-2 (IL-2) is a multifunctional cytokine in immune regulation. It is essential for the differentiation, expansion and stability of CD25(+)Foxp3(+) regulatory T (Treg) cells, which is an important factor in immune suppression and self-tolerance. ...
Interleukin-2 (IL-2) is a multifunctional cytokine in immune regulation. It is essential for the differentiation, expansion and stabi
Interleukin-2 and interleukin-15: immunotherapy for cancer.
Fehniger TA, et al. Cytokine Growth Factor Rev 2002 - Review. PMID 11900992
Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell carcinoma and malignant melanoma demonstrated the first efficacy for cytokine monotherapy in the treatment of neoplastic disease. ...
Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function and homeostasis. Early clinical intere
Local Interleukin-2 Immunotherapy of Breast Cancer: Benefit and Risk in a Spontaneous Mouse Model.
Semushina SG, et al. Pathol Oncol Res 2019. PMID 29511983
Then we advanced a novel 3S-paradigm of anticancer research that helped to develop selection criteria and to estimate benefit/risk of local interleukin-2 (IL-2) effects in this spontaneous mouse model. ...
Then we advanced a novel 3S-paradigm of anticancer research that helped to develop selection criteria and to estimate benefit/risk of local …
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