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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 3
1968 9
1969 18
1970 15
1971 15
1972 17
1973 13
1974 10
1975 22
1976 16
1977 26
1978 32
1979 26
1980 25
1981 22
1982 30
1983 52
1984 36
1985 32
1986 49
1987 83
1988 75
1989 54
1990 51
1991 86
1992 90
1993 94
1994 106
1995 133
1996 147
1997 98
1998 123
1999 126
2000 146
2001 136
2002 132
2003 117
2004 145
2005 169
2006 163
2007 149
2008 177
2009 189
2010 214
2011 188
2012 197
2013 232
2014 262
2015 240
2016 215
2017 174
2018 220
2019 95
2020 2
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4,927 results
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Page 1
The Intestinal Epithelium: Central Coordinator of Mucosal Immunity.
Allaire JM, et al. Trends Immunol 2018 - Review. PMID 29716793
It must tolerate the presence of the luminal microbiota and thus not respond to their products, but still protect the intestinal mucosa from potentially harmful dietary antigens and invading pathogens. The intestinal epithelium, composed of a single layer of cells, is crucial for preserving gut homeostasis and acts both as a physical barrier and as a coordinating hub for immune defense and crosstalk between bacteria and immune cells. ...
It must tolerate the presence of the luminal microbiota and thus not respond to their products, but still protect the intestinal m
The intestinal barrier: a fundamental role in health and disease.
Vancamelbeke M and Vermeire S. Expert Rev Gastroenterol Hepatol 2017 - Review. PMID 28650209 Free PMC article.
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens come in close contact with the host immune system. Intestinal barrier defects have been associated with a broad range of diseases and therefore denote a new therapeutic target. ...
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens come in close contac …
Role of the intestinal mucosa in acute gastrointestinal GVHD.
Peled JU, et al. Blood 2016 - Review. PMID 27856471 Free PMC article.
The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. ...In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD....
The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal m …
Mouse models of inflammatory bowel disease for investigating mucosal immunity in the intestine
Bamias G, et al. Curr Opin Gastroenterol 2017 - Review. PMID 28901966
This review presents recent developments regarding the role of animal models of intestinal inflammation as research tools in IBD. ...The combination of chemical and genetically engineered models have revealed protective or harmful roles for various components of the innate immune system in response to acute injury and repair mechanisms for the intestinal mucosa. ...
This review presents recent developments regarding the role of animal models of intestinal inflammation as research tools in IBD. ... …
To respond or not to respond - a personal perspective of intestinal tolerance.
Mowat AM. Nat Rev Immunol 2018 - Review. PMID 29491358
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena. ...One of the most important aspects of the intestinal immune system is how it discriminates carefully between harmless and harmful antigens, in particular, its ability to generate active tolerance to materials such as commensal bacteria and food proteins. ...
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists an …
Epithelial immunity: priming defensive responses in the intestinal mucosa.
Pardo-Camacho C, et al. Am J Physiol Gastrointest Liver Physiol 2018 - Review. PMID 29146676 Free article.
As the largest interface between the outside and internal milieu, the intestinal epithelium constitutes the first structural component facing potential luminal threats to homeostasis. ...Regulated defensive activity maintains intestinal homeostasis, whereas a breakdown in the control of epithelial immunity can increase the intestinal passage of luminal content and microbial invasion, leading to inflammation and tissue damage. ...
As the largest interface between the outside and internal milieu, the intestinal epithelium constitutes the first structural componen …
Human intraepithelial lymphocytes
Mayassi T and Jabri B. Mucosal Immunol 2018 - Review. PMID 29674648 Free PMC article.
The line between sensing of foreign antigens and autoreactivity is blurred for IEL in celiac disease, where recognition of stress ligands by induced activating NK receptors in conjunction with inflammatory signals such as IL-15 can result in low-affinity TCR/non-cognate antigen and NK receptor/stress ligand interactions triggering destruction of intestinal epithelial cells....
The line between sensing of foreign antigens and autoreactivity is blurred for IEL in celiac disease, where recognition of stress ligands by …
Recent progress in organoid culture to model intestinal epithelial barrier functions.
Nakamura T. Int Immunol 2019 - Review. PMID 30281080
The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. ...In this review article, I showcase recent work that has utilized intestinal organoids to study various aspects of intestinal epithelial barrier functions....
The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also a …
The mucosal immune system: master regulator of bidirectional gut-brain communications
Powell N, et al. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28096541
The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota-gut-brain axis). ...
The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, …
The protective roles of NLRP6 in intestinal epithelial cells.
Yin J, et al. Cell Prolif 2019 - Review. PMID 30515917
The intestinal mucosal barrier is not a static barrier, but rather, it strongly interacts with the gut microbiome and cells of the immune system. ...This review summarizes the activation of NLRP6 and its protective role in the intestinal epithelial cell....
The intestinal mucosal barrier is not a static barrier, but rather, it strongly interacts with the gut microbiome and cells of the im …
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