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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 4
1967 3
1968 4
1969 3
1970 5
1971 1
1972 2
1973 7
1974 5
1975 4
1976 4
1977 6
1978 6
1979 4
1980 3
1981 9
1982 9
1983 7
1984 7
1985 6
1986 9
1987 13
1988 15
1989 9
1990 13
1991 5
1992 7
1993 12
1994 12
1995 13
1996 12
1997 11
1998 7
1999 14
2000 13
2001 14
2002 17
2003 21
2004 6
2005 16
2006 10
2007 13
2008 10
2009 8
2010 17
2011 18
2012 16
2013 15
2014 16
2015 16
2016 8
2017 7
2018 11
2019 2
2020 0
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484 results
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Page 1
Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.
Tsuneyama K, et al. J Med Invest 2017 - Review. PMID 28373632 Free article.
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease that predominantly affects middle-aged women and is characterized by the chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and, ultimately, fibrosis. ...A sign of fragility of biliary epithelial cells caused by apoptosis, senescence, and autophagy has also been noted. Several complex steps and mechanisms appear to be involved in the induction and progression of cholangitis and biliary degeneration in patients with PBC. ...
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease …
Extrahepatic Manifestations of Primary Biliary Cholangitis.
Chalifoux SL, et al. Gut Liver 2017 - Review. PMID 28292174 Free PMC article.
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis. ...
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of the intrahepatic …
Liver Biopsy in Primary Biliary Cholangitis: Indications and Interpretation.
Tan D and Goodman ZD. Clin Liver Dis 2018 - Review. PMID 30259854
Primary biliary cholangitis is a disease characterized by immune-mediated bile duct destruction, followed by inflammation, scarring, and the development of chronic cholestasis and a slow progression to cirrhosis over the course of years. Liver biopsy has traditionally been used in conjunction with clinical evaluation and serologic autoantibody testing to establish the diagnosis, but it is no longer required in typical cases with positive antimitochondrial antibodies. ...
Primary biliary cholangitis is a disease characterized by immune-mediated bile duct destruction, followed by inflammation, scarring, …
Primary Biliary Cholangitis and Autoimmune Hepatitis.
Gonzalez RS and Washington K. Surg Pathol Clin 2018 - Review. PMID 29751878
Primary biliary cholangitis and autoimmune hepatitis are common autoimmune diseases of the liver. Both have typical clinical presentations, including certain autoantibodies on serologic testing. ...First-line therapy is immunosuppression for autoimmune hepatitis and ursodeoxycholic acid for primary biliary cholangitis. Both diseases may progress to cirrhosis....
Primary biliary cholangitis and autoimmune hepatitis are common autoimmune diseases of the liver. Both have typical clinical p …
Blood and liver-infiltrating lymphocytes in primary biliary cirrhosis: increase in activated T and natural killer cells and recruitment of primed memory T cells.
Björkland A, et al. Hepatology 1991. PMID 2050330
Several significant differences were observed when blood and liver-infiltrating cells from primary biliary cirrhosis patients were compared. ...In liver tissue from other chronic liver disease subjects, a lower CD4/CD8 ratio was found compared with primary biliary cirrhosis....
Several significant differences were observed when blood and liver-infiltrating cells from primary biliary cirrhosis pa …
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, et al. Nat Commun 2018. PMID 29523787 Free PMC article.
We have developed a mouse model of biliary senescence, based on the conditional deletion of Mdm2 in bile ducts under the control of the Krt19 promoter, that exhibits features of biliary disease. ...Finally, we study how inhibition of TGFβ-signalling disrupts the transmission of senescence and restores liver function. We identify cellular senescence as a detrimental mechanism in the development of biliary injury. ...
We have developed a mouse model of biliary senescence, based on the conditional deletion of Mdm2 in bile ducts under the control of t …
Computerized morphometry of the cirrhotic liver: comparative analysis in primary biliary cirrhosis, alcoholic cirrhosis, and posthepatitic cirrhosis.
Vertemati M, et al. Microsc Res Tech 2004. PMID 15605407
Fibrosis and nodular regeneration are the hallmarks of liver cirrhosis. To assess the degree of fibrosis and the severity of the structural changes affecting parenchymal and extraparenchymal components in liver cirrhosis, a computerized morphometric model has been applied to liver specimens from patients undergoing liver transplantation for primary biliary cirrhosis, posthepatitic and alcoholic cirrhosis. Fifty-eight hepatectomy specimens from patients undergoing liver transplantation for cirrhosis were analyzed: 17 alcoholic, 28 posthepatitic (HBV-related and HCV-related cirrhosis), and 13 primary biliary cirrhoses. ...
Fibrosis and nodular regeneration are the hallmarks of liver cirrhosis. To assess the degree of fibrosis and the severity of t …
Evolution of our understanding of PBC
Tanaka A, et al. Best Pract Res Clin Gastroenterol 2018 - Review. PMID 30343708
The discovery of mitochondrial autoantigens recognized by antimitochondrial antibodies (AMAs) in 1987 marked the dawn of a new era in primary biliary cholangitis (PBC) research. ...Expanding our knowledge of the pathology from a very early stage of the disease will provide the key to cure PBC....
The discovery of mitochondrial autoantigens recognized by antimitochondrial antibodies (AMAs) in 1987 marked the dawn of a new era in primar …
Environmental basis of primary biliary cholangitis.
Tanaka A, et al. Exp Biol Med (Maywood) 2018 - Review. PMID 29307284 Free PMC article.
Primary biliary cholangitis, formally known as primary biliary cirrhosis, is considered a model autoimmune disease for which our group has extensively evaluated environmental factors involved in its etiology. ...Moreover, we found that C57BL/6 mice immunized with 2-octynoic acid-BSA possess many of the features characteristic to primary biliary cholangitis. ...
Primary biliary cholangitis, formally known as primary biliary cirrhosis, is considered a model autoimmune disease for …
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
Byun S, et al. Nat Commun 2018. PMID 29968724 Free PMC article.
Liver-specific expression of phospho-defective Y67F-FXR or Src downregulation in mice results in impaired homeostatic responses to acute BA feeding, and exacerbates cholestatic pathologies upon drug-induced hepatobiliary insults. Also, the hepatic FGF19-Src-FXR pathway is defective in primary biliary cirrhosis (PBC) patients. This study identifies Src-mediated FXR phosphorylation as a potential therapeutic target and biomarker for BA-related enterohepatic diseases....
Liver-specific expression of phospho-defective Y67F-FXR or Src downregulation in mice results in impaired homeostatic responses to ac
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