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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1980 10
1981 7
1982 29
1983 42
1984 81
1985 120
1986 118
1987 128
1988 104
1989 99
1990 73
1991 84
1992 105
1993 125
1994 152
1995 141
1996 158
1997 192
1998 225
1999 251
2000 276
2001 278
2002 220
2003 225
2004 291
2005 312
2006 370
2007 410
2008 533
2009 640
2010 712
2011 674
2012 706
2013 630
2014 749
2015 822
2016 627
2017 526
2018 596
2019 235
2020 3
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10,982 results
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Page 1
Alternative activation of macrophages
Gordon S. Nat Rev Immunol 2003 - Review. PMID 12511873
The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained credence in the past decade, to account for a distinctive macrophage phenotype that is consistent with a different role in humoral immunity and repair. ...
The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained …
IL-6 in inflammation, immunity, and disease
Tanaka T, et al. Cold Spring Harb Perspect Biol 2014 - Review. PMID 25190079 Free PMC article.
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. ...
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense th
Activation and regulation of the inflammasomes
Latz E, et al. Nat Rev Immunol 2013 - Review. PMID 23702978 Free PMC article.
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. ...
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inf …
IL-12 family cytokines: immunological playmakers
Vignali DA and Kuchroo VK. Nat Immunol 2012 - Review. PMID 22814351 Free PMC article.
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. ...
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. ...
The interleukin-1 family: back to the future.
Garlanda C, et al. Immunity 2013 - Review. PMID 24332029 Free PMC article.
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). ...
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist a
Impact of IL-12 in Cancer
Lu X. Curr Cancer Drug Targets 2017 - Review. PMID 28460617
BACKGROUND: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably. ...
BACKGROUND: Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, …
Interleukin-34, a comprehensive review.
Baghdadi M, et al. J Leukoc Biol 2018 - Review. PMID 30066957
One decade after its discovery, IL-34 has been introduced as a newcomer to the big family of interleukins with specific physiological functions, critical pathological roles, and promising clinical applications in disease diagnosis and treatment. ...
One decade after its discovery, IL-34 has been introduced as a newcomer to the big family of interleukins with specific physiological …
Interleukin-2: Biology, Design and Application.
Arenas-Ramirez N, et al. Trends Immunol 2015 - Review. PMID 26572555 Free article.
Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte responses. ...
Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimiz
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