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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 20
1978 70
1979 133
1980 147
1981 196
1982 253
1983 451
1984 383
1985 456
1986 473
1987 488
1988 499
1989 556
1990 471
1991 384
1992 348
1993 353
1994 376
1995 350
1996 376
1997 331
1998 345
1999 404
2000 406
2001 433
2002 413
2003 428
2004 487
2005 562
2006 534
2007 606
2008 601
2009 472
2010 479
2011 546
2012 518
2013 574
2014 613
2015 598
2016 598
2017 548
2018 541
2019 227
2020 3
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17,145 results
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Page 1
Functions of natural killer cells.
Vivier E, et al. Nat Immunol 2008 - Review. PMID 18425107
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage. Recent research highlights the fact that NK cells are also regulatory cells engaged in reciprocal interactions with dendritic cells, macrophages, T cells and endothelial cells. ...
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and
Human natural killer cells.
Caligiuri MA. Blood 2008 - Review. PMID 18650461 Free PMC article.
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in our understanding of what and how NK-cells "see," lending important insights into their functions and purpose in normal immune surveillance. ...
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that b
The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy.
Souza-Fonseca-Guimaraes F, et al. Trends Immunol 2019 - Review. PMID 30639050
Current therapies block inhibitory pathways in tumor-infiltrating CD8(+) T cells and recent studies have shown similar programs in other effector populations such as natural killer (NK) cells. NK cells are critical for immunosurveillance, particularly the control of metastatic cells or hematological cancers. However, how NK cells specifically recognize transformed cells and dominant negative feedback pathways, as well as how tumors escape NK cell control, remains undefined. ...
Current therapies block inhibitory pathways in tumor-infiltrating CD8(+) T cells and recent studies have shown similar programs in ot …
Innate or adaptive immunity? The example of natural killer cells.
Vivier E, et al. Science 2011 - Review. PMID 21212348 Free PMC article.
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. ...Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. ...
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms.
Backes CS, et al. J Biol Chem 2018. PMID 30190323 Free PMC article.
We describe a time-resolved single-cell assay that reports the quality, quantity, and kinetics of target cell death induced by single primary human natural killer (NK) cells. ...Ca(2+) influx through Orai channels is important for tuning killer cell function. We found that the apoptosis/necrosis ratio of cancer cell death by NK cells is controlled by the magnitude of Ca(2+) entry and furthermore by the relative concentrations of perforin and granzyme B. ...
We describe a time-resolved single-cell assay that reports the quality, quantity, and kinetics of target cell death induced by single primar …
Natural killer cells in lung transplantation.
Calabrese DR, et al. Thorax 2019 - Review. PMID 30381399 Free PMC article.
Natural killer (NK) cells are innate lymphoid cells that have been increasingly recognised as important in lung allograft tolerance and immune defence. ...NK cells can promote tolerance, such as through the depletion of donor antigen-presenting cells. Alternatively, these cells can drive rejection through cytotoxic effects on allograft tissue recognised as 'non-self' or 'stressed', via killer cell immunoglobulin-like receptor (KIR) or NKG2D receptor ligation, respectively. ...
Natural killer (NK) cells are innate lymphoid cells that have been increasingly recognised as important in lung
Humanized mouse model supports development, function, and tissue residency of human natural killer cells.
Herndler-Brandstetter D, et al. Proc Natl Acad Sci U S A 2017. PMID 29078283 Free PMC article.
However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. ...Transplantation of human hematopoietic stem and progenitor cells into SRG-15 mice dramatically improved the development and functional maturation of circulating and tissue-resident human NK and CD8(+) T cells and promoted the development of tissue-resident innate lymphoid cell (ILC) subsets. ...
However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicab …
Natural Killer Cell Memory.
O'Sullivan TE, et al. Immunity 2015 - Review. PMID 26488815 Free PMC article.
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. ...
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond
The Broad Spectrum of Human Natural Killer Cell Diversity.
Freud AG, et al. Immunity 2017 - Review. PMID 29166586 Free PMC article.
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For decades it has been appreciated that two major NK cell subsets (CD56(bright) and CD56(dim)) exist in humans and have distinct anatomical localization patterns, phenotypes, and functions in immunity. ...The recent discoveries of tissue-resident NK cell developmental intermediates, non-NK innate lymphoid cells, and the capacity for NK cells to adapt and differentiate into long-lived memory cells has added further complexity to this field. ...
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For decades it has been appreciat
Natural killer cells as modulators of alloimmune responses.
Mbiribindi B, et al. Curr Opin Organ Transplant 2019 - Review. PMID 30480641
PURPOSE OF REVIEW: Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and are important in host defense to virally infected and transformed cells. ...Furthermore, NK cells respond to cells infected with cytomegalovirus and Epstein-Barr virus, and studies suggest some NK cells have immune memory. ...
PURPOSE OF REVIEW: Natural killer (NK) cells are effector cells of the innate immune system that can lyse target …
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