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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 6
1974 5
1975 8
1976 8
1977 8
1978 10
1979 7
1980 5
1981 13
1982 6
1983 8
1984 12
1985 17
1986 6
1987 9
1988 25
1989 19
1990 26
1991 39
1992 29
1993 24
1994 39
1995 33
1996 33
1997 24
1998 18
1999 28
2000 19
2001 29
2002 39
2003 36
2004 23
2005 26
2006 22
2007 27
2008 18
2009 20
2010 15
2011 21
2012 36
2013 20
2014 32
2015 22
2016 31
2017 32
2018 26
2019 11
2020 0
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936 results
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Page 1
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury.
Sato K, et al. Am J Pathol 2016 - Review. PMID 27452297 Free PMC article.
Activated Kupffer cells secrete various mediators, including cytokines and chemokines, to initiate immune responses, inflammation, or recruitment of other liver cells. ...Various mediators produced by other liver cells can regulate Kupffer cell activation, which suggest that Kupffer cells orchestrate with other liver cells to relay inflammatory signals and to maintain liver homeostasis during BDL-induced liver injury. ...
Activated Kupffer cells secrete various mediators, including cytokines and chemokines, to initiate immune responses, inflammat …
Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease.
Wenfeng Z, et al. Ann Hepatol 2014 - Review. PMID 25152980 Free article.
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) pathways as a result of lipopolysaccharide (LPS) recognition by Toll-like receptor 4 (TLR4). ...
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in …
Contribution of Kupffer cells to liposome accumulation in the liver.
Samuelsson E, et al. Colloids Surf B Biointerfaces 2017. PMID 28719856 Free PMC article.
In this study, we have compared two strategies for reducing nanoparticle accumulation in the liver, in order to investigate the specific contribution of Kupffer cells. ...The results indicate that liposome pegylation is a more effective strategy for avoiding liver uptake compared to depletion of Kupffer cells, suggesting that nanoparticle interactions with other cells in the liver may also play a contributing role. ...
In this study, we have compared two strategies for reducing nanoparticle accumulation in the liver, in order to investigate the specific con …
Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity.
Rose KA, et al. J Pharm Sci 2016. PMID 26869439 Free PMC article.
We have established an in vitro rat donor-matched hepatocyte and Kupffer cell co-culture (HKCC) model to study immune-related responses to drug exposure. ...
We have established an in vitro rat donor-matched hepatocyte and Kupffer cell co-culture (HKCC) model to study immune-related respons …
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice.
Yang X, et al. Oncotarget 2016. PMID 26716516 Free PMC article.
Blocking Kupffer cells decreased MSCs migration in old mice. In vitro, Kupffer cells isolated from old mice secreted more inflammatory cytokines and chemokines. Thus, hyper-activation of Kupffer cells in old mice increased recruitment of MSCs after their therapeutic administration....
Blocking Kupffer cells decreased MSCs migration in old mice. In vitro, Kupffer cells isolated from old mice secr …
Effect of removing Kupffer cells on nanoparticle tumor delivery.
Tavares AJ, et al. Proc Natl Acad Sci U S A 2017. PMID 29208719 Free PMC article.
This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered by nontumor cells. ...Here, we hypothesize that the removal of the liver macrophages, cells that have been reported to take up the largest amount of circulating nanoparticles, would lead to a significant increase in the nanoparticle delivery efficiency to solid tumors. ...
This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered …
Role of Kupffer cells in storage and metabolism of benzo(a)pyrene in the liver.
Zhong Z, et al. Drug Metab Dispos 1994. PMID 7835217
This study investigates the possible role of Kupffer cells in storage and metabolism of benzo(a)pyrene in the liver. In perfused liver, benzo(a)pyrene (4-120 microM) in 0.3% albumin increased fluorescence (366-->405 mm) on the liver surface in a dose-dependent manner, suggesting that it accumulated in liver tissue. ...Moreover, yellow-green fluorescent particles were detected in cultured Kupffer cells, but were barely visible in parenchymal and Ito cells, indicating that Kupffer cells actively accumulated benzo(a)pyrene. ...
This study investigates the possible role of Kupffer cells in storage and metabolism of benzo(a)pyrene in the liver. In …
Metabolism of 4-hydroxynonenal by rat Kupffer cells.
Luckey SW and Petersen DR. Arch Biochem Biophys 2001. PMID 11370675
The cytotoxicity of 4-HNE on Kupffer cells was assessed and the TD50 value of 32.5+/-2.2 microM for 4-HNE was determined. HPLC measurement of 4-HNE metabolism using suspensions of Kupffer cells incubated with 25 microLM 4-HNE indicated a loss of 4-HNE over the 30-min time period. ...These data demonstrate that oxidative and conjugative pathways are primarily responsible for the metabolism of 4-HNE in Kupffer cells. ...
The cytotoxicity of 4-HNE on Kupffer cells was assessed and the TD50 value of 32.5+/-2.2 microM for 4-HNE was determined. HPLC …
RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis
Han YH, et al. Cell Rep 2017. PMID 28683306 Free article.
Here, we describe the orphan nuclear receptor retinoic-acid-related orphan receptor α (RORα) as a key regulator of M1/M2 polarization in hepatic residential Kupffer cells (KCs) and infiltrated monocyte-derived macrophages. ...
Here, we describe the orphan nuclear receptor retinoic-acid-related orphan receptor α (RORα) as a key regulator of M1/M2 polarization in hep …
An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.
Park JK, et al. Hepatology 2017. PMID 28090670 Free PMC article.
Nogo-B in Kupffer cells promoted M1 polarization, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupffer cells. ...Nogo-B in Kupffer cells may represent a new therapeutic target for ALD. (Hepatology 2017;65:1720-1734)....
Nogo-B in Kupffer cells promoted M1 polarization, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupf
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