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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 2
2000 4
2001 11
2002 10
2003 14
2004 22
2005 18
2006 28
2007 55
2008 124
2009 233
2010 342
2011 391
2012 534
2013 586
2014 668
2015 644
2016 674
2017 632
2018 605
2019 523
2020 69
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5,391 results
Results by year
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Page 1
Small molecule combats cancer-causing KRAS protein at last.
Herbst RS, Schlessinger J. Herbst RS, et al. Nature. 2019 Nov;575(7782):294-295. doi: 10.1038/d41586-019-03242-8. Nature. 2019. PMID: 31705127 No abstract available.
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ. Bryant KL, et al. Nat Med. 2019 Apr;25(4):628-640. doi: 10.1038/s41591-019-0368-8. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833752 Free PMC article.
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.
Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. Ruscetti M, et al. Science. 2018 Dec 21;362(6421):1416-1422. doi: 10.1126/science.aas9090. Science. 2018. PMID: 30573629 Free PMC article.
Role of KRAS in regulating normal human airway basal cell differentiation.
Ogawa F, Walters MS, Shafquat A, O'Beirne SL, Kaner RJ, Mezey JG, Zhang H, Leopold PL, Crystal RG. Ogawa F, et al. Respir Res. 2019 Aug 9;20(1):181. doi: 10.1186/s12931-019-1129-4. Respir Res. 2019. PMID: 31399087 Free PMC article.
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Yao W, et al. Nature. 2019 Apr;568(7752):410-414. doi: 10.1038/s41586-019-1062-1. Epub 2019 Mar 27. Nature. 2019. PMID: 30918400 Free PMC article.
KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations.
Oka M, Kushamae M, Aoki T, Yamaguchi T, Kitazato K, Abekura Y, Kawamata T, Mizutani T, Miyamoto S, Takagi Y. Oka M, et al. World Neurosurg. 2019 Jun;126:e1365-e1373. doi: 10.1016/j.wneu.2019.03.105. Epub 2019 Mar 19. World Neurosurg. 2019. PMID: 30902772
LZTR1 is a regulator of RAS ubiquitination and signaling.
Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G. Bigenzahn JW, et al. Science. 2018 Dec 7;362(6419):1171-1177. doi: 10.1126/science.aap8210. Epub 2018 Nov 15. Science. 2018. PMID: 30442766 Free PMC article.
Progress in targeting RAS with small molecule drugs.
McCormick F. McCormick F. Biochem J. 2019 Jan 31;476(2):365-374. doi: 10.1042/BCJ20170441. Biochem J. 2019. PMID: 30705085 Review.
The Role of KRAS in Endometrial Cancer: A Mini-Review.
Sideris M, Emin EI, Abdullah Z, Hanrahan J, Stefatou KM, Sevas V, Emin E, Hollingworth T, Odejinmi F, Papagrigoriadis S, Vimplis S, Willmott F. Sideris M, et al. Anticancer Res. 2019 Feb;39(2):533-539. doi: 10.21873/anticanres.13145. Anticancer Res. 2019. PMID: 30711927 Review.
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