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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 4
1967 19
1968 38
1969 85
1970 61
1971 77
1972 85
1973 80
1974 82
1975 71
1976 89
1977 91
1978 86
1979 81
1980 69
1981 95
1982 95
1983 103
1984 109
1985 110
1986 116
1987 100
1988 117
1989 93
1990 106
1991 124
1992 138
1993 182
1994 199
1995 181
1996 208
1997 245
1998 242
1999 255
2000 327
2001 353
2002 425
2003 414
2004 380
2005 407
2006 436
2007 531
2008 483
2009 509
2010 547
2011 555
2012 532
2013 542
2014 560
2015 538
2016 524
2017 489
2018 531
2019 182
2020 0
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12,161 results
Results by year
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Page 1
Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.
Hu H, et al. Science 2014 - Review. PMID 25082707
The success story of fast-spiking, parvalbumin-positive (PV(+)) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy. ...Furthermore, the results may form the basis for PV(+) interneurons as therapeutic targets for brain disease in the future. However, much needs to be learned about the basic function of these interneurons before clinical neuroscientists will be able to use PV(+) interneurons for therapeutic purposes....
The success story of fast-spiking, parvalbumin-positive (PV(+)) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian c …
Interneuron dysfunction in psychiatric disorders.
Marín O. Nat Rev Neurosci 2012 - Review. PMID 22251963
Recent studies in animal models demonstrate that the molecular basis of such disruption is linked to specific defects in the development and function of interneurons - the cells that are responsible for establishing inhibitory circuits in the brain. ...
Recent studies in animal models demonstrate that the molecular basis of such disruption is linked to specific defects in the development and …
Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits.
Yavorska I and Wehr M. Front Neural Circuits 2016 - Review. PMID 27746722 Free PMC article.
Here, we review the function of somatostatin-expressing (SOM) inhibitory interneurons, focusing largely on sensory cortex. SOM neurons also comprise a number of subpopulations that can be distinguished by their morphology, input and output connectivity, laminar location, firing properties, and expression of molecular markers. ...Thus despite their heterogeneity and variability across cortical areas, current evidence shows that SOM neurons perform unique neural computations, forming not only distinct molecular but also functional subclasses of cortical inhibitory interneurons....
Here, we review the function of somatostatin-expressing (SOM) inhibitory interneurons, focusing largely on sensory cortex. SOM neuron …
Cervical excitatory neurons sustain breathing after spinal cord injury
Satkunendrarajah K, et al. Nature 2018. PMID 30305735
Although these interneurons are not necessary for breathing under normal conditions, their stimulation in non-injured animals enhances inspiratory amplitude. Immediately after spinal cord injury, pharmacogenetic stimulation of cervical excitatory interneurons restores respiratory motor function. ...
Although these interneurons are not necessary for breathing under normal conditions, their stimulation in non-injured animals enhance …
Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control.
Hayashi M, et al. Neuron 2018. PMID 29398364 Free article.
Types I and II V2a interneurons are arrayed in counter-gradients, and this network activates different patterns of motor output at cervical and lumbar levels. ...Our findings uncover a molecular and anatomical organization of V2a interneurons reminiscent of the orderly way motor neurons are divided into columns and pools....
Types I and II V2a interneurons are arrayed in counter-gradients, and this network activates different patterns of motor output at ce …
Taking a Big Step towards Understanding Locomotion
Wyart C. Trends Neurosci 2018 - Review. PMID 30471663
In their seminal 1987 publication, Buchanan and Grillner provided for the first time evidence for excitatory spinal neurons receiving inputs from descending commands and sensory afferents, and synapsing onto motoneurons and commissural inhibitory interneurons. These critical findings established the circuit model for central pattern generators incorporating excitatory interneurons' role in the rhythm-production mechanism....
In their seminal 1987 publication, Buchanan and Grillner provided for the first time evidence for excitatory spinal neurons receiving inputs …
Central Mechanisms of Itch
Carstens E and Akiyama T. Curr Probl Dermatol 2016 - Review. PMID 27578065 Free PMC article.
Itch is relieved by scratching, which activates spinal interneurons to inhibit itch-transmitting neurons. Spinal itch transmission is also thought to be modulated by descending pathways. ...
Itch is relieved by scratching, which activates spinal interneurons to inhibit itch-transmitting neurons. Spinal itch transmission is …
Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning.
Lee K, et al. Neuron 2017. PMID 28334608 Free PMC article.
The prevailing view is that striatal parvalbumin (PV)-positive interneurons primarily function to downregulate medium spiny projection neuron (MSN) activity via monosynaptic inhibitory signaling. ...Together, this work provides a possible mechanism by which PV interneurons modulate striatal output and selectively enhance performance early in learning....
The prevailing view is that striatal parvalbumin (PV)-positive interneurons primarily function to downregulate medium spiny projectio …
Differential processing of thalamic information via distinct striatal interneuron circuits.
Assous M, et al. Nat Commun 2017. PMID 28604688 Free PMC article.
Optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in NGF interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons. In contrast, the predominant response of PLTS interneurons is a disynaptic inhibition dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs). ...
Optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in NGF interneurons and a …
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