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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 1
2003 1
2005 3
2006 4
2007 3
2008 4
2009 8
2010 4
2011 5
2012 4
2013 4
2014 3
2015 3
2016 3
2017 3
2018 1
2019 1
2020 3
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Search Results

56 results
Results by year
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Page 1
Ultra-large library docking for discovering new chemotypes.
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ. Lyu J, et al. Among authors: Irwin JJ. Nature. 2019 Feb;566(7743):224-229. doi: 10.1038/s41586-019-0917-9. Epub 2019 Feb 6. Nature. 2019. PMID: 30728502 Free PMC article.
Discovery of new GPCR ligands to illuminate new biology.
Roth BL, Irwin JJ, Shoichet BK. Roth BL, et al. Among authors: Irwin JJ. Nat Chem Biol. 2017 Nov;13(11):1143-1151. doi: 10.1038/nchembio.2490. Epub 2017 Oct 18. Nat Chem Biol. 2017. PMID: 29045379 Free PMC article.
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.
Stein RM, Kang HJ, McCorvy JD, Glatfelter GC, Jones AJ, Che T, Slocum S, Huang XP, Savych O, Moroz YS, Stauch B, Johansson LC, Cherezov V, Kenakin T, Irwin JJ, Shoichet BK, Roth BL, Dubocovich ML. Stein RM, et al. Among authors: Irwin JJ. Nature. 2020 Mar;579(7800):609-614. doi: 10.1038/s41586-020-2027-0. Epub 2020 Feb 10. Nature. 2020. PMID: 32040955
Predicting new molecular targets for known drugs.
Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Keiser MJ, et al. Among authors: Irwin JJ. Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1. Nature. 2009. PMID: 19881490 Free PMC article.
Predicted Biological Activity of Purchasable Chemical Space.
Irwin JJ, Gaskins G, Sterling T, Mysinger MM, Keiser MJ. Irwin JJ, et al. J Chem Inf Model. 2018 Jan 22;58(1):148-164. doi: 10.1021/acs.jcim.7b00316. Epub 2017 Dec 29. J Chem Inf Model. 2018. PMID: 29193970 Free PMC article.
A Molecular Basis for Innovation in Drug Excipients.
Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. Irwin JJ, et al. Clin Pharmacol Ther. 2017 Mar;101(3):320-323. doi: 10.1002/cpt.458. Epub 2016 Sep 28. Clin Pharmacol Ther. 2017. PMID: 27557422 Review.
The chemical basis of pharmacology.
Keiser MJ, Irwin JJ, Shoichet BK. Keiser MJ, et al. Among authors: Irwin JJ. Biochemistry. 2010 Dec 7;49(48):10267-76. doi: 10.1021/bi101540g. Epub 2010 Nov 12. Biochemistry. 2010. PMID: 21058655 Free PMC article. Review.
Docking Screens for Novel Ligands Conferring New Biology.
Irwin JJ, Shoichet BK. Irwin JJ, et al. J Med Chem. 2016 May 12;59(9):4103-20. doi: 10.1021/acs.jmedchem.5b02008. Epub 2016 Mar 15. J Med Chem. 2016. PMID: 26913380 Free PMC article. Review.
How good is your screening library?
Irwin JJ. Irwin JJ. Curr Opin Chem Biol. 2006 Aug;10(4):352-6. doi: 10.1016/j.cbpa.2006.06.003. Epub 2006 Jun 21. Curr Opin Chem Biol. 2006. PMID: 16797220 Review.
Anemia in children.
Irwin JJ, Kirchner JT. Irwin JJ, et al. Am Fam Physician. 2001 Oct 15;64(8):1379-86. Am Fam Physician. 2001. PMID: 11681780 Free article. Review.
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