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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1948 1
1949 5
1950 17
1951 29
1952 21
1953 16
1954 15
1955 17
1956 23
1957 25
1958 27
1959 34
1960 31
1961 28
1962 34
1963 113
1964 185
1965 161
1966 174
1967 180
1968 235
1969 333
1970 291
1971 330
1972 341
1973 327
1974 393
1975 349
1976 294
1977 314
1978 303
1979 349
1980 335
1981 307
1982 345
1983 366
1984 404
1985 451
1986 420
1987 425
1988 411
1989 468
1990 561
1991 477
1992 521
1993 535
1994 542
1995 506
1996 537
1997 528
1998 581
1999 560
2000 562
2001 494
2002 499
2003 499
2004 536
2005 511
2006 576
2007 588
2008 608
2009 641
2010 600
2011 565
2012 648
2013 600
2014 597
2015 511
2016 579
2017 541
2018 514
2019 271
2020 11
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24,188 results
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Page 1
Perioperative Use of Intravenous Lidocaine.
Beaussier M, et al. Drugs 2018 - Review. PMID 30117019
Lidocaine is an amide local anaesthetic initially used intravenously as an antiarrhythmic agent. At some point it was proposed that intravenous lidocaine (IVL) had an analgesic effect that could be potentially beneficial in perioperative settings. ...The purpose of this review is to address the pharmacokinetic and pharmacodynamic properties of lidocaine in healthy and pathological conditions....
Lidocaine is an amide local anaesthetic initially used intravenously as an antiarrhythmic agent. At some point it was proposed that i
Intravenous lidocaine.
Estebe JP. Best Pract Res Clin Anaesthesiol 2017 - Review. PMID 29739540
Lidocaine has analgesic effect and antihyperalgesic and anti-inflammatory properties, which enable its use as a general anesthetic adjuvant. ...By using the recommended protocols, a high safety and efficacy of lidocaine can be achieved....
Lidocaine has analgesic effect and antihyperalgesic and anti-inflammatory properties, which enable its use as a general anesthetic ad
Intravenous Lidocaine for Acute Pain: A Systematic Review.
Masic D, et al. Pharmacotherapy 2018. PMID 30303542
This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients. ...Larger, prospective studies are needed before the routine use of IV lidocaine can be recommended for all types of acute pain....
This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patie …
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults.
Weibel S, et al. Cochrane Database Syst Rev 2018 - Review. PMID 29864216 Free PMC article.
The non-opioid, lidocaine, was investigated in several studies for its use in multimodal management strategies to reduce postoperative pain and enhance recovery. ...The IV lidocaine infusion must have been started intraoperatively, prior to incision, and continued at least until the end of surgery. ...
The non-opioid, lidocaine, was investigated in several studies for its use in multimodal management strategies to reduce postoperativ …
New local anesthetics
Shah J, et al. Best Pract Res Clin Anaesthesiol 2018 - Review. PMID 30322458
Older medications such as lidocaine and bupivacaine as well as newer ones such as mepivacaine and ropivacaine are being used successfully for decades. ...
Older medications such as lidocaine and bupivacaine as well as newer ones such as mepivacaine and ropivacaine are being used successf …
Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety.
Bailey M, et al. Pain 2018. PMID 29757886
Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP. ...Trials that randomized adults without baseline pain to perioperative lidocaine infusion or placebo were included if they reported on CPSP. ...
Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify a …
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study.
Forster C, et al. Br J Anaesth 2018 - Clinical Trial. PMID 30336850 Free article.
Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i.v. lidocaine reduces propofol requirements during colonoscopy and improves post-colonoscopy recovery. ...Post-colonoscopy pain (P<0.01) and fatigue (P=0.03) were significantly lower in the lidocaine group. CONCLUSIONS: Intravenous infusion of lidocaine resulted in a 50% reduction in propofol dose requirements during colonoscopy. ...
Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i. …
Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration.
D'Agostino G, et al. Br J Anaesth 2018. PMID 30236259 Free article.
The effect of lidocaine was not associated with modulation of the CD44 adhesion molecule. CONCLUSIONS: At clinical concentrations, lidocaine significantly inhibits CXCR4 signalling. The results presented shed new insights on the molecular mechanisms governing the inhibitory effect of lidocaine on cell migration....
The effect of lidocaine was not associated with modulation of the CD44 adhesion molecule. CONCLUSIONS: At clinical concentrations, …
Effects of Lidocaine and Articaine on Neuronal Survival and Recovery.
Albalawi F, et al. Anesth Prog 2018. PMID 29952644 Free PMC article.
Articaine had no effect on the survival of SH-SY5Y cells, while lidocaine produced a significant reduction only when used as pure powder. ...In conclusion, articaine does not damage neural cells more than lidocaine in this in vitro model. While this does not question the safety of lidocaine used clinically, it does suggest that articaine is no more neurotoxic, at least in the in vitro setting....
Articaine had no effect on the survival of SH-SY5Y cells, while lidocaine produced a significant reduction only when used as pure pow …
Intranasal Lidocaine for Acute Management of Primary Headaches: A Systematic Review.
Dagenais R and Zed PJ. Pharmacotherapy 2018. PMID 30098024
Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this systematic review was to evaluate the efficacy and safety of intranasal lidocaine in the acute management of primary headaches. ...Studies conducted in patients with acute primary headache were included if lidocaine was compared with placebo or alternative treatments, lidocaine dosing was specified, and patients' pain before and after treatment were clearly reported. ...
Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this sy …
24,188 results
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