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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 4
1948 6
1949 2
1951 3
1952 4
1953 7
1954 2
1955 5
1956 5
1957 4
1958 3
1960 2
1961 4
1962 14
1963 9
1964 7
1965 3
1967 3
1968 30
1969 94
1970 185
1971 238
1972 312
1973 348
1974 513
1975 668
1976 780
1977 802
1978 856
1979 867
1980 1157
1981 1211
1982 1382
1983 1409
1984 1616
1985 1698
1986 1759
1987 1796
1988 1984
1989 2249
1990 2557
1991 3020
1992 3545
1993 4338
1994 5906
1995 7236
1996 8503
1997 10017
1998 12067
1999 14240
2000 16566
2001 18648
2002 19900
2003 21923
2004 23821
2005 25912
2006 28613
2007 29586
2008 30954
2009 32717
2010 34480
2011 36453
2012 38800
2013 40610
2014 40608
2015 40934
2016 39007
2017 37909
2018 36578
2019 17001
2020 348
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636,709 results
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Page 1
p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.
Katsuragi Y, et al. FEBS J 2015 - Review. PMID 26432171 Free article.
p62/SQSTM1 is a stress-inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. ...
p62/SQSTM1 is a stress-inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple dom …
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.
Ray PD, et al. Cell Signal 2012 - Review. PMID 22286106 Free PMC article.
Cellular ROS sensing and metabolism are tightly regulated by a variety of proteins involved in the redox (reduction/oxidation) mechanism. This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases, PI3 kinase, PTEN, and protein tyrosine phosphatases), ROS homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, Ref-1, and Nrf-2), mitochondrial oxidative stress, apoptosis, and aging (p66Shc), iron homeostasis through iron-sulfur cluster proteins (IRE-IRP), and ATM-regulated DNA damage response....
Cellular ROS sensing and metabolism are tightly regulated by a variety of proteins involved in the redox (reduction/oxidation) mechan …
DEPTOR at the Nexus of Cancer, Metabolism, and Immunity
Caron A, et al. Physiol Rev 2018 - Review. PMID 29897294 Free PMC article.
Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches aiming at modulating mTOR activity are envisioned as an attractive strategy to improve human health. DEPTOR interaction with mTOR represses its kinase activity and rewires the mTOR signaling pathway. Over the last years, several studies have revealed key roles for DEPTOR in numerous biological and pathological processes. ...
Defects in mTOR signaling have been associated with the development of many diseases, including cancer and diabetes, and approaches a …
TIPE Family of Proteins and Its Implications in Different Chronic Diseases.
Bordoloi D, et al. Int J Mol Sci 2018 - Review. PMID 30274259 Free PMC article.
The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. ...Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases....
The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly …
SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy
Cheng X, et al. Curr Top Med Chem 2018 - Review. PMID 29788888 Free PMC article.
Sterol regulatory element-binding proteins (SREBPs), which are central players in lipid metabolism, are endoplasmic reticulum (ER)-bound transcription factors that control the expression of genes important for lipid synthesis and uptake. ...
Sterol regulatory element-binding proteins (SREBPs), which are central players in lipid metabolism, are endoplasmic reticulum (ER)-bo …
A division of labor in mTORC1 signaling and autophagy.
Martens S. Sci Signal 2018 - Review. PMID 30514809
In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor....
In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In th …
GEFs and GAPs: critical elements in the control of small G proteins.
Bos JL, et al. Cell 2007 - Review. PMID 17540168 Free article.
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular functions. In general, GEFs turn on signaling by catalyzing the exchange from G-protein-bound GDP to GTP, whereas GAPs terminate signaling by inducing GTP hydrolysis. ...
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-bi …
Functional and pathological relevance of HERC family proteins: a decade later.
Sánchez-Tena S, et al. Cell Mol Life Sci 2016 - Review. PMID 26801221
The HERC gene family encodes proteins with two characteristic domains in their sequence: the HECT domain and the RCC1-like domain (RLD). ...Accumulating evidence shows the HERC family proteins to be key components of a wide range of cellular functions, including neurodevelopment, DNA damage repair, cell growth and immune response. ...
The HERC gene family encodes proteins with two characteristic domains in their sequence: the HECT domain and the RCC1-like domain (RL …
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