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1813 1
1814 1
1815 2
1818 1
1820 1
1823 1
1825 1
1827 4
1828 2
1829 2
1830 3
1831 1
1834 2
1841 2
1842 3
1843 3
1844 5
1845 1
1846 4
1847 2
1848 2
1849 2
1850 5
1851 3
1852 4
1853 8
1854 5
1855 7
1856 4
1857 10
1858 5
1859 4
1860 3
1861 6
1862 5
1863 3
1864 5
1865 3
1866 1
1867 6
1868 7
1869 4
1870 5
1871 2
1872 8
1873 3
1874 5
1875 3
1876 6
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1879 10
1880 11
1881 3
1882 5
1883 1
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1886 8
1887 5
1888 6
1889 7
1890 4
1891 5
1892 10
1893 12
1894 9
1895 6
1896 2
1897 3
1898 6
1899 5
1900 5
1901 6
1902 3
1903 5
1904 3
1905 4
1906 9
1907 4
1908 6
1909 2
1910 12
1911 4
1912 2
1913 3
1914 2
1915 3
1916 1
1918 2
1919 1
1920 5
1921 8
1922 3
1923 6
1924 4
1925 6
1926 6
1927 11
1928 8
1929 5
1930 8
1931 4
1932 4
1933 7
1934 5
1935 8
1936 6
1937 7
1938 6
1939 7
1940 8
1941 10
1942 8
1943 2
1944 2
1945 46
1946 148
1947 222
1948 205
1949 195
1950 348
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Page 1
Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update.
Patsalos PN, Spencer EP, Berry DJ. Patsalos PN, et al. Ther Drug Monit. 2018 Oct;40(5):526-548. doi: 10.1097/FTD.0000000000000546. Ther Drug Monit. 2018. PMID: 29957667 Review.
BACKGROUND: Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Since 1989, 18 new AEDs have been licensed for clinical use and there are now 27 licensed AEDs in total for the treatment of patients with epilepsy. Furthermore, several AEDs are also use …
BACKGROUND: Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Since 1989, 18 new AEDs have been licensed for clinica …
Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs.
Zaccara G, Perucca E. Zaccara G, et al. Epileptic Disord. 2014 Dec;16(4):409-31. doi: 10.1684/epd.2014.0714. Epileptic Disord. 2014. PMID: 25515681 Free article. Review.
Examples of important interactions mediated by enzyme inhibition include the increase in the serum concentration of phenobarbital and lamotrigine caused by valproic acid. There are also interactions whereby other drugs induce or inhibit the metabolism of antiepileptic drug …
Examples of important interactions mediated by enzyme inhibition include the increase in the serum concentration of phenobarbital and lam …
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Nevitt SJ, Sudell M, Cividini S, Marson AG, Tudur Smith C. Nevitt SJ, et al. Cochrane Database Syst Rev. 2022 Apr 1;4(4):CD011412. doi: 10.1002/14651858.CD011412.pub4. Cochrane Database Syst Rev. 2022. PMID: 35363878 Free PMC article.
BACKGROUND: This is an updated version of the original Cochrane Review published in 2017. Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from …
BACKGROUND: This is an updated version of the original Cochrane Review published in 2017. Epilepsy is a common neurological condition …
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Kaplan YC, Demir O. Kaplan YC, et al. Curr Neuropharmacol. 2021;19(11):1805-1824. doi: 10.2174/1570159X19666210211150856. Curr Neuropharmacol. 2021. PMID: 33573557 Free PMC article. Review.
This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy. ...
This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenoba …
Drugs for epilepsy.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2024 Aug 5;66(1708):121-128. doi: 10.58347/tml.2024.1708a. Med Lett Drugs Ther. 2024. PMID: 39073880 No abstract available.
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F; EURAP Study Group. Tomson T, et al. Lancet Neurol. 2018 Jun;17(6):530-538. doi: 10.1016/S1474-4422(18)30107-8. Epub 2018 Apr 18. Lancet Neurol. 2018. PMID: 29680205 Free article.
The primary objective was to compare the risk of major congenital malformations assessed at 1 year after birth in offspring exposed prenatally to one of eight commonly used antiepileptic drugs (carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phe …
The primary objective was to compare the risk of major congenital malformations assessed at 1 year after birth in offspring exposed prenatal …
Antiepileptic drug mechanisms of action.
Macdonald RL, Kelly KM. Macdonald RL, et al. Epilepsia. 1995;36 Suppl 2:S2-12. doi: 10.1111/j.1528-1157.1995.tb05996.x. Epilepsia. 1995. PMID: 8784210 Free article. Review.
Benzodiazepines and barbiturates enhance GABAA receptor-mediated inhibition. Phenytoin (PHT), carbamazepine (CBZ), and possibly valproate (VPA) decrease high-frequency repetitive firing of action potentials by enhancing sodium-channel inactivation. ...This binding site may …
Benzodiazepines and barbiturates enhance GABAA receptor-mediated inhibition. Phenytoin (PHT), carbamazepine (CBZ), and possibly valpr …
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force.
Tomson T, Battino D, Bromley R, Kochen S, Meador KJ, Pennell PB, Thomas SV. Tomson T, et al. Epileptic Disord. 2022 Dec 1;24(6):1020-1032. doi: 10.1684/epd.2022.1492. Epileptic Disord. 2022. PMID: 36193017 Free article. English.
For ASMs, with available information on levels in breastfed infants, very low concentrations (in the order of 10% or less of maternal serum concentrations) were reported for carbamazepine, gabapentin, levetiracetam, oxcarbazepine, phenytoin, valproate, and clonazepam. Slig …
For ASMs, with available information on levels in breastfed infants, very low concentrations (in the order of 10% or less of maternal serum …
Epilepsy (partial).
Maguire M, Marson AG, Ramaratnam S. Maguire M, et al. BMJ Clin Evid. 2011 May 6;2011:1214. BMJ Clin Evid. 2011. PMID: 21549021 Free PMC article.
INTRODUCTION: About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy eventually go into remission. ...CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of t …
INTRODUCTION: About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy …
Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis.
Milosavljevic F, Manojlovic M, Matkovic L, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM. Milosavljevic F, et al. JAMA Netw Open. 2024 Aug 1;7(8):e2425593. doi: 10.1001/jamanetworkopen.2024.25593. JAMA Netw Open. 2024. PMID: 39115847 Free PMC article.
RESULTS: Data from 98 studies involving 12 543 adult participants treated with phenytoin, valproate, lamotrigine, or carbamazepine were analyzed. Studies were mainly conducted within East Asian (69 studies) or White or European (15 studies) cohorts. Significant incr …
RESULTS: Data from 98 studies involving 12 543 adult participants treated with phenytoin, valproate, lamotrigine, or carbamaze …
265,657 results
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