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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1951 7
1952 12
1953 23
1954 27
1955 12
1956 21
1957 24
1958 16
1959 18
1960 20
1961 24
1962 15
1963 2
1964 13
1965 24
1966 81
1967 89
1968 124
1969 144
1970 138
1971 158
1972 156
1973 141
1974 165
1975 143
1976 130
1977 141
1978 155
1979 137
1980 129
1981 147
1982 122
1983 167
1984 154
1985 157
1986 159
1987 124
1988 122
1989 127
1990 142
1991 126
1992 106
1993 112
1994 103
1995 88
1996 100
1997 63
1998 94
1999 137
2000 110
2001 125
2002 123
2003 136
2004 131
2005 133
2006 151
2007 144
2008 146
2009 127
2010 144
2011 163
2012 180
2013 178
2014 190
2015 204
2016 191
2017 213
2018 195
2019 127
2020 1
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7,361 results
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Page 1
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P and Crawford PA. Cell Metab 2017 - Review. PMID 28178565 Free PMC article.
Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. ...Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations....
Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone
Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation.
Evans M, et al. J Physiol 2017 - Review. PMID 27861911 Free PMC article.
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, and the ability to utilise ketone bodies is higher in exercise-trained skeletal muscle. ...The present review focuses on the physiology of ketone bodies during and after exercise and in response to training, with specific interest in exploring the physiological basis for exogenous ketone supplementation and potential benefits for performance and recovery in athletes....
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, a
Ketone bodies as signaling metabolites.
Newman JC and Verdin E. Trends Endocrinol Metab 2014 - Review. PMID 24140022 Free PMC article.
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. ...We review the regulation and functions of ketone bodies, the relationship between ketone bodies and calorie restriction, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging....
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues …
Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer
Vergati M, et al. Curr Med Chem 2017 - Review. PMID 28093985
Pre-clinical and clinical studies have investigated the role of a dysregulated metabolism in the sustainability of tumor initiation and progression. ...The rationale of KD is valid both because it lowers carbohydrate uptake possibly leading to cancer cell starvation and apoptosis and, at the same time, increases the levels of ketone bodies available for energy production in normal cells but not in cancer cells which have an allegedly downregulated oxidative phosphorylation. ...
Pre-clinical and clinical studies have investigated the role of a dysregulated metabolism in the sustainability of tumor initiation a …
Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.
Fukao T, et al. Prostaglandins Leukot Essent Fatty Acids 2004 - Review. PMID 14769483
Ketone bodies become major body fuels during fasting and consumption of a high-fat, low-carbohydrate (ketogenic) diet. Hyperketonemia is associated with potential health benefits. ...The utilization of ketone bodies (ketolysis) also determines circulating ketone body levels. Consideration of ketone body metabolism reveals the mechanisms underlying the extreme fragility of dietary ketosis to carbohydrate intake and highlights areas for further study....
Ketone bodies become major body fuels during fasting and consumption of a high-fat, low-carbohydrate (ketogenic) diet. Hyperke
β-Hydroxybutyrate: A signaling metabolite in starvation response?
Rojas-Morales P, et al. Cell Signal 2016 - Review. PMID 27083590
Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. ...We briefly summarize the metabolism and emerging physiological functions of ketone bodies and highlight the potential role for BHB as a signaling molecule in starvation response....
Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolong
Hyperpolarized ketone body metabolism in the rat heart.
Miller JJ, et al. NMR Biomed 2018. PMID 29637642 Free PMC article.
Their metabolism was studied in isolated, perfused rat hearts. Hyperpolarized [1-(13) C]acetoacetate metabolism was also studied in the in vivo rat heart in the fed and fasted states. ...These preliminary investigations show that DNP can be used as an effective in vivo probe of ketone body metabolism in the heart....
Their metabolism was studied in isolated, perfused rat hearts. Hyperpolarized [1-(13) C]acetoacetate metabolism was also studi …
Ketone body metabolism and sleep homeostasis in mice.
Chikahisa S, et al. Neuropharmacology 2014. PMID 24361452
The present study investigated the role of ketone bodies in sleep regulation. Six-hour sleep deprivation increased plasma ketone bodies and their ratio (acetoacetate/β-hydroxybutyrate) in 10-week-old male mice. ...Central metabolism of ketone bodies, especially acetoacetate, appears to play a role in the regulation of sleep homeostasis....
The present study investigated the role of ketone bodies in sleep regulation. Six-hour sleep deprivation increased plasma k
Metabolism of ketone bodies in pregnant sheep.
Pethick DW and Lindsay DB. Br J Nutr 1982. PMID 6926736
There was incomplete interconversion of D(-) 3-hydroxybutyrate (3HB) and acetoacetate (AcAc) and therefore neither entry rate nor oxidation of total ketone bodies could be estimated by assuming circulating ketone bodies represent a single metabolic compartment. ...A two-compartment model was used to analyse ketone body metabolism by hind-limb skeletal muscle. The results suggested substantial interconversion and production of AcAc and 3HB. 5. ...
There was incomplete interconversion of D(-) 3-hydroxybutyrate (3HB) and acetoacetate (AcAc) and therefore neither entry rate nor oxidation …
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