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Year Number of Results
1979 1
1980 2
1981 1
1985 3
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1987 5
1988 6
1989 10
1990 18
1991 20
1992 20
1993 20
1994 25
1995 22
1996 30
1997 31
1998 34
1999 32
2000 26
2001 29
2002 27
2003 41
2004 44
2005 56
2006 46
2007 50
2008 69
2009 75
2010 90
2011 98
2012 113
2013 109
2014 118
2015 140
2016 87
2017 94
2018 86
2019 34
2020 0
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Smagris E, et al. Hepatology 2016. PMID 26099489
The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Johansson BB, et al. Pancreatology 2018 - Review. PMID 29233499
The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or -stimulated lipase (BSDL, BSSL), hydrolyzes dietary fat, cholesteryl esters and fat-soluble vitamins in the duodenum. ...
The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or -stimulated lipase (BSDL, BSSL), hydrolyzes dieta …
Site-directed mutagenesis: role of lid region for T1 lipase specificity.
Mohamed RA, et al. Protein Eng Des Sel 2018. PMID 30239965
BSLA lipase was chosen as the reference protein for T1 lipase modification since it contains no lid. Initially, structures of both enzymes were compared via protein-protein superimposition in 3D-space and the location of the lid region of T1 lipase was highlighted. A total of three variants of T1 lipase without lid were successfully designed by referring to BSLA lipase (a lipase without lid). ...
BSLA lipase was chosen as the reference protein for T1 lipase modification since it contains no lid. Initially, structures of …
Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables.
Vespasiani-Gentilucci U, et al. World J Gastroenterol 2018. PMID 30487694 Free PMC article.
Therefore, risk stratification emerges as fundamental in order to optimize human and economic resources, and genetics displays intrinsic characteristics suitable to fulfill this task. ...However, to date, clinical translation of genetics in the field of NAFLD has been poor or absent. Fortunately, the research we have done seems to have placed us on the right path: We should rely on longitudinal rather than on cross-sectional studies; we should focus on relevant outcomes rather than on simple liver fat accumulation; and we should put together the genetic and clinical information. ...
Therefore, risk stratification emerges as fundamental in order to optimize human and economic resources, and genetics displays intrin …
Molecular characterization and bioinformatics studies of a lipase from Bacillus thermoamylovorans BHK67.
Sharma A, et al. Int J Biol Macromol 2018. PMID 29051101
The lipase was purified to homogeneity by anion exchange chromatography with 15-fold purification and 12.1% yield. The lipase appeared to be a hexameric protein as it possessed a single band of Mr 25kDa in SDS PAGE and 150kDa in Native PAGE. ...The purified lipase showed maximum activity at pH 7.5 with a half-life of 10.5h at 55°C. Kinetic study of purified lipase by Lineweaver-Burk plot provided K(m) (7.7mM),V(max) (90.9U/mL/min),K(cat) (227.3s(-1)) and K(spec) (29.4mMs(-1)) for substrate p-nitrophenylpalmitate.The purified lipase also showed astonishing stability following exposure to ethanol, n-propanol, iso-propanol, n-butanol and DMSO. ...
The lipase was purified to homogeneity by anion exchange chromatography with 15-fold purification and 12.1% yield. The lipase
High-level expression and characterization of solvent-tolerant lipase.
Wang Y, et al. J Biosci Bioeng 2018. PMID 28743658
In this study, the coding sequence of the lipase from Proteus sp. SW1 was optimized via codon optimization and subjected to expression in Pichia pastoris GS115. ...The purified recombinant lipase exhibited a specific activity of 130 U/mg toward p-nitrophenyl Laurate. Its optimum pH and temperature were 8.0 and 40°C, respectively. ...
In this study, the coding sequence of the lipase from Proteus sp. SW1 was optimized via codon optimization and subjected to expressio …
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