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Year Number of Results
1954 2
1955 7
1956 22
1957 35
1958 27
1959 18
1964 1
1965 10
1966 118
1967 207
1968 222
1969 212
1970 261
1971 338
1972 349
1973 396
1974 443
1975 452
1976 456
1977 420
1978 476
1979 534
1980 480
1981 523
1982 630
1983 545
1984 574
1985 606
1986 641
1987 611
1988 745
1989 729
1990 832
1991 823
1992 813
1993 855
1994 885
1995 880
1996 883
1997 992
1998 989
1999 1031
2000 1002
2001 1000
2002 1171
2003 1208
2004 1427
2005 1556
2006 1785
2007 2003
2008 2196
2009 2100
2010 2033
2011 2332
2012 2532
2013 2576
2014 2509
2015 2505
2016 2516
2017 2370
2018 2176
2019 864
2020 10
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51,887 results
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Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning.
Uhernik AL, et al. Neurobiol Learn Mem 2018. PMID 29432803
Therefore, we designed a study to investigate effects of CBD on fear learning and memory when administered to mice prior to administering a trace fear conditioning protocol which imposes cognitive demands on the learning and memory process. ...Overall, the memory-modulating effects of a single pre-conditioning dose of CBD, which we show here, demonstrate the need to more fully characterize its basic effects on memory, suggest caution when using it clinically as an anxiolytic, and point to a need for more research into its potential as a therapeutic for treating memory-loss disorders....
Therefore, we designed a study to investigate effects of CBD on fear learning and memory when administered to mice prior to ad …
Behavioral methods for measuring effects of drugs on learning and memory in animals.
Heise GA. Med Res Rev 1984 - Review. PMID 6387332
Procedures for separating drug effects specific to learning and memory from non-specific effects on activity, motivation, sensory and motor capacity, etc., were emphasized. ...How, then, should drug effects on learning and memory be identified or measured? The first step, of course, is to rule out those drug effects that do not conform to the definition of learning or memory. ...
Procedures for separating drug effects specific to learning and memory from non-specific effects on activity, mo …
Conditioned Taste Avoidance Drug Discrimination Procedure: Assessments and Applications.
Riley AL, et al. Curr Top Behav Neurosci 2018 - Review. PMID 27221624
Importantly, much remains to be learned about the taste avoidance procedure in that the nature of such learning remains unknown and the specific parameters under which it can be established and generalized and its neurochemical and neuroanatomical bases are largely unexplored. The application of drug discrimination learning to human drug abuse continues to be an important consideration for this specific design (as well as that of drug discrimination procedures in general), and recent parallels between drug use and food intake in terms of its regulation by interoceptive stimuli suggests a possible role of the loss of stimulus control in drug escalation and addiction (with possible therapeutic implications via the modulation of these interoceptive cues)....
Importantly, much remains to be learned about the taste avoidance procedure in that the nature of such learning remains unknown and t …
Applications and limitations of behaviorally conditioned immunopharmacological responses
Lückemann L, et al. Neurobiol Learn Mem 2017 - Review. PMID 28216206
One possible application for placebo responses in pharmacotherapy is given by learning paradigms, such as behaviorally conditioned immunosuppression, aiming at drug dose reduction while maintaining therapeutic efficacy of drug treatment. In an established learning paradigm of conditioned taste aversion/avoidance (CTA) in both, rats and humans, respectively, a novel-tasting drinking solution (conditioned stimulus, CS) is paired with an injection of the immunosuppressive drug cyclosporine A (CsA) as unconditioned stimulus (US). ...
One possible application for placebo responses in pharmacotherapy is given by learning paradigms, such as behaviorally conditioned im …
Effects of sodium barbitone on learning and memory-storage of an appetitive and an aversive task.
Tomaz CA, et al. Pharmacol Biochem Behav 1982. PMID 7178204
Learning was observed in both situations, with acquisition unimpaired by the drug. Sodium barbitone did, however, affect retention of both tasks in all groups treated with the drug before training. Results are discussed in light of the various modes of action of this drug, i.e., as an inhibitor of protein synthesis, as a blocker of catecholamine biosynthesis, with regard to its effects on paradoxical sleep and on gamma-amino-butyric acid (GABA)....
Learning was observed in both situations, with acquisition unimpaired by the drug. Sodium barbitone did, however, affect reten
Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images
Weafer J, et al. Alcohol Clin Exp Res 2016 - Clinical Trial. PMID 27219099 Free PMC article.
BACKGROUND: Drug and alcohol abusers develop strong memories for drug-related stimuli. Preclinical studies suggest that such memories are a result of drug actions on reward pathways, which facilitate learning about drug-related stimuli. ...Memory retrieval was tested exactly 48 hours later, in a drug-free state. RESULTS: Alcohol impaired memory in the encoding condition and enhanced memory in the consolidation condition, but these effects did not differ for alcohol-related and neutral beverage stimuli. ...
BACKGROUND: Drug and alcohol abusers develop strong memories for drug-related stimuli. Preclinical studies suggest that such m …
Early memory consolidation window enables drug induced state-dependent memory.
Osorio-Gómez D, et al. Neuropharmacology 2019. PMID 30485798
It is well established that newly acquired information is stabilized over time by processes underlying memory consolidation, these events can be impaired by many drug treatments administered shortly after learning. ...The present experiments investigated the effects of amnesic drugs infused into the insular cortex of male Wistar rats on memory for object recognition training. ...
It is well established that newly acquired information is stabilized over time by processes underlying memory consolidation, these events ca …
Effects of lobeline, a nicotinic receptor agonist, on learning and memory.
Decker MW, et al. Pharmacol Biochem Behav 1993. PMID 8332618
The effects of (-)-lobeline were assessed in two learning and memory tasks in which nicotine-induced enhancement of performance has previously been demonstrated. ...These findings suggest that lobeline's effects on the performance of learning and memory tasks may be similar to those of nicotine. ...
The effects of (-)-lobeline were assessed in two learning and memory tasks in which nicotine-induced enhancement of performanc …
Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice.
Gómez MC, et al. Behav Processes 2016. PMID 26688488
Bupropion is an antidepressant drug that is known to aid smoking cessation, although little experimental evidence exists about its actions on active avoidance learning tasks. Our aim was to evaluate the effects of this drug on two-way active avoidance conditioning. In this study, NMRI mice received bupropion (10, 20 and 40mg/kg) or saline before a daily training session (learning phase, days 1-4) in the active avoidance task. ...
Bupropion is an antidepressant drug that is known to aid smoking cessation, although little experimental evidence exists about its ac …
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