Adult-type granulosa cell tumor of the testis: report of a case and review of literature

Pan Afr Med J. 2017 Apr 4:26:198. doi: 10.11604/pamj.2017.26.198.11523. eCollection 2017.

Abstract

Granulosa cell tumors is classified into juvenile and adult types and comprise less than 5% of ovarian tumors in women and are much rarer in men which only 45 have been previously reported. We report here a 40-year young man with a left testicular adult type granulosa cell tumor. The tumor measured 5.5X5X4cm; Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin. Post operative CT scans shows a lomboaortic lymphnodes treated by four cycles of chemotherapy type BEP (bleomycin, etoposide, cisplatin). The thoraco abdominal CT scans post chemotherapy shows the disappearance of the right testicular nodule and the lomboaortic lymphnodes. 2 years after treatment, the patient is alive and well with no signs of recurrence. Our report highlights one more case of this very rare tumor of the testis, which is quite problematic In terms of prognosis and management, and for this reason seems to have attracted the interest of many researchers recently.

Keywords: Adult-type granulosa cell tumour; Granulosa; testis; tumour.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / therapeutic use
  • Cisplatin / therapeutic use
  • Etoposide / therapeutic use
  • Follow-Up Studies
  • Granulosa Cell Tumor / diagnostic imaging
  • Granulosa Cell Tumor / drug therapy
  • Granulosa Cell Tumor / pathology*
  • Humans
  • Male
  • Testicular Neoplasms / diagnostic imaging
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / pathology*
  • Tomography, X-Ray Computed

Substances

  • Bleomycin
  • Etoposide
  • Cisplatin

Supplementary concepts

  • BEP protocol