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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 6
1990 53
1991 87
1992 193
1993 222
1994 299
1995 294
1996 304
1997 400
1998 380
1999 415
2000 473
2001 494
2002 533
2003 646
2004 613
2005 740
2006 773
2007 843
2008 961
2009 1017
2010 1083
2011 1147
2012 1230
2013 1307
2014 1340
2015 1284
2016 1139
2017 1043
2018 954
2019 427
2020 6
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18,352 results
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Page 1
Interleukin-6 for early diagnosis of neonatal sepsis with premature rupture of the membranes: A meta-analysis.
Qiu X, et al. Medicine (Baltimore) 2018 - Review. PMID 30461611 Free PMC article.
Interleukin-6 (IL-6) has been investigated for early diagnosis of neonatal sepsis, but not for diagnosis of neonatal sepsis with PROM. ...CONCLUSION: IL-6 is therefore a sensitive and specific diagnostic marker for the early diagnosis of neonatal sepsis with PROM....
Interleukin-6 (IL-6) has been investigated for early diagnosis of neonatal sepsis, but not for diagnosis of neonatal se
Interleukin-6 and cardiac operations.
Yuan SM. Eur Cytokine Netw 2018 - Review. PMID 29748154
Interleukin (IL)-6 is a pleiotropic inflammatory cytokine with both pro- and anti-inflammatory capacities, produced by different cells and tissues, such as leukocytes, adipocytes, and endothelium. ...Although IL-6 levels were detected in patients undergoing cardiac operations and reported sporadically, the perioperative kinetics of IL-6 in cardiac surgical patients was insufficiently elaborated. ...
Interleukin (IL)-6 is a pleiotropic inflammatory cytokine with both pro- and anti-inflammatory capacities, produced by differe
Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults.
Molano Franco D, et al. Cochrane Database Syst Rev 2019. PMID 31038735 Free PMC article.
OBJECTIVES: To determine the diagnostic accuracy of plasma interleukin-6 (IL-6) concentration for the diagnosis of bacterial sepsis in critically ill adults. ...AUTHORS' CONCLUSIONS: Our evidence assessment of plasma interleukin-6 concentrations for the diagnosis of sepsis in critically ill adults reveals several limitations. ...
OBJECTIVES: To determine the diagnostic accuracy of plasma interleukin-6 (IL-6) concentration for the diagnosis of bact …
Metabolites Associated With Circulating Interleukin-6 in Older Adults.
Lustgarten MS and Fielding RA. J Gerontol A Biol Sci Med Sci 2017. PMID 26975982 Free PMC article.
BACKGROUND: Circulating levels of the pro-inflammatory cytokine interleukin-6 (IL-6) levels are elevated in older adults, but mechanisms are unclear. ...METHODS: Serum IL-6 values were log-transformed to normalize its distribution. Multivariable-adjusted linear regression was used to examine the association between 324 serum metabolites with log IL-6. ...
BACKGROUND: Circulating levels of the pro-inflammatory cytokine interleukin-6 (IL-6) levels are elevated in older adult …
Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis.
Nilsonne G, et al. PLoS One 2016. PMID 27832117 Free PMC article.
The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by increasing in the blood at night. Earlier studies have reported diurnal variation of IL-6, but phase estimates are conflicting. We have therefore performed a meta-analysis on the diurnal variation of circulating IL-6. ...
The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by …
Whole blood gene expression and interleukin-6 levels.
Lin H, et al. Genomics 2014. PMID 25311648 Free PMC article.
BACKGROUND: Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortality. ...We identified 4139 genes that were significantly associated with interleukin-6 levels (FDR<0.05) after adjusting for age, sex and blood cell components. ...
BACKGROUND: Circulating interleukin-6 levels increase with advancing age and are a risk factor for various diseases and mortal …
Correlation study between interleukin-6 levels and coronary reflow.
Guo FM, et al. Eur Rev Med Pharmacol Sci 2017. PMID 28485795 Free article.
OBJECTIVE: To analyze the correlation between local interleukin-6 (IL-6) levels in different parts of blood vessel and the record of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) after myocardial ischemia-reperfusion (IR) model. ...The blood reflowed after 30 min. TIMI was recorded to evaluate the coronary blood flow and myocardial perfusion. IL-6 levels in venous sheath, coronary sinus, artery sinus, and proximal coronary artery were determined by ELISA. ...
OBJECTIVE: To analyze the correlation between local interleukin-6 (IL-6) levels in different parts of blood vess …
Interleukin 6 and cognitive dysfunction.
Trapero I and Cauli O. Metab Brain Dis 2014 - Review. PMID 24782046
The interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in interaction between immune and nervous system. Although IL-6 has neurotrophic properties and beneficial effects in the CNS, its overexpression is generally detrimental, adding to the pathophysiology associated with CNS disorders. ...Further research is needed to correlate specific deficits in IL-6 and its receptors in pathologies characterized by cognitive dysfunction and to understand how systemic IL-6 affects high cerebral function in order to open new directions in pharmacological treatments that modulate IL-6 signalling....
The interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in interaction between immune and nervous syst …
Interleukin 6 production during cardiac surgery correlates with increasing age.
Howell KW, et al. J Surg Res 2016. PMID 26850187
Proinflammatory cytokines such as interleukin 6 (IL-6) may contribute to morbidity and mortality after cardiopulmonary bypass (CPB). ...We hypothesized that patients aged >70 y produce more IL-6 during CPB. METHODS: Twenty-three patients (ages 23-80) undergoing cardiac surgery had blood sampled from the ascending aorta and coronary sinus on initial cannulation for bypass, at 30 min of aortic cross-clamp time, on release of the aortic cross-clamp, and at 20 min after reperfusion. ...
Proinflammatory cytokines such as interleukin 6 (IL-6) may contribute to morbidity and mortality after cardiopulmonary …
Interleukin-6: possible biological roles during exercise.
Reihmane D and Dela F. Eur J Sport Sci 2014 - Review. PMID 24655147
Interleukin-6 (IL-6) is a multifunctional cytokine that exerts its modulatory effects on cells that express membrane bound IL-6 receptors; however, IL-6 in a complex with soluble IL-6R can bind to any cell that express glycoprotein 130 (gp130). Thus, all cell types may respond to the pro- as well as anti-inflammatory properties of IL-6. Since the first report of acute exercise-induced increase in plasma IL-6 in the early 1990s, scientists have tried to elucidate the factors that influence the magnitude of change of plasma IL-6, as well as the possible biological roles of this cytokine. ...
Interleukin-6 (IL-6) is a multifunctional cytokine that exerts its modulatory effects on cells that express membrane bo
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