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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 1
1968 3
1969 1
1970 3
1971 6
1972 4
1973 5
1974 2
1975 3
1976 6
1977 8
1978 8
1979 7
1980 10
1981 9
1982 5
1983 8
1984 10
1985 13
1986 9
1987 8
1988 17
1989 17
1990 9
1991 19
1992 21
1993 22
1994 22
1995 17
1996 18
1997 15
1998 14
1999 15
2000 21
2001 20
2002 21
2003 16
2004 16
2005 22
2006 21
2007 22
2008 20
2009 13
2010 14
2011 11
2012 13
2013 24
2014 19
2015 28
2016 18
2017 11
2018 16
2019 5
2020 0
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658 results
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Page 1
Heart and bile acids - Clinical consequences of altered bile acid metabolism.
Vasavan T, et al. Biochim Biophys Acta Mol Basis Dis 2018 - Review. PMID 29317337 Free article.
Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis such as primary biliary cholangitis and primary sclerosing cholangitis. ...Approximately 50% of liver cirrhosis cases develop cirrhotic cardiomyopathy. Bile acids are directly implicated in this, causing QT interval prolongation, cardiac hypertrophy, cardiomyocyte apoptosis and abnormal haemodynamics of the heart. ...
Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis such as primary biliary chol …
The metabolism of cholestanol in primary biliary cirrhosis.
Gylling H, et al. J Hepatol 1996. PMID 8738731
BACKGROUND/AIMS: The concentration of serum cholestanol, a 5 alpha-saturated derivative of cholesterol, is increased in primary biliary cirrhosis proportionally to impaired liver function for unknown reasons. The purpose of this study was to analyze serum cholestanol level and its biliary and fecal elimination, and relate the results to cholesterol absorption and metabolism. ...
BACKGROUND/AIMS: The concentration of serum cholestanol, a 5 alpha-saturated derivative of cholesterol, is increased in primary biliary
MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation.
Erice O, et al. Hepatology 2018. PMID 28922472 Free PMC article.
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). ...MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but its functional relevance is largely unknown. ...
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrah …
Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism.
Kohjima M, et al. Liver Int 2015. PMID 24620780
BACKGROUND & AIMS: Injury to biliary epithelial cells caused by disorders in bile composition may be the initial step in the pathogenesis of primary biliary cirrhosis (PBC). We therefore examined choline/phospholipid metabolism in livers of patients with PBC. METHODS: Hepatic levels of mRNA encoded by choline metabolism-related genes in early stage PBC patients were quantified by real-time RT-PCR. ...
BACKGROUND & AIMS: Injury to biliary epithelial cells caused by disorders in bile composition may be the initial step in the path …
Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis.
Van Campenhout S, et al. Methods Mol Biol 2019. PMID 31016658
Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. An extensively used experimental model to investigate the pathophysiology of biliary cirrhosis and potential novel therapies is the common bile duct ligation in mice and rats. ...
Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholang …
Role of Bile Acids and the Biliary HCO(3)(-) Umbrella in the Pathogenesis of Primary Biliary Cholangitis.
van Niekerk J, et al. Clin Liver Dis 2018 - Review. PMID 30259847
In primary biliary cholangitis, defects of the biliary HCO(3)(-) umbrella, leading to impaired biliary HCO(3)(-) secretion have been identified. Current medical therapies stabilize the putatively defective biliary HCO(3)(-) umbrella and improve long-term prognosis....
In primary biliary cholangitis, defects of the biliary HCO(3)(-) umbrella, leading to impaired biliary HCO(3)(-) secret …
Complement metabolism in chronic liver disease: catabolism of C1q in chronic active liver disease and primary biliary cirrhosis.
Potter BJ, et al. Gastroenterology 1980. PMID 7380176
The fractional catabolic rate of C1q was increased markedly in primary biliary cirrhosis, and in HBsAg-positive chronic liver disease. ...These data provide further evidence for the activation of the classical pathway of complement in primary biliary cirrhosis and HBsAg-positive chronic active liver disease. ...
The fractional catabolic rate of C1q was increased markedly in primary biliary cirrhosis, and in HBsAg-positive chronic liv
Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease.
Mawer EB, et al. Clin Sci (Lond) 1985. PMID 2996827
The metabolism of isotopically labelled vitamin D2 and D3 has been investigated in eight patients with primary biliary cirrhosis and in five controls. ...Vitamin D2-derived urinary radioactivity in primary biliary cirrhosis correlated strongly with serum bilirubin (P = 0.005). The metabolism of labelled vitamin D3 was studied in seven patients with alcoholic liver disease, three of whom showed low serum concentrations of labelled 25-hydroxyvitamin D3 suggesting impaired hepatic synthesis. ...
The metabolism of isotopically labelled vitamin D2 and D3 has been investigated in eight patients with primary biliary cirr
Differential effect of biliary and micronodular cirrhosis on oxidative drug metabolism. In vivo-in vitro correlations of dextromethorphan metabolism in rat models.
Roos FJ, et al. Biochem Pharmacol 1991. PMID 2018555
Oxidative drug metabolism is impaired in liver cirrhosis; it is unclear, however, whether this depends on the etiology of cirrhosis. Therefore, we studied the metabolism of dextromethorphan in two rat models: biliary cirrhosis induced by bile duct ligation and micronodular cirrhosis induced by chronic exposure to CCl4/phenobarbital. ...
Oxidative drug metabolism is impaired in liver cirrhosis; it is unclear, however, whether this depends on the etiology …
Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: an immunohistochemical study.
Joplin R, et al. Hepatology 1991. PMID 1714873
The distribution of the three pyruvate dehydrogenase complex subunits was examined in the liver and lymph nodes of patients with primary biliary cirrhosis, patients with other liver diseases and normal subjects by immunohistochemistry using affinity-purified antibodies. ...The increased intensity of E2 in primary biliary cirrhotic tissue could be explained in terms of abnormal metabolism of E2 by biliary epithelial cells....
The distribution of the three pyruvate dehydrogenase complex subunits was examined in the liver and lymph nodes of patients with prim …
658 results
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