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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1943 1
1945 140
1946 397
1947 543
1948 630
1949 661
1950 1040
1951 892
1952 960
1953 1188
1954 1140
1955 1239
1956 1299
1957 1368
1958 1338
1959 1494
1960 1407
1961 1494
1962 1703
1963 2670
1964 3773
1965 2840
1966 2499
1967 2689
1968 3067
1969 3071
1970 2662
1971 2900
1972 3343
1973 3221
1974 3397
1975 3315
1976 3438
1977 3419
1978 3673
1979 3803
1980 3980
1981 4078
1982 4043
1983 4197
1984 4332
1985 4169
1986 4084
1987 4301
1988 4350
1989 4450
1990 4624
1991 4572
1992 4380
1993 4479
1994 4383
1995 4407
1996 4235
1997 4211
1998 3818
1999 3697
2000 3555
2001 3081
2002 3064
2003 3129
2004 3296
2005 3451
2006 3635
2007 3902
2008 4116
2009 4069
2010 4272
2011 4737
2012 5145
2013 5355
2014 5625
2015 5477
2016 5057
2017 4843
2018 4769
2019 2331
2020 51
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231,171 results
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Page 1
Immune Responses in the Liver.
Kubes P and Jenne C. Annu Rev Immunol 2018 - Review. PMID 29328785
The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering the body via the gut, the liver appears designed to detect, capture, and clear bacteria, viruses, and macromolecules. ...This balance between immunity and tolerance is essential to liver function. Excessive inflammation in the absence of infection leads to sterile liver injury, tissue damage, and remodeling; insufficient immunity allows for chronic infection and cancer. ...
The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering the body via the gut, the liver a …
The liver.
Trefts E, et al. Curr Biol 2017. PMID 29112863 Free PMC article.
The liver oxidizes lipids, but can also package excess lipid for secretion to and storage in other tissues, such as adipose. ...These processes that are fully developed in the mature liver are imperative for life. Liver failure from any number of sources (e.g. viral infection, overnutrition, or oncologic burden) is a global health problem. ...
The liver oxidizes lipids, but can also package excess lipid for secretion to and storage in other tissues, such as adipose. ...These …
Immune surveillance by the liver.
Jenne CN and Kubes P. Nat Immunol 2013 - Review. PMID 24048121
Receiving both portal vein blood and arterial blood, the liver is an important and critical component in the defense against blood-borne infection. ...It is this balance between activation and tolerance that characterizes the liver as a frontline immunological organ....
Receiving both portal vein blood and arterial blood, the liver is an important and critical component in the defense against blood-bo …
Apoptosis and necrosis in the liver.
Guicciardi ME, et al. Compr Physiol 2013 - Review. PMID 23720337 Free PMC article.
However, the minimal expression of a key player in this process in the liver suggests this form of cell death may be uncommon in liver diseases. Because apoptosis is a key feature of so many diseases of the liver, therapeutic modulation of liver cell death holds promise. ...
However, the minimal expression of a key player in this process in the liver suggests this form of cell death may be uncommon in l
Current approach to liver traumas.
Kaptanoglu L, et al. Int J Surg 2017. PMID 28193544 Free article.
INTRODUCTION: Liver injuries remain major obstacle for successful treatment, due to size and location of the liver. Requirement for surgery should be determined by clinical factors, most notably hemodynamical state. ...Our current approach to liver traumas is non operative technique, if possible....
INTRODUCTION: Liver injuries remain major obstacle for successful treatment, due to size and location of the liver. Requiremen …
Immune and metabolic shifts during neonatal development reprogram liver identity and function.
Nakagaki BN, et al. J Hepatol 2018. PMID 30171870
However, how the liver adapts both the immune system and enzymatic profile to challenges in the postnatal period remains elusive. ...CONCLUSION: In newborns, the immune and metabolic profiles of the liver are dramatically different to those of the adult liver, which can be explained by the differences in the liver cell repertoire and phenotype. ...
However, how the liver adapts both the immune system and enzymatic profile to challenges in the postnatal period remains elusive. ... …
Management of paediatric liver trauma.
van As AB and Millar AJ. Pediatr Surg Int 2017 - Review. PMID 28028561
Of all the intra-abdominal solid organs, the liver is the most vulnerable to blunt abdominal trauma. The majority of liver ruptures present in combination with other abdominal or extra-abdominal injuries. ...Penetrating liver injuries more often require operative intervention and are managed according to adult protocols. The greatest clinical challenge remains the timely identification of the severely damaged liver with immediate and aggressive resuscitation and expedition to laparotomy. ...
Of all the intra-abdominal solid organs, the liver is the most vulnerable to blunt abdominal trauma. The majority of liver rup …
Regulation of liver development: implications for liver biology across the lifespan.
Gruppuso PA and Sanders JA. J Mol Endocrinol 2016 - Review. PMID 26887388 Free PMC article.
Processes essential to the attainment of adequate liver mass and function during fetal life include cell lineage specification early in development, enzymic and other functional modes of differentiation throughout gestation, and ongoing cell proliferation to achieve adequate liver mass. ...In the aggregate, studies on the mechanisms governing fetal liver development have implications not only for the perinatal metabolic transition but also for the prevention and treatment of liver disorders throughout the lifespan....
Processes essential to the attainment of adequate liver mass and function during fetal life include cell lineage specification early …
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.
Friedman SL. Physiol Rev 2008 - Review. PMID 18195085 Free PMC article.
But this simple paradigm has now yielded to a remarkably broad appreciation of the cell's functions not only in liver injury, but also in hepatic development, regeneration, xenobiotic responses, intermediary metabolism, and immunoregulation. ...As interest in this cell type intensifies, more surprises and mysteries are sure to unfold that will ultimately benefit our understanding of liver physiology and the diagnosis and treatment of liver disease....
But this simple paradigm has now yielded to a remarkably broad appreciation of the cell's functions not only in liver injury, but als …
231,171 results
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