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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 10
1946 29
1947 36
1948 11
1949 8
1950 104
1951 204
1952 296
1953 458
1954 430
1955 546
1956 605
1957 566
1958 610
1959 605
1960 525
1961 546
1962 402
1963 503
1964 1086
1965 1454
1966 2193
1967 2598
1968 3219
1969 3579
1970 3373
1971 3855
1972 4381
1973 4406
1974 4627
1975 4574
1976 4370
1977 4227
1978 4217
1979 4399
1980 4499
1981 4404
1982 4572
1983 4641
1984 4858
1985 4875
1986 4688
1987 4631
1988 4419
1989 4680
1990 4905
1991 4834
1992 4638
1993 4720
1994 4657
1995 4595
1996 4484
1997 4282
1998 3968
1999 3950
2000 3944
2001 3512
2002 3476
2003 3706
2004 3804
2005 4151
2006 4323
2007 4404
2008 4534
2009 4546
2010 4907
2011 5481
2012 6021
2013 6151
2014 6046
2015 5882
2016 5645
2017 5305
2018 5219
2019 2465
2020 39
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236,732 results
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Page 1
Drug Metabolism in the Liver.
Almazroo OA, et al. Clin Liver Dis 2017 - Review. PMID 27842765
The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. ...
The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug …
Clinical pharmacokinetics of ethanol
Holford NH. Clin Pharmacokinet 1987 - Review. PMID 3319346
Elimination is principally by metabolism in the liver with small amounts excreted in the breath (0.7%), urine (0.3%), and sweat (0.1%). Metabolism occurs, principally by alcohol dehydrogenase, in the liver to acetaldehyde. Models of ethanol input and absorption are crucial to the description and understanding of the effects of ethanol dose on bioavailability. ...
Elimination is principally by metabolism in the liver with small amounts excreted in the breath (0.7%), urine (0.3%), and swea …
Human liver metabolism.
GRIFFITHS DB and REES KR. Br Med J 1957. PMID 13472023 Free PMC article.
Catalase and nonalcoholic fatty liver disease.
Shin SK, et al. Pflugers Arch 2018 - Review. PMID 30120555
Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver disease (NAFLD), and oxidative stress accelerates the progression of NAFLD. ...However, the relationship between NAFLD progression and antioxidants, particularly catalase, which is most commonly expressed in the liver, remains unclear. ...
Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver disease (NAFLD), and oxidative stress accel …
Regulation of enzymes of the urea cycle and arginine metabolism.
Morris SM. Annu Rev Nutr 2002 - Review. PMID 12055339
Glucagon, insulin, and glucocorticoids are major regulators of the expression of urea cycle enzymes in liver. In contrast, the "urea cycle" enzymes in nonhepatic cells are regulated by a wide range of pro- and antiinflammatory cytokines and other agents. ...This review emphasizes recent information regarding roles and regulation of urea cycle and arginine metabolic enzymes in liver and other cell types....
Glucagon, insulin, and glucocorticoids are major regulators of the expression of urea cycle enzymes in liver. In contrast, the "urea …
Glutamine metabolism and signaling in the liver.
Häussinger D and Schliess F. Front Biosci 2007 - Review. PMID 17127305
Hepatic glutamine metabolism in connection with urea synthesis is importantly involved in systemic ammonia detoxication and pH regulation due to the unique regulatory properties of the liver-type glutaminase, the acinar compartimentation of urea and glutamine synthesis, and a cycling of glutamine between periportal and perivenous hepatocytes. ...This review summarizes recent progress in the understanding of glutamine metabolism and signal transduction, which provides further rationale for the use of glutamine as a therapeutic tool....
Hepatic glutamine metabolism in connection with urea synthesis is importantly involved in systemic ammonia detoxication and pH regula …
Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage.
Powis G, et al. Drug Metab Dispos 1988. PMID 2903027
Surgical waste provided a good source of fresh, histologically normal, human liver for metabolism studies. Microsomal cytochrome P-450 content showed a significant increase with the age of the liver donor. Metabolism of benzo(a)pyrene to 3-hydroxybenzo(a)pyrene and benzo(a)pyrene-7,8- and -9,10-diols showed up to 136% higher rates in fresh liver microsomes from female donors....
Surgical waste provided a good source of fresh, histologically normal, human liver for metabolism studies. Microsomal cytochro …
Zonation of hepatic fatty acid metabolism - The diversity of its regulation and the benefit of modeling.
Schleicher J, et al. Biochim Biophys Acta 2015 - Review. PMID 25677822
In the last decades zonation patterns of liver metabolism were extensively investigated for carbohydrate, nitrogen and lipid metabolism. ...In the last part of the review, a short collection of models considering hepatic lipid metabolism is provided. We conclude that modeling, despite its proven benefit for understanding of hepatic carbohydrate and ammonia metabolisms, has so far been largely disregarded in the study of lipid metabolism; therefore some possible fields of modeling interest are presented....
In the last decades zonation patterns of liver metabolism were extensively investigated for carbohydrate, nitrogen and lipid …
"Hepatopancreas"?
van Weel PB. Comp Biochem Physiol A Comp Physiol 1974 - Review. PMID 4149001
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