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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 10
1947 5
1948 8
1949 6
1950 22
1951 24
1952 28
1953 35
1954 32
1955 39
1956 43
1957 39
1958 39
1959 45
1960 46
1961 72
1962 63
1963 92
1964 358
1965 506
1966 502
1967 698
1968 856
1969 979
1970 973
1971 1070
1972 1229
1973 1049
1974 1031
1975 979
1976 880
1977 957
1978 1003
1979 1000
1980 890
1981 918
1982 896
1983 931
1984 1110
1985 1028
1986 1016
1987 865
1988 713
1989 803
1990 775
1991 715
1992 721
1993 730
1994 778
1995 683
1996 671
1997 653
1998 655
1999 560
2000 648
2001 752
2002 723
2003 699
2004 714
2005 710
2006 807
2007 819
2008 778
2009 788
2010 794
2011 700
2012 852
2013 827
2014 740
2015 758
2016 653
2017 644
2018 622
2019 310
2020 9
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43,626 results
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Page 1
Physiology of Intestinal Absorption and Secretion.
Kiela PR and Ghishan FK. Best Pract Res Clin Gastroenterol 2016 - Review. PMID 27086882 Free PMC article.
Virtually all nutrients from the diet are absorbed into blood across the highly polarized epithelial cell layer forming the small and large intestinal mucosa. ...In this chapter, we summarize the current state of knowledge regarding the mechanism of intestinal absorption of key nutrients such as sodium, anions (chloride, sulfate, oxalate), carbohydrates, amino acids and peptides, lipids, lipid- and water-soluble vitamins, as well as the major minerals and micronutrients. ...
Virtually all nutrients from the diet are absorbed into blood across the highly polarized epithelial cell layer forming the small and large …
Pharmacokinetics
Fan J and de Lannoy IA. Biochem Pharmacol 2014 - Review. PMID 24055064
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. ...Compound absorption and permeability are discussed in the context of intestinal absorption and brain penetration. The volume of distribution and plasma protein and tissue binding are covered as is the clearance (systemic, hepatic, renal, biliary) of both small and large molecules. ...
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, com …
Intestinal absorption of S-nitrosothiols: Permeability and transport mechanisms.
Bonetti J, et al. Biochem Pharmacol 2018. PMID 29935960 Free article.
However, the absorption of S-nitrosothiols by the intestine, which is the first limiting barrier for their vascular bioavailability, is rarely evaluated. Using an in vitro model of intestinal barrier, based on human cells, the present work aimed at elucidating the mechanisms of intestinal transport (passive or active, paracellular or transcellular pathway) and at predicting the absorption site of three S-nitrosothiols: S-nitrosoglutathione (GSNO), S-nitroso-N-acetyl-l-cysteine (NACNO) and S-nitroso-N-acetyl-d-penicillamine (SNAP). ...
However, the absorption of S-nitrosothiols by the intestine, which is the first limiting barrier for their vascular bioavailability, …
Intestinal absorption characteristics of imperialine: in vitro and in situ assessments.
Lin Q, et al. Acta Pharmacol Sin 2015. PMID 26051111 Free PMC article.
In this study we investigated the absorption characteristics of imperialine in intestinal segments based on an evaluation of its physicochemical properties. ...CONCLUSION: The intestinal absorptive characteristics of imperialine are closely related to its physicochemical properties. The passive membrane diffusion dominates the intestinal absorption of imperialine....
In this study we investigated the absorption characteristics of imperialine in intestinal segments based on an evaluation of i …
Circadian regulators of intestinal lipid absorption.
Hussain MM and Pan X. J Lipid Res 2015 - Review. PMID 25057097 Free PMC article.
Studies have shown that various proteins involved in lipid absorption and lipoprotein biosynthesis show circadian expression. Further, intestinal epithelial cells express circadian clock genes and these genes might control circadian expression of different proteins involved in intestinal lipid absorption. ...
Studies have shown that various proteins involved in lipid absorption and lipoprotein biosynthesis show circadian expression. Further …
The complex task of measuring intestinal permeability in basic and clinical science.
Galipeau HJ and Verdu EF. Neurogastroenterol Motil 2016 - Review. PMID 27339216
Intestinal permeability is a key feature of intestinal barrier function. Altered intestinal permeability is described in many chronic diseases and may be a risk factor for disease development and a target for emerging therapeutics. Thus, reliable and sensitive methods to measure intestinal permeability in both the clinical and preclinical setting are needed. ...
Intestinal permeability is a key feature of intestinal barrier function. Altered intestinal permeability is described i
Integrative physiology of transcellular and paracellular intestinal absorption.
Karasov WH. J Exp Biol 2017 - Review. PMID 28724701 Free article.
Our broader, integrative understanding of intestinal absorption requires more than the reductionist dissection of all the components and their elaboration at molecular and genetic levels. This Commentary emphasizes the integration of discrete molecular players and processes (including paracellular absorption) that, in combination, determine the overall epithelial absorption of key nutrients (e.g. sugars, amino acids) and putative anti-nutrients (water-soluble toxins), and the integration of that absorption with other downstream processes related to metabolic demands. ...
Our broader, integrative understanding of intestinal absorption requires more than the reductionist dissection of all the comp …
Intestinal cholesterol absorption.
Dawson PA and Rudel LL. Curr Opin Lipidol 1999 - Review. PMID 10482134
The strong association between intestinal cholesterol absorption and total plasma cholesterol level has renewed interest in the absorptive process and stimulated the generation of new animal models. Increasingly, new studies suggest that cholesterol absorption is genetically controlled and supports a protein-mediated mechanism for cholesterol uptake into the intestinal mucosal cell. ...
The strong association between intestinal cholesterol absorption and total plasma cholesterol level has renewed interest in th …
Glutamine and intestinal barrier function.
Wang B, et al. Amino Acids 2015 - Review. PMID 24965526
The intestinal barrier integrity is essential for the absorption of nutrients and health in humans and animals. Dysfunction of the mucosal barrier is associated with increased gut permeability and development of multiple gastrointestinal diseases. ...In addition, glutamine has been reported to enhance intestinal and whole-body growth, to promote enterocyte proliferation and survival, and to regulate intestinal barrier function in injury, infection, weaning stress, and other catabolic conditions. ...
The intestinal barrier integrity is essential for the absorption of nutrients and health in humans and animals. Dysfunction of …
Preface
Dijkstra G and Rings E. Best Pract Res Clin Gastroenterol 2016. PMID 27086881
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