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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 6
1967 4
1968 12
1969 5
1970 8
1971 11
1972 15
1973 25
1974 14
1975 13
1976 15
1977 18
1978 17
1979 18
1980 23
1981 23
1982 27
1983 25
1984 24
1985 36
1986 27
1987 30
1988 35
1989 33
1990 33
1991 30
1992 37
1993 41
1994 40
1995 33
1996 40
1997 38
1998 31
1999 45
2000 47
2001 38
2002 48
2003 56
2004 35
2005 48
2006 55
2007 37
2008 57
2009 28
2010 55
2011 48
2012 47
2013 44
2014 43
2015 43
2016 24
2017 33
2018 33
2019 9
2020 1
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1,592 results
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Page 1
Current and promising therapy for primary biliary cholangitis.
Gossard AA and Lindor KD. Expert Opin Pharmacother 2019 - Review. PMID 30931642
INTRODUCTION: Primary biliary cholangitis is a chronic, cholestatic liver disease that may progress to cirrhosis with complications of end-stage liver disease. ...Ultimately, patients with PBC may end up requiring liver transplantation and referral to a transplant center may also be needed....
INTRODUCTION: Primary biliary cholangitis is a chronic, cholestatic liver disease that may progress to cirrhosis with c …
Microwave Ablation: The Differences Between Biliary Cirrhosis and Normal Porcine Liver Using a Cooled-tip Electrode.
Wang LG, et al. Anticancer Res 2016. PMID 26977018
AIM: To elucidate the difference in both in vivo and ex vivo microwave ablation in a biliary cirrhotic porcine liver model using a cooled-tip electrode. ...CONCLUSION: Both in vivo and ex vivo ablated areas in biliary cirrhotic pig liver were smaller than their counterparts in normal liver, suggesting that for the same amount of power, it requires a significantly longer duration to achieve the same ablated volume in cirrhotic liver compared to normal liver....
AIM: To elucidate the difference in both in vivo and ex vivo microwave ablation in a biliary cirrhotic porcine liver model usi …
Liver Biopsy in Primary Biliary Cholangitis: Indications and Interpretation.
Tan D and Goodman ZD. Clin Liver Dis 2018 - Review. PMID 30259854
Primary biliary cholangitis is a disease characterized by immune-mediated bile duct destruction, followed by inflammation, scarring, and the development of chronic cholestasis and a slow progression to cirrhosis over the course of years. Liver biopsy has traditionally been used in conjunction with clinical evaluation and serologic autoantibody testing to establish the diagnosis, but it is no longer required in typical cases with positive antimitochondrial antibodies. ...
Primary biliary cholangitis is a disease characterized by immune-mediated bile duct destruction, followed by inflammation, scarring, …
Evolution of our understanding of PBC
Tanaka A, et al. Best Pract Res Clin Gastroenterol 2018 - Review. PMID 30343708
The discovery of mitochondrial autoantigens recognized by antimitochondrial antibodies (AMAs) in 1987 marked the dawn of a new era in primary biliary cholangitis (PBC) research. ...Expanding our knowledge of the pathology from a very early stage of the disease will provide the key to cure PBC....
The discovery of mitochondrial autoantigens recognized by antimitochondrial antibodies (AMAs) in 1987 marked the dawn of a new era in primar …
Detection of male DNA in the liver of female patients with primary biliary cirrhosis.
Fanning PA, et al. J Hepatol 2000. PMID 11097474
BACKGROUND/AIMS: Primary biliary cirrhosis is a chronic cholestatic liver disease characterized by progressive inflammatory destruction of bile ducts, with eventual hepatic fibrosis and cirrhosis. ...CONCLUSIONS: The presence of male cells in the liver of women with primary biliary cirrhosis raises the possibility that fetal cell microchimerism may be involved in the pathogenesis of this chronic liver disease....
BACKGROUND/AIMS: Primary biliary cirrhosis is a chronic cholestatic liver disease characterized by progressive inflamma …
Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis.
Van Campenhout S, et al. Methods Mol Biol 2019. PMID 31016658
Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. An extensively used experimental model to investigate the pathophysiology of biliary cirrhosis and potential novel therapies is the common bile duct ligation in mice and rats. ...
Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholang …
Recurrence of primary biliary cirrhosis, autoimmune cholangitis and primary sclerosing cholangitis after liver transplantation.
Batts KP and Wang X. Clin Liver Dis 1998 - Review. PMID 15560041
Given the usually prolonged natural history of primary biliary cirrhosis, autoimmune cholangitis, and primary sclerosing cholangitis, and the relatively recent introduction of orthotopic liver transplantation, our understanding of recurrence of these autoimmune diseases after orthotopic liver transplantation has been slow to evolve. Present data suggest that after orthotopic liver transplantation, patients with primary biliary cirrhosis will have persistence of serum antimitochondrial antibodies, develop histologic lesions suggestive of recurrent primary biliary cirrhosis with a frequency in the 8% to 16% range at 2 to 5 years after orthotopic liver transplantation, but will demonstrate little if any symptomatic disease as a consequence. ...
Given the usually prolonged natural history of primary biliary cirrhosis, autoimmune cholangitis, and primary sclerosing chola …
Biliary epithelial cells from the liver of patients with primary biliary cirrhosis: isolation, characterization, and short-term culture.
Joplin R, et al. J Pathol 1990. PMID 2266463
Since biliary epithelial cells of the middle-sized interlobular bile ducts are targets for lymphocyte-mediated damage in patients with primary biliary cirrhosis (PBC), we have developed a method for isolating and maintaining these cells in short-term tissue culture. ...By these criteria cells were judged to be identical to biliary epithelial cells from normal liver. The cells could be maintained in short-term tissue culture for up to 4 weeks without loss of biliary epithelial cell markers. ...
Since biliary epithelial cells of the middle-sized interlobular bile ducts are targets for lymphocyte-mediated damage in patients wit …
Eosinophilic infiltration of the liver in primary biliary cirrhosis: a morphological study.
Terasaki S, et al. Hepatology 1993. PMID 8428717
In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary biliary cirrhosis. ...Eosinophilic infiltration of the portal tracts may play a role in immunological injuries of the interlobular bile ducts in primary biliary cirrhosis....
In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary b
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