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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 2
1975 13
1976 14
1977 15
1978 7
1979 6
1980 3
1981 16
1982 16
1983 29
1984 54
1985 55
1986 105
1987 140
1988 127
1989 134
1990 130
1991 186
1992 162
1993 188
1994 229
1995 237
1996 239
1997 219
1998 263
1999 200
2000 174
2001 180
2002 177
2003 182
2004 217
2005 243
2006 239
2007 230
2008 248
2009 227
2010 201
2011 226
2012 223
2013 239
2014 242
2015 239
2016 244
2017 231
2018 164
2019 95
2020 0
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6,633 results
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Page 1
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats.
Wang X, et al. Drug Des Devel Ther 2018. PMID 30613136 Free PMC article.
Recent studies have shown that dexmedetomidine can reduce isoflurane-induced neuronal injury, but the mechanism remains unclear. ...Furthermore, we examined if dexmedetomidine could decrease isoflurane-induced neurotoxicity. METHODS: Neonatal rats (postnatal day 7, n=144) were randomly divided into four groups of 36 animals each: control (saline injection without isoflurane); isoflurane (2% for 4 h); isoflurane + single dose of dexmedetomidine (75 µg/kg, 20 min before the start of 2% isoflurane for 4 h); and isoflurane + dual doses of dexmedetomidine (25 µg/kg, 20 min before and 2 h after start of isoflurane at 2% for 4 h). ...
Recent studies have shown that dexmedetomidine can reduce isoflurane-induced neuronal injury, but the mechanism remains unclear. ...F …
Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice-Assessing the degree of distress.
Hohlbaum K, et al. PLoS One 2017. PMID 28617851 Free PMC article.
However, repeated isoflurane anesthesia caused only short-term mild distress and impairment of well-being, mainly in the immediate postanesthetic period. ...However, within the mild severity category, repeated isoflurane anesthesia ranks higher than single isoflurane anesthesia. Additionally, our results imply that male and female mice can differently perceive the severity of a procedure....
However, repeated isoflurane anesthesia caused only short-term mild distress and impairment of well-being, mainly in the immediate po …
Isoflurane.
Prys-Roberts C. Br J Anaesth 1981. PMID 7317242 Free article.
The genetics of isoflurane-induced developmental neurotoxicity.
Na HS, et al. Neurotoxicol Teratol 2017. PMID 27989695 Free PMC article.
Animals were then treated with rapamycin or preconditioned with isoflurane to test effects on AIN. RESULTS: Forty-four mutations, as well as pharmacologic manipulations, identified two pathways, highly conserved from invertebrates to humans, that regulate AIN in C. elegans. ...Pharmacologic inhibition of the mechanistic Target of Rapamycin (mTOR) blocks ER-stress and AIN. Preconditioning with isoflurane prior to larval exposure also inhibited AIN. ...
Animals were then treated with rapamycin or preconditioned with isoflurane to test effects on AIN. RESULTS: Forty-four mutations, as …
Desflurane
Ball C and Westhorpe RN. Anaesth Intensive Care 2007. PMID 17933149 Free article.
Isoflurane's Effect on Intraoperative Systolic Left Ventricular Performance in Cardiac Valve Surgery Patients.
Kim JD, et al. J Korean Med Sci 2018. PMID 29318795 Free PMC article.
BACKGROUND: Isoflurane, a common anesthetic for cardiac surgery, reduced myocardial contractility in many experimental studies, few studies have determined isoflurane's direct impact on the left ventricular (LV) contractile function during cardiac surgery. We determined whether isoflurane dose-dependently reduces the peak systolic velocity of the lateral mitral annulus in tissue Doppler imaging (S') in patients undergoing cardiac surgery. ...
BACKGROUND: Isoflurane, a common anesthetic for cardiac surgery, reduced myocardial contractility in many experimental studies, few s …
The pharmacology of isoflurane.
Eger EI. Br J Anaesth 1984 - Review. PMID 6391530
The physical and pharmacological properties of the structural isomers isoflurane and enflurane differ from each other and from those of other potent inhaled anaesthetics. ...Only 0.17% of isoflurane taken up in man appears as urinary metabolites. This resistance to biodegradation may explain the minimal or absent hepatotoxicity and nephrotoxicity of isoflurane....
The physical and pharmacological properties of the structural isomers isoflurane and enflurane differ from each other and from …
Erythropoietin diminishes isoflurane-induced apoptosis in rat frontal cortex.
Ocmen E, et al. Paediatr Anaesth 2016. PMID 26921217
The aim of this study was to determine the neuroprotective effect of erythropoietin after isoflurane anesthesia in rat pups. ...Control group (GC; n = 14): Rats breathed 100% oxygen for 6 h; Isoflurane group (GI; n = 14): Rats were exposed to 1.5% isoflurane in 100% oxygen for 6 h; Isoflurane + erythropoietin group (GIE; n = 14): 1000 IU·kg(-1) (intraperitoneal; IP) Erythropoietin was administered after isoflurane anesthesia. ...
The aim of this study was to determine the neuroprotective effect of erythropoietin after isoflurane anesthesia in rat pups. ...Contr …
EFFECTS OF TRAMADOL ON THE MINIMUM ANESTHETIC CONCENTRATION OF ISOFLURANE IN WHITE-EYED PARAKEETS (PSITTACARA LEUCOPHTHALMUS).
Escobar A, et al. J Zoo Wildl Med 2017. PMID 28749279
Isoflurane MAC was calculated as the mean isoflurane concentration value at the crossover events. After 1 wk, the same birds were reanesthetized with isoflurane and MAC was determined at 15 and 30 min after intramuscular administration of 10 mg/kg of tramadol using the same method. ...The isoflurane MAC value in white-eyed parakeets is higher than reported for other bird species. Tramadol (10 mg/kg, i.m.) does not change isoflurane MAC in these birds....
Isoflurane MAC was calculated as the mean isoflurane concentration value at the crossover events. After 1 wk, the same birds w
Cardiorespiratory parameters in the awake pigeon and during anaesthesia with isoflurane.
Botman J, et al. Vet Anaesth Analg 2016 - Clinical Trial. PMID 25929705
Two weeks later, the pigeons were anaesthetized with isoflurane in order to determine their MAC and evaluate the same cardiovascular and respiratory variables during a further 40 minutes of isoflurane anaesthesia. ...CONCLUSIONS AND CLINICAL RELEVANCE: Isoflurane MAC in pigeons appeared to be higher than in other avian species. Isoflurane anaesthesia in pigeons resulted in hypercapnia, hypotension, mild hypothermia and second- and third-degree atrioventricular blocks....
Two weeks later, the pigeons were anaesthetized with isoflurane in order to determine their MAC and evaluate the same cardiovascular …
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