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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 1
1969 3
1970 3
1971 1
1972 2
1973 4
1974 3
1975 2
1976 5
1977 2
1978 1
1979 1
1980 2
1981 3
1982 2
1983 3
1984 6
1985 9
1986 3
1987 5
1988 10
1989 6
1990 13
1991 12
1992 12
1993 14
1994 18
1995 22
1996 8
1997 20
1998 17
1999 18
2000 17
2001 14
2002 20
2003 17
2004 18
2005 24
2006 12
2007 16
2008 22
2009 21
2010 34
2011 17
2012 10
2013 19
2014 13
2015 11
2016 8
2017 8
2018 12
2019 1
2020 0
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521 results
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Page 1
Fibrates and cholestasis
Ghonem NS, et al. Hepatology 2015 - Review. PMID 25678132 Free PMC article.
Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production and causes intracellular retention of toxic bile constituents, including bile salts. If left untreated, cholestasis leads to liver fibrosis and cirrhosis, which eventually results in liver failure and the need for liver transplantation. ...
Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disrup …
[PRIMARY BILIARY LIVER CIRRHOSIS: MODERN CONCEPTS].
Tsimmerman YS. Klin Med (Mosk) 2015 - Review. PMID 26596052 Russian.
Modern data on primary biliary liver cirrhosis are presented including the definition, prevalence, possible etiological factors, and detailed description of pathogenesis (autoimmune mechanisms, intrahepatic cholestasis, hereditary predisposition, environmental factors) and clinical picture. Also considered are complications and concomitant diseases, methods of laboratory, instrumental and morphological diagnostics, approaches to medicamental treatment and its effectiveness, indications for liver transplantation....
Modern data on primary biliary liver cirrhosis are presented including the definition, prevalence, possible etiological factor …
Pathophysiology of primary biliary cholangitis
Gulamhusein AF and Hirschfield GM. Best Pract Res Clin Gastroenterol 2018 - Review. PMID 30343706
In a genetically susceptible host, multi-lineage loss of tolerance to the E2 component of the 2-oxo-dehydrogenase pathway and dysregulated immune pathways directed at biliary epithelial cells leads to cholestasis, progressive biliary fibrosis, and cirrhosis in a subset of patients. ...
In a genetically susceptible host, multi-lineage loss of tolerance to the E2 component of the 2-oxo-dehydrogenase pathway and dysregulated i …
Environmental basis of primary biliary cholangitis
Tanaka A, et al. Exp Biol Med (Maywood) 2018 - Review. PMID 29307284 Free PMC article.
Primary biliary cholangitis, formally known as primary biliary cirrhosis, is considered a model autoimmune disease for which our group has extensively evaluated environmental factors involved in its etiology. ...
Primary biliary cholangitis, formally known as primary biliary cirrhosis, is considered a model autoimmune disease for which our grou …
Gut-liver axis: an immune link between celiac disease and primary biliary cirrhosis.
Volta U, et al. Expert Rev Gastroenterol Hepatol 2013 - Review. PMID 23445234
The association between celiac disease and primary biliary cirrhosis is well established. The breakdown of gut-liver axis equilibrium plays a central role in the development of immune disorders involving the small bowel and liver. ...An aberrant intestinal T lymphocyte homing to the liver may contribute to trigger immune hepatic damage. Both celiac disease and primary biliary cirrhosis share several features, including a higher prevalence in females, autoimmune comorbidities and specific autoantibodies. ...
The association between celiac disease and primary biliary cirrhosis is well established. The breakdown of gut-liver axis equi …
Symptoms of PBC - Pathophysiology and management
Khanna A, et al. Best Pract Res Clin Gastroenterol 2018 - Review. PMID 30343709
Primary biliary cholangitis is a chronic cholestatic liver disease characterised by progressive bile duct damage and, ultimately, biliary cirrhosis. ...
Primary biliary cholangitis is a chronic cholestatic liver disease characterised by progressive bile duct damage and, ultimately, bil …
Liver abnormalities in connective tissue diseases.
De Santis M, et al. Best Pract Res Clin Gastroenterol 2013 - Review. PMID 24090941
The liver is a lymphoid organ involved in the immune response and in the maintenance of tolerance to self molecules, but it is also a target of autoimmune reactions, as observed in primary liver autoimmune diseases (AILD) such as autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. ...Although liver cirrhosis and failure are extremely rare in patients with CTD, unusual liver conditions such as nodular regenerative hyperplasia or Budd-Chiari syndrome have been reported with increasing frequency in patients with CTD. ...
The liver is a lymphoid organ involved in the immune response and in the maintenance of tolerance to self molecules, but it is also a …
Primary biliary cirrhosis.
Bhandari BM, et al. Gastroenterol Clin North Am 2011 - Review. PMID 21601785
Primary biliary cirrhosis is a chronic autoimmune inflammatory disease of the liver with a striking female preponderance. It has an insidious onset and typically affects middle-aged women. ...The standard treatment for primary biliary cirrhosis is ursodeoxycholic acid, which improves survival, but the disease can still lead to cirrhosis and liver failure over decades....
Primary biliary cirrhosis is a chronic autoimmune inflammatory disease of the liver with a striking female preponderance. It h …
Smoking as a risk factor for autoimmune liver disease: what we can learn from primary biliary cirrhosis.
Smyk DS, et al. Ann Hepatol 2012 - Review. PMID 22166556 Free article.
Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. ...Studies of smoking in liver disease have also shown that smoking may progress the disease towards fibrosis and subsequent cirrhosis. ...
Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the immune-mediated destruction of biliary epi …
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