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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1985 5
1986 12
1987 14
1988 22
1989 32
1990 28
1991 22
1992 24
1993 17
1994 18
1995 13
1996 2
1997 4
1998 5
1999 4
2000 6
2001 6
2002 3
2003 9
2004 14
2005 12
2006 13
2007 14
2008 16
2009 18
2010 15
2011 16
2012 15
2013 17
2014 16
2015 21
2016 30
2017 23
2018 21
2019 8
2020 1
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487 results
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Page 1
Natural killer cells and other innate lymphoid cells in cancer.
Chiossone L, et al. Nat Rev Immunol 2018 - Review. PMID 30209347
Most immunomodulatory strategies focus on enhancing T cell responses, but there has been a recent surge of interest in harnessing the relatively underexplored natural killer (NK) cell compartment for therapeutic interventions. NK cells show cytotoxic activity against diverse tumour cell types, and some of the clinical approaches originally developed to increase T cell cytotoxicity may also activate NK cells. ...
Most immunomodulatory strategies focus on enhancing T cell responses, but there has been a recent surge of interest in harnessing the relati …
Selection and expansion of natural killer cells for NK cell-based immunotherapy.
Becker PS, et al. Cancer Immunol Immunother 2016 - Review. PMID 26810567 Free PMC article.
Natural killer (NK) cells have been used in several clinical trials as adaptive immunotherapy. The low numbers of these cells in peripheral blood mononuclear cells (PBMC) have resulted in various approaches to preferentially expand primary NK cells from PBMC. ...Thus, expansion strategies have been focused either to substitute these factors using autologous feeder cells or to use genetically modified allogeneic feeder cells. ...
Natural killer (NK) cells have been used in several clinical trials as adaptive immunotherapy. The low numbers of these
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Fu B, et al. Immunity 2017. PMID 29262349 Free article.
Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. ...These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy....
Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. Howe
Natural Killer Cells: Angels and Devils for Immunotherapy.
Martín-Antonio B, et al. Int J Mol Sci 2017 - Review. PMID 28850071 Free PMC article.
In recent years, the relevance of the immune system to fight cancer has led to the development of immunotherapy, including the adoptive cell transfer of immune cells, such as natural killer (NK) cells and chimeric antigen receptors (CAR)-modified T cells. The discovery of donor NK cells' anti-tumor activity in acute myeloid leukemia patients receiving allogeneic stem cell transplantation (allo-SCT) was the trigger to conduct many clinical trials infusing NK cells. ...
In recent years, the relevance of the immune system to fight cancer has led to the development of immunotherapy, including the adoptive cell …
Natural killer cell-based immunotherapy: From transplantation toward targeting cancer stem cells.
Dianat-Moghadam H, et al. J Cell Physiol 2018 - Review. PMID 30144312
Natural killer (NK) cells are key players of the innate immune system. NK cells provide protection against infectious pathogens and malignancies in cell. ...The growth, recurrence, and metastasis of cancer cells, and the failure of cytoreductive therapies against cancer cells are due to the small population of intratumor stem-like cells, called cancer stem cells (CSCs). ...
Natural killer (NK) cells are key players of the innate immune system. NK cells provide protection against infec
Therapeutic Potential of Natural Killer Cells in Gastric Cancer.
Du Y and Wei Y. Front Immunol 2019 - Review. PMID 30719024 Free PMC article.
Natural killer (NK) cells, which are known as important lymphocytes in innate immunity, play vital roles in suppressing GC initiation, progression, and metastases. ...In this review, we summarize recent advancements in the relationship between NK cells and GC and point out all the innovative strategies that can enhance NK cells' function to inhibit the growth of GC....
Natural killer (NK) cells, which are known as important lymphocytes in innate immunity, play vital roles in suppressing
Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells.
Bachanova V, et al. Cancer Immunol Immunother 2018 - Clinical Trial. PMID 29218366 Free PMC article.
We report a novel phase 2 clinical trial in patients with poor prognosis refractory non-Hodgkin lymphoma (NHL) testing the efficacy of haploidentical donor natural killer (NK) cell therapy (NK dose 0.5-3.27 × 10(7) NK cells/kg) with rituximab and IL-2 (clinicaltrials.gov NCT01181258). ...Circulating donor NK cells persisted for at least 7 days after infusion at the level 0.6-16 donor NK cells/µl or 0.35-90% of total CD56 cells. ...
We report a novel phase 2 clinical trial in patients with poor prognosis refractory non-Hodgkin lymphoma (NHL) testing the efficacy of haplo …
Exploitation of natural killer cells for the treatment of acute leukemia.
Handgretinger R, et al. Blood 2016 - Review. PMID 27207791
Natural killer (NK) cells play an important role in surveillance and elimination of malignant cells. Their spontaneous cytotoxicity was first demonstrated in vitro against leukemia cell lines, and NK cells might play a crucial role in the therapy of leukemia. ...In this regard, NK cells that express an inhibitory killer immunoglobulin-like receptor (iKIR) for which the respective major histocompatibility complex class I ligand is absent on leukemic target cells can exert alloreactivity in vitro and in vivo. ...
Natural killer (NK) cells play an important role in surveillance and elimination of malignant cells. Their spont
Haploidentical Natural Killer Cells Infused before Allogeneic Stem Cell Transplantation for Myeloid Malignancies: A Phase I Trial.
Lee DA, et al. Biol Blood Marrow Transplant 2016 - Clinical Trial. PMID 27090958 Free PMC article.
Alloreactive natural killer (NK) cells mediate a potent antileukemic effect and may also enhance engraftment and reduce graft-versus-host disease (GVHD). ...The goal of infusing third-party alloreactive NK cells was to augment the antileukemic effect of the transplantation without worsening GVHD and, thus, improve the overall outcome of hematopoietic transplantation. ...
Alloreactive natural killer (NK) cells mediate a potent antileukemic effect and may also enhance engraftment and reduce …
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