Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 15
1947 4
1948 6
1949 10
1950 17
1951 12
1952 21
1953 19
1954 27
1955 16
1956 18
1957 24
1958 22
1959 30
1960 36
1961 37
1962 33
1963 35
1964 63
1965 54
1966 70
1967 73
1968 86
1969 118
1970 86
1971 121
1972 117
1973 95
1974 122
1975 105
1976 109
1977 106
1978 126
1979 122
1980 119
1981 134
1982 122
1983 153
1984 131
1985 133
1986 135
1987 110
1988 102
1989 113
1990 133
1991 121
1992 93
1993 98
1994 92
1995 80
1996 91
1997 61
1998 62
1999 70
2000 50
2001 71
2002 58
2003 61
2004 58
2005 54
2006 64
2007 76
2008 71
2009 49
2010 49
2011 62
2012 67
2013 58
2014 69
2015 61
2016 72
2017 73
2018 75
2019 27
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

5,209 results
Results by year
Filters applied: . Clear all
Page 1
Ketone bodies as signaling metabolites.
Newman JC and Verdin E. Trends Endocrinol Metab 2014 - Review. PMID 24140022 Free PMC article.
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. ...We review the regulation and functions of ketone bodies, the relationship between ketone bodies and calorie restriction, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging....
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues …
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P and Crawford PA. Cell Metab 2017 - Review. PMID 28178565 Free PMC article.
Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. ...
Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone
Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation.
Evans M, et al. J Physiol 2017 - Review. PMID 27861911 Free PMC article.
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, and the ability to utilise ketone bodies is higher in exercise-trained skeletal muscle. ...The present review focuses on the physiology of ketone bodies during and after exercise and in response to training, with specific interest in exploring the physiological basis for exogenous ketone supplementation and potential benefits for performance and recovery in athletes....
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, a
Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?
Pinckaers PJ, et al. Sports Med 2017. PMID 27430501 Free PMC article.
Recently, there has been a re-emerging interest in the role of ketone bodies in exercise metabolism, with considerable media speculation about ketone body supplements being routinely used by professional cyclists. Ketone bodies can serve as an important energy substrate under certain conditions, such as starvation, and can modulate carbohydrate and lipid metabolism. ...
Recently, there has been a re-emerging interest in the role of ketone bodies in exercise metabolism, with considerable media s …
Ketone bodies mimic the life span extending properties of caloric restriction.
Veech RL, et al. IUBMB Life 2017 - Review. PMID 28371201 Free article.
In addition, the metabolism of ketone bodies results in a more negative redox potential of the NADP antioxidant system, which is a terminal destructor of oxygen free radicals. ...We hypothesize that increasing the levels of ketone bodies will also extend the life span of humans and that calorie restriction extends life span at least in part through increasing the levels of ketone bodies. ...
In addition, the metabolism of ketone bodies results in a more negative redox potential of the NADP antioxidant system, which …
Ketone bodies as epigenetic modifiers.
Ruan HB and Crawford PA. Curr Opin Clin Nutr Metab Care 2018 - Review. PMID 29697540
Although it remains to be fully established whether these changes to the epigenome are attributable to ketone bodies themselves or other aspects of ketotic states, the regulated genes mediate classical responses to carbohydrate restriction. SUMMARY: Direct regulation of gene expression may occur in-vivo via through ketone body-mediated histone modifications during adherence to low-carbohydrate diets, fasting ketosis, exogenous ketone body therapy, and diabetic ketoacidosis. ...
Although it remains to be fully established whether these changes to the epigenome are attributable to ketone bodies themselve …
Effects of Ketone Bodies on Endurance Exercise.
Sansone M, et al. Curr Sports Med Rep 2018 - Review. PMID 30531462
For this reason, using ketone esters and/or salts have been proposed to obtain nutritional ketosis without limiting carbohydrate intake. ...
For this reason, using ketone esters and/or salts have been proposed to obtain nutritional ketosis without limiting carbohydrate inta …
Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?
Simeone TA, et al. Neuropharmacology 2018 - Review. PMID 29325899 Free PMC article.
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet (KD) remain unclear, a long-standing question has been whether ketone bodies (i.e., β-hydroxybutyrate, acetoacetate and acetone), either alone or in combination, contribute mechanistically. ...This review summarizes recent novel experimental findings supporting the anti-seizure and neuroprotective properties of ketone bodies....
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet (KD) remain unclear, a long-standing question has …
Ketone Bodies as Anti-Seizure Agents.
Simeone TA, et al. Neurochem Res 2017 - Review. PMID 28397070 Free PMC article.
There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. ...Nevertheless, the notion that KB are themselves anti-seizure agents requires clinical validation, as prior studies have not revealed a clear correlation between blood ketone levels and seizure control. ...
There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption …
Metabolic regulation of NLRP3
Hughes MM and O'Neill LAJ. Immunol Rev 2018 - Review. PMID 29247992
The NLRP3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. ...
The NLRP3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ket
5,209 results
Jump to page
Feedback