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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1972 1
1973 1
1974 5
1975 6
1976 3
1977 8
1978 9
1979 5
1980 4
1981 3
1982 7
1983 8
1984 7
1985 11
1986 10
1987 14
1988 4
1989 6
1990 10
1991 9
1992 18
1993 15
1994 18
1995 23
1996 21
1997 16
1998 17
1999 27
2000 22
2001 20
2002 34
2003 32
2004 20
2005 36
2006 39
2007 32
2008 31
2009 24
2010 24
2011 33
2012 35
2013 39
2014 26
2015 33
2016 41
2017 30
2018 44
2019 7
2020 0
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828 results
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Page 1
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury.
Sato K, et al. Am J Pathol 2016 - Review. PMID 27452297 Free PMC article.
Activated Kupffer cells secrete various mediators, including cytokines and chemokines, to initiate immune responses, inflammation, or recruitment of other liver cells. ...Various mediators produced by other liver cells can regulate Kupffer cell activation, which suggest that Kupffer cells orchestrate with other liver cells to relay inflammatory signals and to maintain liver homeostasis during BDL-induced liver injury. ...
Activated Kupffer cells secrete various mediators, including cytokines and chemokines, to initiate immune responses, inflammat …
The role of Kupffer cells in hepatic diseases.
Li P, et al. Mol Immunol 2017 - Review. PMID 28314211
Kupffer cells (KCs) constitute 80-90% of the tissue macrophages present in the body. Essential to innate and adaptive immunity, KCs are responsible for the swift containment and clearance of exogenous particulates and immunoreactive materials which are perceived as foreign and harmful to the body. ...A better understanding of KCs biological characteristics and immunologic function in liver homeostasis and pathology may pave the way to investigate new diagnostic and therapeutic approaches for hepatic diseases....
Kupffer cells (KCs) constitute 80-90% of the tissue macrophages present in the body. Essential to innate and adaptive immunity
Importance of Kupffer cells in the development of acute liver injuries in mice.
Tsutsui H and Nishiguchi S. Int J Mol Sci 2014 - Review. PMID 24802875 Free PMC article.
Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupffer cells. ...Kupffer cells contribute to Con A-induced acute liver failure by initiating pathogenic, intrasinusoidal thrombosis in collaboration with sinusoidal endothelial cells. ...
Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupf
Macrophages in the Aging Liver and Age-Related Liver Disease
Stahl EC, et al. Front Immunol 2018 - Review. PMID 30555477 Free PMC article.
Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicated in several chronic liver diseases and also play important roles in the homeostatic functions of the liver. ...
Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicate …
Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy.
Jemail L, et al. Sci Rep 2018. PMID 29686325 Free PMC article.
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown. ...Moreover, KCs were associated with abnormal phenotypic changes in other liver cells, such as hepatocytes, biliary epithelial cells, liver sinusoidal endothelial cells, and hepatic stellate cells. ...
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the
Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease.
Wenfeng Z, et al. Ann Hepatol 2014 - Review. PMID 25152980 Free article.
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) pathways as a result of lipopolysaccharide (LPS) recognition by Toll-like receptor 4 (TLR4). ...
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in …
Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease.
Luo W, et al. Sci Rep 2017. PMID 28300213 Free PMC article.
Here we showed that long-term high-fat diet increased Kupffer cells content with M1-predominant phenotype and increasing production of pro-inflammatory cytokines. Saturated fatty acids polarized Kupffer cells/macrophages to an M1-predominant phenotype while n-3 PUFA polarized Kupffer cells/macrophages to an M2 phenotype, which was associated with activation of NF-κB signal pathway and PPAR-γ respectively. ...
Here we showed that long-term high-fat diet increased Kupffer cells content with M1-predominant phenotype and increasing produ …
Liver macrophages in healthy and diseased liver
Abdullah Z and Knolle PA. Pflugers Arch 2017 - Review. PMID 28293730
These important roles of Kupffer cells were recently identified in healthy and diseased liver revealing diverse functions and phenotypes of hepatic macrophages. High-level phenotypic and genomic analysis revealed that Kupffer cells are not a homogenous population and that the hepatic microenvironment actively shapes both phenotype and function of liver macrophages. ...
These important roles of Kupffer cells were recently identified in healthy and diseased liver revealing diverse functions and …
Mesenchymal stem cells attenuate sepsis-induced liver injury via inhibiting M1 polarization of Kupffer cells.
Liang X, et al. Mol Cell Biochem 2019. PMID 30178273
Inflammatory cytokines, Kupffer cell M1 phenotype markers, and associated signal molecules were also determined in septic rats and in lipopolysaccharide (LPS)-treated Kupffer cells. ...Treatment with MSCs inhibited activation of Kupffer cells towards M1 phenotype, attenuated TNF-α and IL-6 expression, and promoted IL-4 and IL-10 expression in septic rats and LPS-treated Kupffer cells. ...
Inflammatory cytokines, Kupffer cell M1 phenotype markers, and associated signal molecules were also determined in septic rats and in …
The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration.
Tan Q, et al. Biomed Res Int 2016 - Review. PMID 27092311 Free PMC article.
Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells....
Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic
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