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1

Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice.

Hayano H, Kuroshima S, Sasaki M, Tamaki S, Inoue M, Ishisaki A, Sawase T. Hayano H, et al. Among authors: Ishisaki A. Bone. 2020 Jun;135:115308. doi: 10.1016/j.bone.2020.115308. Epub 2020 Mar 3. Bone. 2020. PMID: 32142911

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2

IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals.

Ohta M, Chosa N, Kyakumoto S, Yokota S, Okubo N, Nemoto A, Kamo M, Joh S, Satoh K, Ishisaki A. Ohta M, et al. Among authors: Ishisaki A. Int J Mol Med. 2018 Sep;42(3):1484-1494. doi: 10.3892/ijmm.2018.3714. Epub 2018 Jun 4. Int J Mol Med. 2018. PMID: 29901090 Free PMC article.

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3

Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin.

Chosa N, Ishisaki A. Chosa N, et al. Among authors: Ishisaki A. Jpn Dent Sci Rev. 2018 Feb;54(1):37-44. doi: 10.1016/j.jdsr.2017.10.001. Epub 2017 Nov 9. Jpn Dent Sci Rev. 2018. PMID: 29629000 Free PMC article. Review.

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4

Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint.

Ibi M, Horie S, Kyakumoto S, Chosa N, Yoshida M, Kamo M, Ohtsuka M, Ishisaki A. Ibi M, et al. Among authors: Ishisaki A. Biosci Rep. 2018 Mar 29;38(2):BSR20171217. doi: 10.1042/BSR20171217. Print 2018 Apr 27. Biosci Rep. 2018. PMID: 29535277 Free PMC article.

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5

Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells.

Nemoto A, Chosa N, Kyakumoto S, Yokota S, Kamo M, Noda M, Ishisaki A. Nemoto A, et al. Among authors: Ishisaki A. Mol Med Rep. 2018 Mar;17(3):3448-3454. doi: 10.3892/mmr.2017.8287. Epub 2017 Dec 18. Mol Med Rep. 2018. PMID: 29257332 Free PMC article.

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6

Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture.

Takizawa N, Okubo N, Kamo M, Chosa N, Mikami T, Suzuki K, Yokota S, Ibi M, Ohtsuka M, Taira M, Yaegashi T, Ishisaki A, Kyakumoto S. Takizawa N, et al. Among authors: Ishisaki A. Exp Cell Res. 2017 Sep 15;358(2):411-420. doi: 10.1016/j.yexcr.2017.07.014. Epub 2017 Jul 14. Exp Cell Res. 2017. PMID: 28712928 Free article.

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7

α2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function.

Kanno Y, Ishisaki A, Kuretake H, Maruyama C, Matsuda A, Matsuo O. Kanno Y, et al. Among authors: Ishisaki A. Int J Mol Med. 2017 Sep;40(3):854-858. doi: 10.3892/ijmm.2017.3055. Epub 2017 Jul 5. Int J Mol Med. 2017. PMID: 28677806

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8

uPA-derived peptide, Å6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss.

Kanno Y, Maruyama C, Matsuda A, Ishisaki A. Kanno Y, et al. Among authors: Ishisaki A. Immun Inflamm Dis. 2017 Sep;5(3):289-299. doi: 10.1002/iid3.169. Epub 2017 May 11. Immun Inflamm Dis. 2017. PMID: 28493442 Free PMC article.

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9

SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells.

Inoue M, Yamada J, Aomatsu-Kikuchi E, Satoh K, Kondo H, Ishisaki A, Chosa N. Inoue M, et al. Among authors: Ishisaki A. Mol Med Rep. 2017 Jun;15(6):4069-4076. doi: 10.3892/mmr.2017.6492. Epub 2017 Apr 20. Mol Med Rep. 2017. PMID: 28440453 Free PMC article.

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10

ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint.

Yokota S, Chosa N, Kyakumoto S, Kimura H, Ibi M, Kamo M, Satoh K, Ishisaki A. Yokota S, et al. Among authors: Ishisaki A. Int J Mol Med. 2017 Apr;39(4):799-808. doi: 10.3892/ijmm.2017.2896. Epub 2017 Feb 17. Int J Mol Med. 2017. PMID: 28259960 Free PMC article.

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