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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 3
1979 8
1980 7
1981 10
1982 25
1983 37
1984 46
1985 56
1986 55
1987 60
1988 45
1989 51
1990 62
1991 53
1992 62
1993 65
1994 60
1995 63
1996 96
1997 85
1998 75
1999 94
2000 112
2001 128
2002 123
2003 126
2004 151
2005 190
2006 175
2007 193
2008 213
2009 173
2010 205
2011 204
2012 174
2013 204
2014 210
2015 177
2016 178
2017 139
2018 124
2019 47
2020 0
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4,054 results
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Human natural killer cells.
Caligiuri MA. Blood 2008 - Review. PMID 18650461 Free PMC article.
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in our understanding of what and how NK-cells "see," lending important insights into their functions and purpose in normal immune surveillance. ...
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that b
Development and maturation of natural killer cells.
Geiger TL and Sun JC. Curr Opin Immunol 2016 - Review. PMID 26845614 Free PMC article.
Natural killer (NK) cells are innate lymphocytes that are critical for host protection against pathogens and cancer due to their ability to rapidly release inflammatory cytokines and kill infected or transformed cells. ...We now know that NK cells are the founding members of an expanded family of lymphocyte known as innate lymphoid cells (ILC). ...
Natural killer (NK) cells are innate lymphocytes that are critical for host protection against pathogens and cancer due
The Molecular Imaging of Natural Killer Cells.
Shapovalova M, et al. Mol Imaging 2018 - Review. PMID 30203710 Free PMC article.
Identified nearly 4 decades ago, natural killer (NK) cells represent an arguably better cell type for immunotherapy development. Natural killer cells are cytotoxic lymphocytes that mediate the direct killing of transformed cells with reduced or absent major histocompatibility complex (MHC) and are the effector cells in antibody-dependent cell-mediated cytotoxicity. ...
Identified nearly 4 decades ago, natural killer (NK) cells represent an arguably better cell type for immunotherapy dev …
Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys.
Huot N, et al. Nat Med 2017. PMID 29035370 Free PMC article.
Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary lymphoid organs is incomplete. ...These follicles were strongly positive for IL-15, which was primarily presented in its membrane-bound form by follicular dendritic cells. ...
Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary ly
Natural killer cells in sepsis: Underprivileged innate immune cells.
Kumar V. Eur J Cell Biol 2019 - Review. PMID 30583806
Natural Killer (NK) cells are highly recognized potent innate immune cells that play a very important role in the generation of an antiviral and antitumor immune response. These are also unique innate immune cells due to the existence of NK cell-mediated memory due to the process of education and learning as shown by the cells of adaptive immunity. ...
Natural Killer (NK) cells are highly recognized potent innate immune cells that play a very important role in th
Markers and function of human NK cells in normal and pathological conditions.
Del Zotto G, et al. Cytometry B Clin Cytom 2017 - Review. PMID 28054442 Free article.
Natural killer (NK) cells, the most important effectors of the innate lymphoid cells (ILCs), play a fundamental role in tumor immune-surveillance, defense against viruses and, in general, in innate immune responses. ...To prevent healthy cells from auto-aggression, NK cells are provided with strong inhibitory receptors (KIRs and NKG2A) which recognize HLA class I molecules on target cells and, sensing their level of expression, allow killing of targets underexpressing HLA-class I. ...
Natural killer (NK) cells, the most important effectors of the innate lymphoid cells (ILCs), play a fundamental
Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy.
Senju H, et al. Int J Biol Sci 2018. PMID 29559850 Free PMC article.
Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we examined the effect of IL-18 on NK cells derived from lung cancer patients and healthy adult volunteers. When peripheral blood NK cells were stimulated with IL-2, the cells formed clusters beginning on day 5-6 and proliferated thereafter, in which the number of NK cells increased by 10-fold in 10 days. ...
Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. …
Application of Mass Cytometry (CyTOF) for Functional and Phenotypic Analysis of Natural Killer Cells.
Kay AW, et al. Methods Mol Biol 2016. PMID 27177653 Free PMC article.
Mass cytometry is a novel platform for high-dimensional phenotypic and functional analysis of single cells. This system uses elemental metal isotopes conjugated to monoclonal antibodies to evaluate up to 42 parameters simultaneously on individual cells with minimal overlap between channels. ...Here, we will describe methods to stain, collect, and analyze intracellular functional markers and surface phenotypic markers on natural killer cells....
Mass cytometry is a novel platform for high-dimensional phenotypic and functional analysis of single cells. This system uses elementa …
Engineering Receptor Expression on Natural Killer Cells Through Trogocytosis.
Somanchi A, et al. Methods Mol Biol 2016. PMID 27177672
Trogocytosis is a rapid contact-dependent process by which lymphocytes acquire membrane patches from the target cells ('donor' cells) with which they interact and this phenomenon has been shown to occur in various immune cells. The surface molecules acquired through trogocytosis are functionally incorporated in the 'acceptor' cells transiently. We had previously demonstrated that trogocytosis can be utilized in place of gene transfer to engineer surface receptor expression on NK cells for adoptive immunotherapy applications. ...
Trogocytosis is a rapid contact-dependent process by which lymphocytes acquire membrane patches from the target cells ('donor' cel
Isolation of Non-parenchymal Cells from the Mouse Liver.
Mohar I, et al. Methods Mol Biol 2015. PMID 26450375
Using this method, liver sinusoidal endothelial cells, Kupffer cells, natural killer (NK) and NK-T cells, dendritic cells, CD4+ and CD8+ T cells, and quiescent hepatic stellate cells can be purified. ...The isolated cells are suitable for flow cytometry, protein, and mRNA analyses as well as primary culture....
Using this method, liver sinusoidal endothelial cells, Kupffer cells, natural killer (NK) and NK-T cells, …
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