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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 2
1989 11
1990 19
1991 18
1992 13
1993 24
1994 30
1995 48
1996 54
1997 72
1998 103
1999 105
2000 112
2001 121
2002 120
2003 125
2004 159
2005 198
2006 243
2007 241
2008 315
2009 369
2010 431
2011 485
2012 566
2013 568
2014 577
2015 601
2016 505
2017 486
2018 395
2019 200
2020 6
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6,487 results
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Page 1
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.
Finley LWS, et al. Nat Cell Biol 2018. PMID 29662175 Free PMC article.
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. ...In metastable ESCs, Brd4 independence can be achieved by increased expression of pluripotency transcription factors, including STAT3, Nanog or Klf4, so long as the DNA methylcytosine oxidases Tet1 and Tet2 are present. ...
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recent …
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming.
Stadhouders R, et al. Nat Genet 2018. PMID 29335546 Free PMC article.
Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors (TFs) OCT4, SOX2, KLF4 and MYC offers an opportunity to address this question but is severely limited by the low proportion of responding cells. ...Together, our results implicate genome topology as an instructive force for implementing transcriptional programs and cell fate in mammals....
Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors (TFs) OCT4, SOX2, KLF4 and MYC …
Krϋppel-like factors (KLFs) in renal physiology and disease.
Rane MJ, et al. EBioMedicine 2019 - Review. PMID 30662001 Free PMC article.
Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applications of these KLF proteins. ...
Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss phy …
Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells.
Yamane M, et al. Development 2018. PMID 29739838 Free article.
Krüppel-like factors (Klfs) have a pivotal role in maintaining self-renewal of mouse embryonic stem cells (mESCs). The functions of three Klf family members (Klf2, Klf4 and Klf5) have been identified, and are suggested to largely overlap. ...However, some particular combinations of transcription factors were capable of the restoration. The triple-knockout mESCs were successfully captured at primed state. ...
Krüppel-like factors (Klfs) have a pivotal role in maintaining self-renewal of mouse embryonic stem cells (mESCs). The functio …
GLIS1-3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases.
Jetten AM. Cell Mol Life Sci 2018 - Review. PMID 29779043 Free PMC article.
Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. ...
Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regul …
KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control.
Dhaliwal NK, et al. Genes Dev 2019. PMID 31221664 Free PMC article.
Embryonic stem (ES) cells are regulated by a network of transcription factors that maintain the pluripotent state. Differentiation relies on down-regulation of pluripotency transcription factors disrupting this network. While investigating transcriptional regulation of the pluripotency transcription factor Kruppel-like factor 4 (Klf4), we observed that homozygous deletion of distal enhancers caused a 17-fold decrease in Klf4 transcript but surprisingly decreased protein levels by less than twofold, indicating that posttranscriptional control of KLF4 protein overrides transcriptional control. ...
Embryonic stem (ES) cells are regulated by a network of transcription factors that maintain the pluripotent state. Differentia …
Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
Roberts AW, et al. Immunity 2017. PMID 29150239 Free PMC article.
Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll-like receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms. ...The transcription factors KLF2 and KLF4 control the expression of many genes within this AC clearance program. The coordinated expression of AC receptors with genes that limit responses to nucleic acids might ensure maintenance of homeostasis and thus represent a central feature of tissue macrophages....
Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll-like receptors (TLRs), engulfment of ACs does not …
Chromatin Accessibility Dynamics during iPSC Reprogramming
Li D, et al. Cell Stem Cell 2017. PMID 29220666 Free article.
Factors/conditions known to impede reprogramming prevent OSK-driven OC and skew OC-CO dynamics. While the CO loci are enriched for OSK motifs, the OC loci are not, suggesting alternative mechanisms for chromatin closing. ...
Factors/conditions known to impede reprogramming prevent OSK-driven OC and skew OC-CO dynamics. While the CO loci are enriched for OS
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Pan Y, et al. J Clin Invest 2019. PMID 30667374 Free PMC article.
Mechanistically, mature adipocyte-secreted exosomes transported miR-34a into macrophages, thereby suppressing M2 polarization by repressing the expression of Krüppel-like factor 4 (Klf4). ...
Mechanistically, mature adipocyte-secreted exosomes transported miR-34a into macrophages, thereby suppressing M2 polarization by repressing …
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