Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 7
1989 23
1990 45
1991 60
1992 92
1993 68
1994 71
1995 76
1996 72
1997 87
1998 70
1999 61
2000 77
2001 73
2002 56
2003 70
2004 52
2005 80
2006 64
2007 85
2008 89
2009 109
2010 114
2011 110
2012 112
2013 127
2014 126
2015 131
2016 117
2017 123
2018 112
2019 50
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

2,423 results
Results by year
Filters applied: . Clear all
Page 1
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.
Akter R, et al. J Diabetes Res 2016 - Review. PMID 26649319 Free PMC article.
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell dysfunction and death in the disease and to the failure of islet transplants. Recent work suggests a role for IAPP aggregation in cardiovascular complications of type-2 diabetes and hints at a possible role in type-1 diabetes. ...
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form i
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
Lam YPY, et al. Chem Commun (Camb) 2018. PMID 30474090
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). ...
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amy
Islet amyloid polypeptide: Another key molecule in Alzheimer's pathogenesis?
Zhang Y and Song W. Prog Neurobiol 2017 - Review. PMID 28274676
Aggregation of human islet amyloid polypeptide (hIAPP), the pathological hallmark of T2DM, has also been detected in brain tissue and is associated with cognitive decline and AD development. In addition, hIAPP and amyloid β protein (Aβ) share many biophysical and physiological properties as well as exert similar cytotoxic mechanisms. ...
Aggregation of human islet amyloid polypeptide (hIAPP), the pathological hallmark of T2DM, has also been detected in br …
The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells.
Guan H, et al. PLoS One 2015. PMID 26191799 Free PMC article.
Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP). ...These results suggest that pitrilysin regulates islet amyloid polypeptide in beta cells and suggest the presence of an intramitochondrial pool of islet amyloid polypeptide involved in beta-cell apoptosis....
Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amylo
Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition.
Zhang X, et al. Biochemistry 2017. PMID 28054763 Free PMC article.
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced toxicity. ...NaCl reduces the rate of membrane-catalyzed amyloid formation by anionic vesicles, but accelerates amyloid formation in solution. ...
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in type 2 diabetes. Pert
Islet Amyloid Polypeptide Promotes Amyloid-Beta Aggregation by Binding-Induced Helix-Unfolding of the Amyloidogenic Core.
Ge X, et al. ACS Chem Neurosci 2018. PMID 29378116 Free PMC article.
Amyloid aggregation of amyloid-beta (Aβ) and islet amyloid polypeptide (IAPP) is associated with Alzheimer's disease (AD) and type-2 diabetes (T2D), respectively. ...
Amyloid aggregation of amyloid-beta (Aβ) and islet amyloid polypeptide (IAPP) is associated with Alzheime
Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.
Wijesekara N, et al. FASEB J 2017. PMID 28808140
AD and T2D are characterized by deposition of cerebral amyloid-β (Aβ) and pancreatic human islet amyloid polypeptide (hIAPP), respectively. ...Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model....
AD and T2D are characterized by deposition of cerebral amyloid-β (Aβ) and pancreatic human islet amyloid polypeptide
β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor.
Mirecka EA, et al. Sci Rep 2016. PMID 27641459 Free PMC article.
In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of islet cell transplantation. Rational design of inhibitors of IAPP amyloid formation has therapeutic potential, but is hampered by the lack of structural information on inhibitor complexes of the conformationally flexible, aggregation-prone IAPP. ...
In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is asso …
Measurement of Pro-Islet Amyloid Polypeptide (1-48) in Diabetes and Islet Transplants.
Courtade JA, et al. J Clin Endocrinol Metab 2017. PMID 28368485
CONTEXT: Islet amyloid is a feature of β-cell failure in type 2 diabetes (T2D) and type 1 diabetes (T1D) recipients of islet transplants. Islet amyloid contains islet amyloid polypeptide (IAPP; amylin), a circulating peptide that is produced in β cells by processing of its precursor, proIAPP1-67, via an intermediate form, proIAPP1-48. ...
CONTEXT: Islet amyloid is a feature of β-cell failure in type 2 diabetes (T2D) and type 1 diabetes (T1D) recipients of isle
Sterol Structure Strongly Modulates Membrane-Islet Amyloid Polypeptide Interactions.
Zhang X, et al. Biochemistry 2018. PMID 29373018 Free PMC article.
Amyloid formation has been implicated in a wide range of human diseases, and the interaction of amyloidogenic proteins with membranes are believed to be important for many of them. In type-2 diabetes, human islet amyloid polypeptide (IAPP) forms amyloids, which contribute to β-cell death and dysfunction in the disease. ...
Amyloid formation has been implicated in a wide range of human diseases, and the interaction of amyloidogenic proteins with membranes
2,423 results
Jump to page
Feedback