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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1974 3
1975 21
1976 16
1977 18
1978 11
1979 12
1980 5
1981 23
1982 27
1983 47
1984 89
1985 94
1986 159
1987 227
1988 195
1989 204
1990 229
1991 281
1992 272
1993 325
1994 341
1995 335
1996 317
1997 293
1998 347
1999 257
2000 257
2001 251
2002 236
2003 246
2004 283
2005 294
2006 292
2007 276
2008 282
2009 274
2010 263
2011 283
2012 276
2013 299
2014 300
2015 288
2016 299
2017 296
2018 205
2019 121
2020 0
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9,010 results
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Page 1
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment.
Wang Z, et al. J Neuroinflammation 2018. PMID 29665808 Free PMC article.
Morris water maze test was carried out 1 week after the isoflurane anesthesia. Brain tissues were harvested 24 h after the isoflurane anesthesia. ...Downregulation of NLRP3 attenuated the activation of NLRP3 inflammasome by isoflurane. CONCLUSIONS: NLRP3 priming status in aged mouse brain may be involved in isoflurane-induced hippocampal inflammation and cognitive impairment....
Morris water maze test was carried out 1 week after the isoflurane anesthesia. Brain tissues were harvested 24 h after the isoflur
Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment.
Zuo CL, et al. CNS Neurosci Ther 2018. PMID 29345054 Free PMC article.
RESULTS: For cognitive test, WT mice with isoflurane exposure performed worse than the WT mice without isoflurane exposure. However, A1AR KO mice with isoflurane exposure performed better than WT mice with isoflurane exposure. WT mice exposed to isoflurane had increased levels of Aβ and phosphorylated tau (P-tau). Levels of Aβ and P-tau were decreased in A1AR KO mice, whereas no differences were noted between KO mice with and without isoflurane exposure. ...
RESULTS: For cognitive test, WT mice with isoflurane exposure performed worse than the WT mice without isoflurane exposure. Ho …
Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I.
Zimin PI, et al. Br J Anaesth 2018. PMID 29661379 Free PMC article.
The volatile anaesthetic isoflurane selectively decreases the frequency of spontaneous excitatory events in hippocampal slices from Ndufs4(KO) mice. ...RESULTS: Isoflurane specifically inhibits complex I dependent respiration at lower concentrations in mitochondria from Ndufs4(KO) than from wild-type mice. ...
The volatile anaesthetic isoflurane selectively decreases the frequency of spontaneous excitatory events in hippocampal slices from N …
Assessing the depth of isoflurane anaesthesia during cardiopulmonary bypass.
Ng KT, et al. Perfusion 2018. PMID 28985693
The aim of this study was to determine the relationships between oxygenator exhaust and blood concentrations of isoflurane and the BIS score during CPB when administering isoflurane into the sweep gas supply to the oxygenator. ...On CPB, the median BIS was 39 (range, 7-43) and the mean oxygenator exhaust isoflurane concentration was 1.24 ± 0.21%. No significant correlation was demonstrated between BIS with arterial isoflurane concentration (r=-0.19, p=0.47) or oxygenator exhaust isoflurane concentration (r=0.07, p=0.80). ...
The aim of this study was to determine the relationships between oxygenator exhaust and blood concentrations of isoflurane and the BI …
Isoflurane post-conditioning influences myocardial infarct healing in rats.
Agnic I, et al. Biotech Histochem 2018. PMID 29611725
We investigated whether isoflurane post-conditioning stimulates differentiation of progenitor cells to myofibroblasts and to verify our hypothesis that isoflurane post-conditioning improves maturation of a myocardial scar. ...From the last 5 min of ischemia until 10 min into reperfusion, the isoflurane group received 1.5% isoflurane, while the control group received only an air-oxygen mixture. ...
We investigated whether isoflurane post-conditioning stimulates differentiation of progenitor cells to myofibroblasts and to verify o …
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats.
Wang X, et al. Drug Des Devel Ther 2018. PMID 30613136 Free PMC article.
Recent studies have shown that dexmedetomidine can reduce isoflurane-induced neuronal injury, but the mechanism remains unclear. ...Furthermore, we examined if dexmedetomidine could decrease isoflurane-induced neurotoxicity. METHODS: Neonatal rats (postnatal day 7, n=144) were randomly divided into four groups of 36 animals each: control (saline injection without isoflurane); isoflurane (2% for 4 h); isoflurane + single dose of dexmedetomidine (75 µg/kg, 20 min before the start of 2% isoflurane for 4 h); and isoflurane + dual doses of dexmedetomidine (25 µg/kg, 20 min before and 2 h after start of isoflurane at 2% for 4 h). ...
Recent studies have shown that dexmedetomidine can reduce isoflurane-induced neuronal injury, but the mechanism remains unclear. ...F …
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.
Zhang SS, et al. Psychopharmacology (Berl) 2019. PMID 31197433
CONCLUSION: Our study indicates that isoflurane exerts a rapid antidepressant-like effect in CUMS depression animal model, and the activation of BDNF/TrkB signaling pathway plays an indispensable role in the biological and behavioral antidepressant effects of isoflurane. A single exposure to isoflurane could repair synaptic damage caused by chronic stimulation....
CONCLUSION: Our study indicates that isoflurane exerts a rapid antidepressant-like effect in CUMS depression animal model, and the ac …
Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice-Assessing the degree of distress.
Hohlbaum K, et al. PLoS One 2017. PMID 28617851 Free PMC article.
However, repeated isoflurane anesthesia caused only short-term mild distress and impairment of well-being, mainly in the immediate postanesthetic period. ...However, within the mild severity category, repeated isoflurane anesthesia ranks higher than single isoflurane anesthesia. Additionally, our results imply that male and female mice can differently perceive the severity of a procedure....
However, repeated isoflurane anesthesia caused only short-term mild distress and impairment of well-being, mainly in the immediate po …
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
Song J, et al. Exp Neurol 2018. PMID 29660304
We constructed POCD model by submitting the mice to 5-h 1.3% isoflurane anesthesia from Zeitgeber Time (ZT) 14 to ZT19. Under novel object recognition assay (NOR) and Morris water maze (MWM) test, We found 5-h isoflurane anesthesia impaired the cognition of young mice for early 3 days after anesthesia but damaged the aged for at least 1 week. ...Melatonin could prevent isoflurane-induced cognitive impairments by circadian rhythm resynchronization....
We constructed POCD model by submitting the mice to 5-h 1.3% isoflurane anesthesia from Zeitgeber Time (ZT) 14 to ZT19. Under novel o …
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents.
Antila H, et al. Sci Rep 2017. PMID 28798343 Free PMC article.
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. ...Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. ...
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, b …
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