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Year Number of Results
1989 6
1992 1
1994 1
1995 1
1996 4
1997 19
1998 127
1999 348
2000 430
2001 402
2002 391
2003 461
2004 458
2005 508
2006 539
2007 590
2008 525
2009 564
2010 599
2011 619
2012 641
2013 724
2014 738
2015 603
2016 573
2017 570
2018 556
2019 275
2020 5
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10,224 results
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Page 1
Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs.
Di Cerbo A, et al. Sci Rep 2018. PMID 29352174 Free PMC article.
In the present study, we investigated the effect of a pharmaceutical formulation (OTC - Ossitetraciclina liquida 20%) used as antibiotic, on the mechanical properties of K562 cells by using the Micropipette Aspiration Technique (MAT). This formulation has been shown to increase in a time dependent way the inflammation and toxicity in terms of apoptosis in in vitro experiments on K562 and other types of cells. ...
In the present study, we investigated the effect of a pharmaceutical formulation (OTC - Ossitetraciclina liquida 20%) used as antibiotic, on …
Differential impact of bortezomib on HL-60 and K562 cells.
Kliková K, et al. Gen Physiol Biophys 2015. PMID 25367763
The relative resistance of K562 cells to bortezomib correlated well with significantly higher expression of HSP27, HSP70, HSP90α, HSP90β and GRP75 in these cells. ...The death of both types of cells was accompanied with proteolytic activation of caspase 3 that was observed in HL-60 cells and proteolytic degradation of procaspase 3 in K562 cells. ...
The relative resistance of K562 cells to bortezomib correlated well with significantly higher expression of HSP27, HSP70, HSP9 …
[Relationship between DNMT1 and Methylation of SHP-1 Promoter 2 in K562 Cells].
Liu XD, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018. PMID 29665905 Chinese.
The expression of SHP-1 mRNA in K562 cells transfected with psiHIV-mU6-shDNMT1 was significantly higher than that in K562 cells transfected with psiHIV-mU6-shDNMT1 (14.23±3.83 vs 1.031±0.156)(P<0.01). ...CONCLUSION: The DNMT1 in K562 cells relates with the hypermethylation and silencing of SHP-1 promoter in K562 cells....
The expression of SHP-1 mRNA in K562 cells transfected with psiHIV-mU6-shDNMT1 was significantly higher than that in K562
[Effect of HIF-1α on Angiogenesis-Related Factors in K562 Cells].
Xie YB, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019. PMID 31607301 Chinese.
OBJECTIVE: To explore the mechanisms of angiogenesis in chronic myeloid leukemia (CML) through detecting the levels of angiogenesis-related factors secreted from K562 cells after overexpression and interference of HIF-1α gene in K562 cells. METHODS: The K562 cells were transfected by lentiviruses carried and interfered HIF-1α gene, then the transtected K562 cells with carried and interfered with HIF-1α gene were enrolled in overexpression and interference groups respectively, at the same time the K562 cells transfected by the empty virus were enrolled in control group. ...
OBJECTIVE: To explore the mechanisms of angiogenesis in chronic myeloid leukemia (CML) through detecting the levels of angiogenesis-related …
[Differentiation of K562 Cells Induced by Pulsatilla Saponin A into Erythroid Lineage].
Wang T, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016. PMID 27531759 Chinese.
RESULTS: K562 cells treated with 4 µg/ml pulsatilla saponin A differentiated into the erythroid lineage. With the treatment of pulsatilla saponin A, the hemoglobin content in K562 cells increased significantly; CD71 and GPA expression on the K562 cell surface were up-regulated. CONCLUSION: Pulsatilla saponin A can induce K562 cells to differentiate into erythroid lineage....
RESULTS: K562 cells treated with 4 µg/ml pulsatilla saponin A differentiated into the erythroid lineage. With the treatment of …
[Effect of Hypoxia on the Proliferation and Hypoxia Inducible Factor-1α Expression in Human Leukemia K562 Cells].
Chen L, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018. PMID 29397817 Chinese.
METHODS: The leukemia cells were divided into 2 groups: hypoxia-treated group and conventional oxygen group as control. The K562 cells in hypoxia-treated group were treated with 50, 200, 400 and 800 µmol/L of CoCl(2), while the K562 cells in control group were cultured in conventional oxygen condition, then the K562 cells in 2 groups were colleted after treatment for 24, 48 and 72 hours. ...CONCLUSION: The hypoxia can inhibit the proliferation of K562 cells and up-requlate the expression of HIF-1α in cells, but does not induce cell differentiation....
METHODS: The leukemia cells were divided into 2 groups: hypoxia-treated group and conventional oxygen group as control. The K562
[Effect of Autophagy on Homoharringtonine-treated K562 Cells].
Lu XY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017. PMID 28446285 Chinese.
OBJECTIVE: To study the effect of homoharringtonine (HHT) alone or combined with 3-methyladenine (3-MA) , an autophagy inhibitor, on the apoptosis and autophagy of K562 cells. ...CONCLUSIONS: HHT can induce apoptosis of K562 cells, but the sustaining effect of HHT can induc autophagy of K562 cells, the combination of HHT with 3-MA may enhance the cytotoxicitic effect of HHT on K562 cells....
OBJECTIVE: To study the effect of homoharringtonine (HHT) alone or combined with 3-methyladenine (3-MA) , an autophagy inhibitor, on the apo …
[Effect of Dehydrocostus Lactone on Proliferation of K562 Cells and Its Mechanism].
Cai H, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019. PMID 31607295 Chinese.
OBJECTIVE: To explore the inhibitory effect of dehydrocostus lactone on the proliferation of human chronic myeloid leukemia K562 cells and the underlying mechanisms. ...CONCLUSION: Dehydrocostus lactone can suppress the proliferation of K562 cells and induce the apoptosis of K562 cells through BCR/ABL-STAT signaling pathways....
OBJECTIVE: To explore the inhibitory effect of dehydrocostus lactone on the proliferation of human chronic myeloid leukemia K562 c
[Overexpression of SHP-1 Enhances the Sensitivity of K562 Cells to Imatinib].
Li YH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016. PMID 26913392 Chinese.
RESULTS: After exposure of K562 cells to 0.08 µmol/L IM for 72 h, there was no significant change of SHP-1 expression in K562 cells. ...The IC50 of IM in K562(SHP-1) cells was the lower as compared with that of K562(EGFP) cells (P < 0.05) after exposure to different concentrations of IM for 72 h. ...
RESULTS: After exposure of K562 cells to 0.08 µmol/L IM for 72 h, there was no significant change of SHP-1 expression in K5
Bioinformatics Pipeline for Transcriptome Sequencing Analysis
Djebali S, et al. Methods Mol Biol 2017. PMID 27662878
We present the workflow using human transcriptome sequencing data from two biological replicates of the K562 cell line produced as part of the ENCODE3 project....
We present the workflow using human transcriptome sequencing data from two biological replicates of the K562 cell line produced as pa …
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