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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 3
1947 3
1951 18
1952 23
1953 14
1954 16
1955 19
1956 25
1957 24
1958 13
1959 18
1960 22
1961 31
1962 21
1963 3
1964 11
1965 122
1966 205
1967 293
1968 363
1969 450
1970 454
1971 550
1972 673
1973 657
1974 740
1975 716
1976 625
1977 605
1978 620
1979 644
1980 607
1981 559
1982 607
1983 726
1984 715
1985 780
1986 713
1987 811
1988 776
1989 845
1990 880
1991 869
1992 1006
1993 930
1994 1032
1995 1143
1996 1132
1997 1166
1998 1275
1999 1267
2000 1353
2001 1314
2002 1398
2003 1401
2004 1444
2005 1639
2006 1727
2007 1755
2008 1751
2009 1899
2010 2014
2011 2225
2012 2388
2013 2463
2014 2452
2015 2418
2016 2220
2017 2247
2018 2052
2019 957
2020 26
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58,712 results
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Page 1
The intestinal barrier: a fundamental role in health and disease.
Vancamelbeke M and Vermeire S. Expert Rev Gastroenterol Hepatol 2017 - Review. PMID 28650209 Free PMC article.
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens come in close contact with the host immune system. Intestinal barrier defects have been associated with a broad range of diseases and therefore denote a new therapeutic target. ...
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens come in close contac …
The intestinal epithelial barrier: a therapeutic target?
Odenwald MA and Turner JR. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 27848962 Free PMC article.
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying immune system and the remainder of the body, while supporting vectorial transport of nutrients, water and waste products. ...Here, we review and discuss mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases. ...
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as …
Determinants of hypoxia-inducible factor activity in the intestinal mucosa.
Fagundes RR and Taylor CT. J Appl Physiol (1985) 2017 - Review. PMID 28408694 Free article.
The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and its juxtaposition with the anoxic environment of the intestinal lumen. ...The hypoxia-inducible factor (HIF), a ubiquitously expressed regulator of cellular adaptation to hypoxia, is central to both the adaptive and the inflammatory responses of cells of the intestinal mucosa in IBD patients. ...
The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply …
Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium
Sharkey KA, et al. Nat Rev Gastroenterol Hepatol 2018 - Review. PMID 30069036
The defensive functions of the intestinal epithelium are remarkable considering that the gut lumen is home to trillions of resident bacteria, fungi and protozoa (collectively, the intestinal microbiota) that must be prevented from translocation across the epithelial barrier. ...Together, they maintain homeostasis by integrating luminal signals, including those derived from the microbiota, to regulate the physiology of the gastrointestinal tract in health and disease. ...
The defensive functions of the intestinal epithelium are remarkable considering that the gut lumen is home to trillions of resident b …
Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins
Lau WL, et al. Clin Sci (Lond) 2018 - Review. PMID 29523750
Due to intestinal wall inflammation and degradation of intercellular tight junctions, gut-derived uremic toxins translocate into the bloodstream and exert systemic effects. ...
Due to intestinal wall inflammation and degradation of intercellular tight junctions, gut-derived uremic toxins translocate into the …
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis.
Buscarinu MC, et al. Neurotherapeutics 2018 - Review. PMID 29119385 Free PMC article.
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (CD), underpinned by a known unbalance between microbiota, IP and immune responses in the gut. ...In a recent work we found that an alteration of IP is a relatively frequent event in relapsing-remitting MS, with a possible genetic influence on the determinants of IP changes (as inferable from data on twins); IP changes included a deficit of the active mechanism of absorption from intestinal lumen. ...
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (C …
Intestinal lymphatic vasculature: structure, mechanisms and functions.
Bernier-Latmani J and Petrova TV. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28655884
In this Review, we provide in-depth information concerning the organization and structure of intestinal lymphatics, the current view of their developmental origins, as well as molecular mechanisms of intestinal lymphatic patterning and maintenance. We will also discuss physiological aspects of intestinal lymph flow regulation and the known and emerging roles of intestinal lymphatic vessels in human diseases, such as IBD, infection and cancer....
In this Review, we provide in-depth information concerning the organization and structure of intestinal lymphatics, the current view …
Autophagy: roles in intestinal mucosal homeostasis and inflammation.
Haq S, et al. J Biomed Sci 2019 - Review. PMID 30764829 Free PMC article.
The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and the local immune system maintains homeostasis and promotes a healthy gut. ...The aim of the current review is to provide an update on the role of autophagy in intestinal mucosal physiology and in the control of inappropriate inflammation....
The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In …
Recent progress in organoid culture to model intestinal epithelial barrier functions.
Nakamura T. Int Immunol 2019 - Review. PMID 30281080
The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. ...In this review article, I showcase recent work that has utilized intestinal organoids to study various aspects of intestinal epithelial barrier functions....
The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also a …
Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis.
Moor AE, et al. Cell 2018. PMID 30270040 Free article.
The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. ...
The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tas …
58,712 results
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