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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1965 2
1966 5
1967 8
1968 6
1969 15
1970 15
1971 14
1972 18
1973 19
1974 26
1975 17
1976 13
1977 12
1978 29
1979 16
1980 9
1981 15
1982 15
1983 13
1984 14
1985 13
1986 15
1987 29
1988 27
1989 25
1990 25
1991 32
1992 28
1993 25
1994 25
1995 30
1996 39
1997 52
1998 63
1999 46
2000 47
2001 61
2002 63
2003 50
2004 50
2005 53
2006 81
2007 71
2008 64
2009 72
2010 56
2011 80
2012 75
2013 85
2014 64
2015 62
2016 76
2017 79
2018 55
2019 40
2020 2
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1,929 results
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Page 1
The intestinal epithelial barrier: a therapeutic target?
Odenwald MA and Turner JR. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 27848962 Free PMC article.
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying immune system and the remainder of the body, while supporting vectorial transport of nutrients, water and waste products. ...Here, we review and discuss mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases. ...
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as …
Determinants of hypoxia-inducible factor activity in the intestinal mucosa.
Fagundes RR and Taylor CT. J Appl Physiol (1985) 2017 - Review. PMID 28408694 Free article.
The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and its juxtaposition with the anoxic environment of the intestinal lumen. ...The hypoxia-inducible factor (HIF), a ubiquitously expressed regulator of cellular adaptation to hypoxia, is central to both the adaptive and the inflammatory responses of cells of the intestinal mucosa in IBD patients. ...
The intestinal mucosa is exposed to fluctuations in oxygen levels due to constantly changing rates of oxygen demand and supply and it …
Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins
Lau WL, et al. Clin Sci (Lond) 2018 - Review. PMID 29523750
Due to intestinal wall inflammation and degradation of intercellular tight junctions, gut-derived uremic toxins translocate into the bloodstream and exert systemic effects. ...
Due to intestinal wall inflammation and degradation of intercellular tight junctions, gut-derived uremic toxins translocate into the …
Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium
Sharkey KA, et al. Nat Rev Gastroenterol Hepatol 2018 - Review. PMID 30069036
The defensive functions of the intestinal epithelium are remarkable considering that the gut lumen is home to trillions of resident bacteria, fungi and protozoa (collectively, the intestinal microbiota) that must be prevented from translocation across the epithelial barrier. Imbalances in the relationship between the intestinal microbiota and the host lead to the manifestation of diseases that range from disorders of motility and sensation (IBS) and intestinal inflammation (IBD) to behavioural and metabolic disorders, including autism and obesity. ...
The defensive functions of the intestinal epithelium are remarkable considering that the gut lumen is home to trillions of resident b …
Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease.
Roulis M and Flavell RA. Differentiation 2016 - Review. PMID 27165847
In this Review we summarize our current understanding of the biology of mesenchymal cells of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics covered include 1) the embryonic origin of mesenchymal cells of the intestinal lamina propria and their heterogeneity in adults, 2) the role of the mesenchyme in intestinal development, 3) the physiological function of fibroblasts and myofibroblasts in adults as part of the intestinal stem cell niche and the mucosal immune system and 4) the involvement of fibroblasts and myofibroblasts in epithelial homeostasis upon injury and in the pathogenesis of diseases such as Inflammatory Bowel Diseases, fibrosis and cancer. ...
In this Review we summarize our current understanding of the biology of mesenchymal cells of the intestinal lamina propria focusing m …
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis.
Buscarinu MC, et al. Neurotherapeutics 2018 - Review. PMID 29119385 Free PMC article.
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (CD), underpinned by a known unbalance between microbiota, IP and immune responses in the gut. ...In a recent work we found that an alteration of IP is a relatively frequent event in relapsing-remitting MS, with a possible genetic influence on the determinants of IP changes (as inferable from data on twins); IP changes included a deficit of the active mechanism of absorption from intestinal lumen. ...
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (C …
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair.
Luissint AC, et al. Gastroenterology 2016 - Review. PMID 27436072 Free PMC article.
We review our current understanding of complex interactions between the intestinal epithelium and immune cells, with a focus on pathologic mucosal inflammation and mechanisms of epithelial repair. ...Increased knowledge of communication networks between the epithelium and immune system will lead to tissue-specific strategies for treating pathologic intestinal inflammation....
We review our current understanding of complex interactions between the intestinal epithelium and immune cells, with a focus on patho …
Spectrum of Drug-induced Chronic Diarrhea
Philip NA, et al. J Clin Gastroenterol 2017 - Review. PMID 28027072
The disease may either be associated with intestinal mucosal changes, mimicking diseases such as celiac disease, or purely functional, with no histopathologic change. ...
The disease may either be associated with intestinal mucosal changes, mimicking diseases such as celiac disease, or purely functional …
The intestinal barrier function and its involvement in digestive disease.
Salvo Romero E, et al. Rev Esp Enferm Dig 2015 - Review. PMID 26541659 Free article.
To this end, the intestine developed the "intestinal barrier function", a defensive system involving various elements, both intra- and extracellular, that work in a coordinated way to impede the passage of antigens, toxins, and microbial byproducts, and simultaneously preserves the correct development of the epithelial barrier, the immune system, and the acquisition of tolerance against dietary antigens and the intestinal microbiota. ...This review details de various elements of the intestinal barrier function, and the key molecular and cellular changes described for gastrointestinal diseases associated with dysfunction in this defensive mechanism....
To this end, the intestine developed the "intestinal barrier function", a defensive system involving various elements, both intra- an …
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