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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 3
1968 17
1969 60
1970 131
1971 165
1972 229
1973 283
1974 442
1975 579
1976 691
1977 722
1978 744
1979 736
1980 885
1981 833
1982 848
1983 816
1984 945
1985 913
1986 918
1987 847
1988 888
1989 907
1990 1022
1991 1117
1992 1222
1993 1593
1994 2204
1995 2618
1996 3173
1997 4112
1998 5097
1999 6464
2000 8334
2001 9674
2002 10253
2003 11399
2004 12660
2005 15130
2006 18809
2007 20270
2008 21951
2009 24000
2010 25696
2011 27585
2012 29586
2013 30885
2014 29953
2015 29856
2016 29018
2017 28077
2018 26829
2019 11722
2020 177
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414,680 results
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Page 1
YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer.
Noguchi S, et al. Int J Mol Sci 2018 - Review. PMID 30463366 Free PMC article.
In fibroblasts, ECM stiffness mechanoactivates YAP/TAZ, which promote the production of profibrotic mediators and ECM proteins. ...Importantly, the crosstalk with transforming growth factor (TGF)-β signaling and Wnt signaling is essential for the profibrotic and tumorigenic roles of YAP/TAZ. ...
In fibroblasts, ECM stiffness mechanoactivates YAP/TAZ, which promote the production of profibrotic mediators and ECM proteins. ...Im …
Recent advances in inflammasome biology
Place DE and Kanneganti TD. Curr Opin Immunol 2018 - Review. PMID 29128729 Free PMC article.
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an inflammatory form of cell death termed pyroptosis. ...Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death....
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, an …
BCL-2 family proteins: changing partners in the dance towards death.
Kale J, et al. Cell Death Differ 2018 - Review. PMID 29149100 Free PMC article.
Further, we explain the importance of using full-length BCL-2 family proteins (versus truncated versions or peptides) to parse out the core mechanisms of MOMP regulation by the BCL-2 family. Finally, we discuss how post-translational modifications and differing intracellular localizations alter the mechanisms of apoptosis regulation by BCL-2 family proteins. ...
Further, we explain the importance of using full-length BCL-2 family proteins (versus truncated versions or peptides) to parse …
Molecular mechanisms of inflammasome signaling.
Mathur A, et al. J Leukoc Biol 2018 - Review. PMID 28855232
These include pore-forming gasdermin proteins, the never in mitosis A-related kinase 7 (NEK7), IFN-inducible proteins (IFIs), reactive oxygen species (ROS), autophagy, potassium efflux, mitochondrial perturbations, and microbial metabolites. Here, we provide a comprehensive overview of the molecular and signaling mechanisms that provide stringent regulation over the activation and effector functions of the inflammasome....
These include pore-forming gasdermin proteins, the never in mitosis A-related kinase 7 (NEK7), IFN-inducible proteins (IFIs), …
Small GTPases
Reiner DJ and Lundquist EA. WormBook 2018 - Review. PMID 27218782 Free PMC article.
Members of the protein superfamily of small guanosine triphosphatases, also known as small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect of cell biology. ...We do not discuss the multitude of other proteins with catalytic guanosine triphosphatase domains that fall outside the small GTPase/Ras superfamily....
Members of the protein superfamily of small guanosine triphosphatases, also known as small GTPases, small G-proteins, or the Ras supe …
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.
Yoon MS. Nutrients 2017 - Review. PMID 29077002 Free PMC article.
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). ...This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism....
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell gr …
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
Mendoza MC, et al. Trends Biochem Sci 2011 - Review. PMID 21531565 Free PMC article.
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms for controlling cell survival, differentiation, proliferation, metabolism, and motility in response to extracellular cues. ...Ras-ERK and PI3K-mTOR were originally modeled as linear signaling conduits activated by different stimuli, yet even early experiments hinted that they might intersect to regulate each other and co-regulate downstream functions. ...
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signa
So Many Roads: the Multifaceted Regulation of Autophagy Induction
Corona Velazquez AF and Jackson WT. Mol Cell Biol 2018 - Review. PMID 30126896 Free PMC article.
The ULK1/2 complex induces autophagy by phosphorylating downstream autophagy complexes, such as the BECN1 PIK3 signaling complex that leads to the creation of LC3(+) autophagosomes. ...We illustrate that autophagy induction and the components required vary by the nature of the induction signal and type of cell and do not always require canonical members of the autophagy signaling pathway. ...
The ULK1/2 complex induces autophagy by phosphorylating downstream autophagy complexes, such as the BECN1 PIK3 signaling complex that …
Compartmentalisation of RAC1 signalling
Payapilly A and Malliri A. Curr Opin Cell Biol 2018 - Review. PMID 29723737
RAC1 is regulated by a large number of proteins that can promote its recruitment, activation, deactivation, or stability. RAC1 and its regulators are subject to various post-translational modifications that further fine tune RAC1 localisation, levels and activity. ...
RAC1 is regulated by a large number of proteins that can promote its recruitment, activation, deactivation, or stability. RAC1 and it …
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