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1987 2
1988 6
1989 3
1990 5
1991 10
1992 7
1993 12
1994 5
1995 7
1996 7
1997 7
1998 6
2000 4
2001 12
2002 7
2003 14
2004 7
2005 8
2006 10
2007 9
2008 2
2009 6
2010 7
2011 8
2012 9
2013 7
2014 3
2015 6
2016 5
2017 2
2018 2
2019 3
2020 0
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196 results
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Page 1
Pharmacokinetics of isoflurane in human blood.
Lu CC, et al. Pharmacology 2008 - Clinical Trial. PMID 18391509
The elimination pattern of isoflurane remains poorly quantified, and therefore this study tried to clarify the pharmacokinetic pattern of isoflurane elimination. ...Sixty minutes prior to the end of surgery, we kept a fixed 2% inspired isoflurane in 6,000 ml min(-1) oxygen flow. Isoflurane supplement was then discontinued to study the 20-min isoflurane elimination. ...
The elimination pattern of isoflurane remains poorly quantified, and therefore this study tried to clarify the pharmacokinetic
Pharmacokinetics of intravenous emulsified isoflurane in beagle dogs.
Yang XL, et al. Br J Anaesth 2013. PMID 23015620 Free article.
BACKGROUND: We previously demonstrated that i.v. emulsified isoflurane induces general anaesthesia in animals. In this study, we compared the pharmacokinetics of emulsified isoflurane given as i.v. bolus and as infusion in beagle dogs. ...CONCLUSIONS: A two-compartment model adequately describes the pharmacokinetics of emulsified isoflurane for both bolus and infusion. ...
BACKGROUND: We previously demonstrated that i.v. emulsified isoflurane induces general anaesthesia in animals. In this study, we comp …
Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in dogs.
Johnson BA, et al. Am J Vet Res 2019. PMID 31644338
Dogs were initially assigned to 1 of 2 treatments (gabapentin [20 mg/kg, PO] followed 2 hours later by anesthesia maintained with isoflurane or anesthesia maintained with isoflurane alone). ...RESULTS: Mean ± SD MAC of isoflurane was significantly lower when dogs received gabapentin and isoflurane (0.71 ± 0.12%) than when dogs received isoflurane alone (0.91 ± 0.26%). ...
Dogs were initially assigned to 1 of 2 treatments (gabapentin [20 mg/kg, PO] followed 2 hours later by anesthesia maintained with isoflur
Pharmacokinetics of isoflurane: uptake in the brain.
Lu CC, et al. Pharmacology 2003 - Clinical Trial. PMID 12928584
We studied the effect of the inspired isoflurane concentration (C(I)iso) on the pharmacokinetics of isoflurane uptake in the brain by comparing the isoflurane concentration in internal jugular-bulb blood (Jiso) with that in arterial blood (Aiso), and analyzed this by gas chromatography. ...These results demonstrate that the pharmacokinetics of isoflurane uptake in the brain is time-dependent for Jiso to equal Aiso, and the midpoint between Aiso and Jiso (likely representing the isoflurane concentration in brain tissue) was dependent on C(I)iso....
We studied the effect of the inspired isoflurane concentration (C(I)iso) on the pharmacokinetics of isoflurane uptake i …
Pharmacokinetics of desflurane, sevoflurane, isoflurane, and halothane in pigs.
Yasuda N, et al. Anesth Analg 1990. PMID 2400116
As predicted from tissue solubilities, the tissue time constants for desflurane were smaller than those for sevoflurane, isoflurane, and halothane. Recovery (normalized to that of isoflurane) of the volume of anesthetic taken up was significantly greater (P less than 0.05) for desflurane (93% +/- 7% [mean +/- SD]) than for halothane (77% +/- 6%), was not different from that of isoflurane (100%), but was less than that for sevoflurane (111% +/- 17%). ...
As predicted from tissue solubilities, the tissue time constants for desflurane were smaller than those for sevoflurane, isoflurane, …
Pharmacokinetics of isoflurane: uptake in the body.
Lu CC, et al. Pharmacology 2003 - Clinical Trial. PMID 14512699
We investigated the effect of the inspired isoflurane concentration (C(I)iso) on body uptake by comparing the isoflurane concentration in the pulmonary artery blood (PAiso) and that in the arterial blood (Aiso) in 16 patients undergoing coronary artery bypass grafting surgery during the 1st, hour of isoflurane anesthesia. ...The inspired concentration-dependent and near-constant uptake of isoflurane over time has important implications which enable us to apply the uptake pattern of isoflurane to clinical practice....
We investigated the effect of the inspired isoflurane concentration (C(I)iso) on body uptake by comparing the isoflurane conce …
EFFECTS OF TRAMADOL ON THE MINIMUM ANESTHETIC CONCENTRATION OF ISOFLURANE IN WHITE-EYED PARAKEETS (PSITTACARA LEUCOPHTHALMUS).
Escobar A, et al. J Zoo Wildl Med 2017. PMID 28749279
Isoflurane MAC was calculated as the mean isoflurane concentration value at the crossover events. After 1 wk, the same birds were reanesthetized with isoflurane and MAC was determined at 15 and 30 min after intramuscular administration of 10 mg/kg of tramadol using the same method. ...The isoflurane MAC value in white-eyed parakeets is higher than reported for other bird species. Tramadol (10 mg/kg, i.m.) does not change isoflurane MAC in these birds....
Isoflurane MAC was calculated as the mean isoflurane concentration value at the crossover events. After 1 wk, the same birds w
Awakening arterial blood and end-tidal concentrations of isoflurane in female surgical patients.
Lin TC, et al. Medicine (Baltimore) 2016. PMID 27472727 Free PMC article.
Delayed extubation occurs after isoflurane anesthesia, especially following prolonged surgical duration. We aimed to determine the arterial blood concentrations of isoflurane and the correlation with end-tidal concentrations for predicting emergence from general anesthesia.Thirty-four American Society of Anesthesiologists physical status class I-II gynecologic patients were included. General anesthesia was maintained with a fixed 2% inspiratory isoflurane in 6 L/minute oxygen, which was discontinued after surgery. ...
Delayed extubation occurs after isoflurane anesthesia, especially following prolonged surgical duration. We aimed to determine the ar …
Advantages and guidelines for using isoflurane.
Ludders JW. Vet Clin North Am Small Anim Pract 1992 - Review. PMID 1585568
Isoflurane offers many advantages over other inhalational anesthetics. Its faster induction and recovery, relative sparing effect on cardiovascular function and cerebral blood flow autoregulation, and negligible metabolism make this drug particularly useful in the anesthetic management of the debilitated, aged, or unusual veterinary patient....
Isoflurane offers many advantages over other inhalational anesthetics. Its faster induction and recovery, relative sparing effect on
A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats.
Shaughnessy MR and Hofmeister EH. Vet Anaesth Analg 2014 - Review. PMID 24034181
RESULTS: The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± 0.33%. The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. CONCLUSIONS & CLINICAL RELEVANCE: The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. ...
RESULTS: The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± …
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