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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 11
1991 62
1992 99
1993 187
1994 219
1995 272
1996 344
1997 412
1998 456
1999 449
2000 501
2001 556
2002 606
2003 616
2004 647
2005 695
2006 742
2007 803
2008 787
2009 856
2010 873
2011 914
2012 1005
2013 922
2014 931
2015 887
2016 755
2017 739
2018 596
2019 248
2020 8
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15,497 results
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Page 1
Interleukin-8 in cancer pathogenesis, treatment and follow-up.
Alfaro C, et al. Cancer Treat Rev 2017 - Review. PMID 28866366
Interleukin-8 (CXCL8) was originally described asa chemokine whose main function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on CXCR1/2. ...Thus, IL-8 serum concentrations have been shown to be useful asa pharmacodynamic biomarker to early detect response to immunotherapy. ...
Interleukin-8 (CXCL8) was originally described asa chemokine whose main function is the attraction of a polymorphonuclear infl
The interleukin-8 pathway in cancer.
Waugh DJ and Wilson C. Clin Cancer Res 2008 - Review. PMID 18980965 Free article.
Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation. ...Increased expression of IL-8 and/or its receptors has been characterized in cancer cells, endothelial cells, infiltrating neutrophils, and tumor-associated macrophages, suggesting that IL-8 may function as a significant regulatory factor within the tumor microenvironment. ...
Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degr
Increased circulating interleukin-8 levels in systemic lupus erythematosus patients: a meta-analysis.
Mao YM, et al. Biomark Med 2018. PMID 30511585
AIM: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors. ...Subgroup analyses indicated SLE patients with age <40 years, Asia group and disease duration <10 years had higher IL-8 levels. ...
AIM: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus ery …
The Intrinsic Pepsin Resistance of Interleukin-8 Can Be Explained from a Combined Bioinformatical and Experimental Approach.
Anders G, et al. IEEE/ACM Trans Comput Biol Bioinform 2018. PMID 28113517
Interleukin-8 (IL-8, CXCL8) is a neutrophil chemotactic factor belonging to the family of chemokines. IL-8 was shown to resist pepsin cleavage displaying its high resistance to this protease. ...Such similarity could play a key role in understanding IL-8 resistance to the protease pepsin. To support this hypothesis, we applied pepsin assays confirming that intact IL-8 is not degraded by pepsin in comparison to IL-8 in a denaturated state. ...
Interleukin-8 (IL-8, CXCL8) is a neutrophil chemotactic factor belonging to the family of chemokines. IL-8 was s
Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis.
Zhou M, et al. PLoS One 2015. PMID 25996378 Free PMC article.
Previous studies showed that interleukin 8 (IL-8) may effectively and rapidly diagnose NS. OBJECTIVE: We conducted the systematic review and meta-analysis to investigate the diagnostic value of the IL-8 in NS. ...CONCLUSION: Meta-analysis showed IL-8 had a moderate accuracy (AUC=0.8908) for the diagnosis of NS. IL-8 is a helpful biomarker for early diagnosis of NS. ...
Previous studies showed that interleukin 8 (IL-8) may effectively and rapidly diagnose NS. OBJECTIVE: We conducted the …
Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis.
Finoti LS, et al. Medicine (Baltimore) 2017 - Review. PMID 28562542 Free PMC article.
BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). ...Meta-analysis of studies that measured IL-8 (pg/uL) in GCF found lower levels in CP patients. There are conflicting evidences regarding IL-8 levels in saliva....
BACKGROUND: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with …
Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue.
Dafar A, et al. Oral Dis 2017. PMID 28178402
OBJECTIVES: The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with geographic tongue (GT), as compared to control subjects. ...Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension. ...
OBJECTIVES: The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth facto …
Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model.
Krock E, et al. EBioMedicine 2019. PMID 31047862 Free PMC article.
Interleukin-8 (IL-8) expression was confirmed by ELISA in CSF and in intervertebral discs. The SPARC-null mouse model of progressive, age-dependent DD and chronic LBP was used for pre-clinical validation. Male SPARC-null and control mice received systemic Reparixin, a CXCR1/2 (receptors for IL-8 and murine analogues) inhibitor, for 8 weeks. ...
Interleukin-8 (IL-8) expression was confirmed by ELISA in CSF and in intervertebral discs. The SPARC-null mouse model o
Reciprocal interaction between macrophage migration inhibitory factor and interleukin-8 in gout.
Kim KW, et al. Clin Exp Rheumatol 2019. PMID 30148447
This study determined monosodium urate crystal-induced MIF production and its interaction with interleukin (IL)-8 in gout. METHODS: Peripheral blood (PB), synovial fluid (SF), and clinical data were obtained from 98 patients with gout. ...IL-8 increased MIF production in monocytes while MIF increased interleukin-8 production in neutrophils. CONCLUSIONS: MIF and IL-8 are highly produced in acute gout. ...
This study determined monosodium urate crystal-induced MIF production and its interaction with interleukin (IL)-8 in gout. MET …
Interleukin 8 and cardiovascular disease.
Apostolakis S, et al. Cardiovasc Res 2009 - Review. PMID 19617600
Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking and activation has advanced rapidly, especially in the field of cardiovascular disease. ...In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed....
Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking and acti
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