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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 2
1978 12
1979 6
1980 19
1981 63
1982 173
1983 186
1984 333
1985 481
1986 619
1987 787
1988 964
1989 1175
1990 1372
1991 1637
1992 1831
1993 2071
1994 2321
1995 2605
1996 2851
1997 3105
1998 3224
1999 3430
2000 3778
2001 4064
2002 4139
2003 4440
2004 4589
2005 4864
2006 5075
2007 5645
2008 6127
2009 6676
2010 7025
2011 7637
2012 8180
2013 8332
2014 8315
2015 8215
2016 7852
2017 7721
2018 6943
2019 2906
2020 44
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137,838 results
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Page 1
NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
Grebe A, et al. Circ Res 2018 - Review. PMID 29880500
This concept was recently proven by CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study), which demonstrated the therapeutic potential of the monoclonal IL (interleukin)-1β-neutralizing antibody canakinumab. ...
This concept was recently proven by CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study), which demonstrated the therapeutic pot …
Inflammasome activation and assembly at a glance
Malik A and Kanneganti TD. J Cell Sci 2017 - Review. PMID 29196474 Free PMC article.
The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage, which further induces maturation of interleukins 1β and 18 (IL-1β and IL-18) through proteolytic cleavage of pro-IL-1β and pro-IL-18. ...
The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage, which further induces maturation of i
Dupilumab: A New Paradigm for the Treatment of Allergic Diseases
Sastre J and Dávila I. J Investig Allergol Clin Immunol 2018 - Review. PMID 29939132 Free article.
A leading example is dupilumab, a monoclonal antibody targeting the α chain of the interleukin (IL)-4 receptor. Dupilumab inhibits the biological effects of the cytokines IL-4 and IL-13, which are key drivers in the TH2 response. ...
A leading example is dupilumab, a monoclonal antibody targeting the α chain of the interleukin (IL)-4 receptor. Dupilumab inhibits th …
Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis.
Furue K, et al. Acta Derm Venereol 2018 - Review. PMID 28967976 Free article.
/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. ...
/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor …
The role of interleukins in vitiligo: a systematic review.
Gomes IA, et al. J Eur Acad Dermatol Venereol 2018. PMID 29704266
There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role of interleukins in vitiligo, focusing on interleukins. ...These findings illustrate the growing need for new therapies targeting vitiligo and further research into the role of interleukins as an area of particular interest....
There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present …
Structural mechanisms of inflammasome assembly
Lu A and Wu H. FEBS J 2015 - Review. PMID 25354325 Free PMC article.
Upon stimulation by microbial and damage-associated signals, inflammasomes assemble to elicit the first line of host defense via the proteolytic maturation of cytokines interleukin-1β and interleukin-18, and by induction of pyroptotic cell death. ...
Upon stimulation by microbial and damage-associated signals, inflammasomes assemble to elicit the first line of host defense via the proteol …
137,838 results
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