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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 1
1993 1
1995 40
1996 232
1997 461
1998 646
1999 753
2000 911
2001 958
2002 1004
2003 1076
2004 1117
2005 1228
2006 1317
2007 1320
2008 1431
2009 1390
2010 1466
2011 1405
2012 1351
2013 1456
2014 1484
2015 1377
2016 1164
2017 1097
2018 938
2019 403
2020 2
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23,164 results
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Page 1
The Leptin Resistance.
Liu J, et al. Adv Exp Med Biol 2018 - Review. PMID 30390289
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. Leptin resistance is defined by a reduced sensitivity or a failure in response of the brain to leptin, showing a decrease in the ability of leptin to suppress appetite or enhance energy expenditure, which causes an increased food intake and finally leads to overweight, obesity, cardiovascular diseases, and other metabolic disorders. Leptin resistance is a challenge for clinical treatment or drug discovery of obesity. Until recently, emerging evidence has been showing novel mechanisms of the leptin resistance. ...
The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. …
Leptin resensitisation: a reversion of leptin-resistant states.
Andreoli MF, et al. J Endocrinol 2019 - Review. PMID 30959481
Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. ...Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. ...
Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperl
Signaling Pathways Induced by Leptin during Epithelial⁻Mesenchymal Transition in Breast Cancer.
Olea-Flores M, et al. Int J Mol Sci 2018 - Review. PMID 30404206 Free PMC article.
Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. ...In this review, we focus on recent advances that establish: (1) leptin as a risk factor for the development of breast cancer, and (2) leptin as an inducer of EMT, an event that promotes tumor progression....
Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high lev
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity.
Dallner OS, et al. Nat Med 2019. PMID 30842678
Diet-induced obese mice lacking lncOb show increased fat mass with reduced plasma leptin levels and lose weight after leptin treatment, whereas control mice do not. ...These results show that reduced leptin gene expression can lead to a hypoleptinemic, leptin-responsive form of obesity and provide a framework for elucidating the pathogenic mechanism in the subset of obese patients with low endogenous leptin levels....
Diet-induced obese mice lacking lncOb show increased fat mass with reduced plasma leptin levels and lose weight after leptin t …
Leptin as a breast milk component for the prevention of obesity.
Palou M, et al. Nutr Rev 2018 - Review. PMID 30285146
Leptin ingested as a component of breast milk is increasingly recognized to play a role in the postnatal programming of a healthy phenotype in adulthood. ...This review delves into the following topics: (1) the imprinted protective function of adequate leptin intake during lactation in future metabolic health; (2) the consequences of a lack of leptin intake or of alterations in leptin levels; and (3) the mechanisms described for the effects of leptin on postnatal programming. ...
Leptin ingested as a component of breast milk is increasingly recognized to play a role in the postnatal programming of a healthy phe
Leptin Functions in Infectious Diseases.
Maurya R, et al. Front Immunol 2018 - Review. PMID 30534129 Free PMC article.
Leptin is secreted by adipose tissue and encoded by the obese (ob) gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Importantly, leptin can modulate both innate and adaptive immune responses. Leptin deficiency/resistance is associated with dysregulation of cytokine production, increased susceptibility toward infectious diseases, autoimmune disorders, malnutrition and inflammatory responses. ...
Leptin is secreted by adipose tissue and encoded by the obese (ob) gene. Leptin acts as a central mediator which regulates imm
Leptin in depression: a potential therapeutic target.
Ge T, et al. Cell Death Dis 2018 - Review. PMID 30367065 Free PMC article.
Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating body weight, food intake, and energy metabolism. ...It is also well documented that leptin has effects on neural plasticity. This review summarizes the recent literature on the role of leptin in neural plasticity in order to elaborate the possible mechanism of leptin's antidepressant-like effects. ...
Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating body weight, food intake, and energy metab
Leptin receptor is expressed by tissue mast cells.
Żelechowska P, et al. Immunol Res 2018. PMID 30269202 Free PMC article.
It has also been established that leptin regulates immune and inflammatory processes. All leptin-induced biological activities depend on binding to the membrane-spanning leptin receptor (Ob-R), belonging to the class I cytokine receptor family. ...Additionally, leptin influences its receptor expression on these cells. Leptin at lower concentrations caused Ob-R expression increase both at the cell surface and in the cell interior. ...
It has also been established that leptin regulates immune and inflammatory processes. All leptin-induced biological activities …
Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis.
Hackl MT, et al. Nat Commun 2019. PMID 31222048 Free PMC article.
Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin reverses steatosis of hypoleptinemic patients with lipodystrophy by an unknown mechanism. Since leptin mainly functions via CNS signaling, we here examine in rats whether leptin regulates hepatic lipid flux via the brain in a series of stereotaxic infusion experiments. ...
Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighte …
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