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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 3
1973 7
1974 8
1975 14
1976 16
1977 15
1978 19
1979 10
1980 17
1981 20
1982 20
1983 17
1984 25
1985 36
1986 22
1987 25
1988 48
1989 45
1990 56
1991 71
1992 52
1993 55
1994 74
1995 68
1996 65
1997 60
1998 41
1999 64
2000 57
2001 59
2002 68
2003 60
2004 48
2005 51
2006 46
2007 50
2008 39
2009 37
2010 42
2011 43
2012 59
2013 58
2014 53
2015 44
2016 55
2017 53
2018 54
2019 19
2020 0
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1,890 results
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Page 1
Kupffer cells in the liver.
Dixon LJ, et al. Compr Physiol 2013 - Review. PMID 23720329 Free PMC article.
Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair. Kupffer cells exhibit a tremendous plasticity; depending on the local metabolic and immune environment, then can express a range of polarized phenotypes, from the proinflammatory M1 phenotype to the alternative/M2 phenotype. ...
Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic r
Role of Kupffer cells in host defense and liver disease.
Bilzer M, et al. Liver Int 2006 - Review. PMID 17105582
Kupffer cells (KC) constitute 80-90% of the tissue macrophages present in the body. They reside within the lumen of the liver sinusoids, and are therefore constantly exposed to gut-derived bacteria, microbial debris and bacterial endotoxins, known to activate macrophages. ...These factors regulate the phenotype of KC themselves, and the phenotypes of neighboring cells, such as hepatocytes, stellate cells, endothelial cells and other immune cells that traffic through the liver. ...
Kupffer cells (KC) constitute 80-90% of the tissue macrophages present in the body. They reside within the lumen of the liver
Macrophages in the Aging Liver and Age-Related Liver Disease
Stahl EC, et al. Front Immunol 2018 - Review. PMID 30555477 Free PMC article.
Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicated in several chronic liver diseases and also play important roles in the homeostatic functions of the liver. ...
Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicate …
Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease.
Wenfeng Z, et al. Ann Hepatol 2014 - Review. PMID 25152980 Free article.
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) pathways as a result of lipopolysaccharide (LPS) recognition by Toll-like receptor 4 (TLR4). ...
Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in …
Effect of removing Kupffer cells on nanoparticle tumor delivery.
Tavares AJ, et al. Proc Natl Acad Sci U S A 2017. PMID 29208719 Free PMC article.
This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered by nontumor cells. ...Here, we hypothesize that the removal of the liver macrophages, cells that have been reported to take up the largest amount of circulating nanoparticles, would lead to a significant increase in the nanoparticle delivery efficiency to solid tumors. ...
This low delivery efficiency has major implications in the translation of cancer nanomedicines, as most of the nanomedicines are sequestered …
M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease.
Wan J, et al. Hepatology 2014. PMID 23832548
We have shown that limiting classical (M1) Kupffer cell (KC) polarization reduces alcohol-induced liver injury. Herein, we investigated whether favoring alternatively activated M2 KCs may protect against ALD and NAFLD. ...Mechanistically, IL10 released from M2 cells promoted M1 death, and anti-IL10 antibodies blunted the proapoptic effects of M2-conditioned media. ...
We have shown that limiting classical (M1) Kupffer cell (KC) polarization reduces alcohol-induced liver injury. Herein, we investigat …
Regulation of Hepatic Inflammation via Macrophage Cell Death
Li Z and Weinman SA. Semin Liver Dis 2018 - Review. PMID 30357771
Liver macrophages consist of both resident Kupffer cells and infiltrating macrophages. They have heterogeneous highly plastic phenotypes, and they change their phenotypes rapidly in response to a diverse array of signals present in the injured or recovering liver. ...At the same time, the uptake of apoptotic and other dead cells, efferocytosis, is mediated by a series of dead cell receptors including MerTK, TIM4, and Stablin-1. ...
Liver macrophages consist of both resident Kupffer cells and infiltrating macrophages. They have heterogeneous highly plastic …
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Sakai M, et al. Immunity 2019. PMID 31587991 Free PMC article.
We obtained evidence that combinatorial interactions of the Notch ligand DLL4 and transforming growth factor-b (TGF-β) family ligands produced by sinusoidal endothelial cells and endogenous LXR ligands were required for the induction and maintenance of Kupffer cell identity. ...These factors in turn reprogrammed the repopulating liver macrophage enhancer landscape to converge on that of the original resident Kupffer cells. ...
We obtained evidence that combinatorial interactions of the Notch ligand DLL4 and transforming growth factor-b (TGF-β) family ligands produc …
An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization.
Park JK, et al. Hepatology 2017. PMID 28090670 Free PMC article.
Nogo-B in Kupffer cells promoted M1 polarization, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupffer cells. ...Nogo-B in Kupffer cells may represent a new therapeutic target for ALD. (Hepatology 2017;65:1720-1734)....
Nogo-B in Kupffer cells promoted M1 polarization, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupf
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