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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 10
1991 32
1992 40
1993 66
1994 84
1995 122
1996 109
1997 150
1998 149
1999 148
2000 198
2001 181
2002 174
2003 206
2004 188
2005 231
2006 327
2007 390
2008 472
2009 470
2010 466
2011 561
2012 657
2013 638
2014 627
2015 628
2016 593
2017 584
2018 546
2019 231
2020 6
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8,254 results
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Page 1
Kruppel-like factors in muscle health and disease.
Prosdocimo DA, et al. Trends Cardiovasc Med 2015 - Review. PMID 25528994 Free PMC article.
Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. ...
Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators
Kruppel-like Pluripotency Factors as Modulators of Cancer Cell Therapeutic Responses.
Farrugia MK, et al. Cancer Res 2016 - Review. PMID 26964625 Free PMC article.
Kruppel-like transcription factors, including KLF4 and KLF5, are rarely affected by genetic alteration during tumorigenesis, but compose key components of the stress response machinery in normal and tumor cells and interact with critical survival pathways, including RAS, p53, survivin, and the BCL2 family of cell death regulators. ...These factors can be preferentially expressed in embryonic stem cells or cancer stem-like cells. Indeed, specific KLFs represent key components of a cross-regulating pluripotency network in embryonic stem cells and induce pluripotency when coexpressed in adult cells with other Yamanaka factors. ...
Kruppel-like transcription factors, including KLF4 and KLF5, are rarely affected by genetic alteration during tu
Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.
Ilsley MD, et al. Nucleic Acids Res 2017. PMID 28541545 Free PMC article.
Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable N-terminal domain responsible for recruiting cofactors. ...KLF1 and related family members function as transcriptional activators via recruitment of co-activators such as EP300, whereas KLF3 and related members act as transcriptional repressors via recruitment of C-terminal Binding Proteins. ...
Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a conserved DNA-binding do …
The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease.
O'Connor L, et al. Yale J Biol Med 2016 - Review. PMID 28018142 Free PMC article.
Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm for a ubiquitously expressed transcription factor and is involved in regulating the expression of genes associated with a wide range of cellular processes in mammalian cells. Sp1 can interact with a range of proteins, including other transcription factors, members of the transcription initiation complex and epigenetic regulators, enabling tight regulation of its target genes. ...
Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm for a ubiquitously expressed t
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity.
Fan L, et al. Pharmacol Res 2018 - Review. PMID 29288718
Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the absence of this transcription factor contributes to severe pathologies such as Duchenne muscular dystrophy and heart failure. This review highlights KLF15's role as a central regulator of BCAA metabolism during periods of fasting, throughout day/night cycles, and in experimental models of muscle disease....
Krüppel-like factor 15 (KLF15) has recently emerged as a critical transcriptional regulator of BCAA metabolism, and the …
Prediction and Identification of Krüppel-Like Transcription Factors by Machine Learning Method.
Liao Z, et al. Comb Chem High Throughput Screen 2017. PMID 28292252
AIM AND OBJECTIVE: The Krüppel-like factors (KLFs) are a family of containing Zn finger(ZF) motif transcription factors with 18 members in human genome, among them, KLF18 is predicted by bioinformatics. ...
AIM AND OBJECTIVE: The Krüppel-like factors (KLFs) are a family of containing Zn finger(ZF) motif transcription fact
Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.
Zhang X, et al. Cancer Discov 2018. PMID 28963353 Free PMC article.
The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Krüppel-like factor 5 gene (KLF5) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. ...
The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cance …
Role of kruppel-like transcription factors in adipogenesis.
Wu Z and Wang S. Dev Biol 2013 - Review. PMID 23142072 Free article.
The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological and pathological processes including cell proliferation, differentiation, inflammation, and apoptosis. ...This review summarizes the role of KLFs in lipid metabolism, especially in adipogenesis, and reveals the relationship networks among members of KLF family in differentiation....
The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological …
SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim CK, et al. Gastroenterology 2017 - Review. PMID 28366734 Free PMC article.
Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. ...
Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that co …
Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors.
Sangwung P, et al. Vasc Med 2017. PMID 28825355 Free PMC article.
We sought to elucidate the transcriptional regulation of HBA expression in the EC. Gain of KLF2 or KLF4 function studies led to significant induction of HBA in ECs. ...
We sought to elucidate the transcriptional regulation of HBA expression in the EC. Gain of KLF2 or KLF4 function studies led to signi …
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