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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 5
1968 2
1969 4
1970 1
1971 3
1972 5
1974 5
1975 4
1976 3
1977 2
1978 5
1979 1
1980 1
1981 1
1982 1
1983 5
1984 1
1985 2
1986 4
1987 8
1988 5
1989 8
1990 7
1991 6
1992 6
1993 4
1994 6
1995 10
1996 8
1997 8
1998 9
1999 9
2000 10
2001 6
2002 10
2003 8
2004 8
2005 13
2006 11
2007 4
2008 8
2009 6
2010 6
2011 10
2012 5
2013 9
2014 6
2015 13
2016 6
2017 2
2018 5
2019 2
2020 0
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282 results
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Page 1
Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis.
Qu C, et al. Hepatology 2018. PMID 29537660 Free PMC article.
We sought to investigate the mechanism by which SYK promotes liver fibrosis and to evaluate SYK as a therapeutic target for liver fibrosis. ...The effects of SYK antagonism on liver fibrogenesis were studied in LX-2 cells, TWNT-4 cells, primary human HSCs, and three progressive fibrosis/cirrhosis animal models, including a CCL(4) mouse model, and diethylnitrosamine (DEN) and bile duct ligation (BDL) rat models. ...
We sought to investigate the mechanism by which SYK promotes liver fibrosis and to evaluate SYK as a therapeutic target for liver
Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats.
Cruz A, et al. J Pineal Res 2005. PMID 16098091
Liver cirrhosis is a critical stage of chronic liver diseases that can produce liver failure, portal hypertension and hepatocarcinoma. Sustained oxidative stress plays a key role in cell damage and fibrosis induced during liver cirrhosis. We evaluated the effect of oxidative stress regulation by melatonin on the development of parenchymal destruction and stellate cell activation in experimental liver cirrhosis. ...
Liver cirrhosis is a critical stage of chronic liver diseases that can produce liver failure, portal hypertensio
Elevated serum dipeptidyl peptidase IV (CD26, EC 3.4.14.5) activity in experimental liver cirrhosis.
Lakatos PL, et al. Eur J Clin Invest 2000. PMID 10998079
Aberrant DPP IV expression was found in human liver cirrhosis, and elevated serum DPP IV activity was reported in patients with primary biliary cirrhosis and chronic hepatitis C virus infection. The aim of the study was to examine serum DPP IV activity in experimental liver cirrhosis. METHODS: Liver cirrhosis was induced by administering diethyl-nitrosamine, phenobarbital and CCl4 in Fischer-344 male rats (n = 22). ...
Aberrant DPP IV expression was found in human liver cirrhosis, and elevated serum DPP IV activity was reported in patients wit …
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Rudolph KL, et al. Science 2000. PMID 10678830 Free article.
Accelerated telomere loss has been proposed to be a factor leading to end-stage organ failure in chronic diseases of high cellular turnover such as liver cirrhosis. ...Telomere dysfunction was associated with defects in liver regeneration and accelerated the development of liver cirrhosis in response to chronic liver injury. ...
Accelerated telomere loss has been proposed to be a factor leading to end-stage organ failure in chronic diseases of high cellular turnover …
Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway.
Ding Q, et al. Hum Pathol 2018. PMID 29514109
Propranolol is known to reduce portal pressure by decreasing blood flow to the splanchnic circulation and the liver. However, it is unknown if propranolol improves fibrogenesis and sinusoidal remodeling in the cirrhotic liver. ...In this study, a hepatic cirrhosis mouse model was induced by CCl(4) administration for 6 weeks. Propranolol was simultaneously administered orally in the experimental group. ...
Propranolol is known to reduce portal pressure by decreasing blood flow to the splanchnic circulation and the liver. However, it is u …
Liver metabolic zonation and hepatic microcirculation in carbon tetrachloride-induced experimental cirrhosis.
Gaudio E, et al. Dig Dis Sci 1997. PMID 9009134
Moreover, the microcirculation, a fundamental component in liver structure, shows dramatic changes in cirrhosis that would heavily influence the development of the disease. In order to determine the importance of the microvascular alterations on liver morphofunctional features in experimentally induced cirrhosis, their relationships with structural, ultrastructural, and histoenzymological hepatocyte modifications were investigated. ...
Moreover, the microcirculation, a fundamental component in liver structure, shows dramatic changes in cirrhosis that would hea …
Effects of protein deficiency on liver trace elements and antioxidant activity in carbon tetrachloride-induced liver cirrhosis.
González-Reimers E, et al. Biol Trace Elem Res 2003. PMID 12835497
In liver cirrhosis, liver tissue becomes progressively substituted by fibrosis, ultimately leading to architectural distortion, liver circulatory changes, and liver failure. ...GPX, SOD, and lipid peroxidation products as well as Zn, Cu, Mn, Se, and Fe were determined in liver samples. We found that liver GPX and Se were reduced in the cirrhotic animals, especially in the low-protein-fed ones, protein deficiency, but not cirrhosis, exerting the main effects. ...
In liver cirrhosis, liver tissue becomes progressively substituted by fibrosis, ultimately leading to architectural dis …
Zinc supplementation reduces blood ammonia and increases liver ornithine transcarbamylase activity in experimental cirrhosis.
Riggio O, et al. Hepatology 1992. PMID 1505922
Regardless of zinc supplementation, all carbon tetrachloride-treated rats exhibited similar micronodular cirrhosis, with similar histological appearance and liver function impairment. Cirrhotic rats without zinc supplementation showed high plasma ammonia and low serum and hepatic zinc levels and reduced liver ornithine transcarbamylase activity. ...
Regardless of zinc supplementation, all carbon tetrachloride-treated rats exhibited similar micronodular cirrhosis, with similar hist …
DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis
Yang JJ, et al. Toxicol Lett 2018. PMID 30010033
Hepatic stellate cells (HSCs) activation is considered as a pivotal event in liver fibrosis. In HSCs activation and fibrosis, epigenetic events are important. ...These data connect HSCs activation with a DNMT1-LncRNA H19 epigenetic pathway that is important for liver fibrosis....
Hepatic stellate cells (HSCs) activation is considered as a pivotal event in liver fibrosis. In HSCs activation and fibrosis, epigene …
Collagenase in experimental carbon tetrachloride cirrhosis of the liver.
Montfort I and Pérez-Tamayo R. Am J Pathol 1978. PMID 209692 Free PMC article.
The presence and distribution of collagenase in experimental CCl4 cirrhosis of the liver in rats has been studied by immunohistochemical techniques. A monospecific anti-rat uterus collagenase antibody was raised in rabbits and used for indirect immunofluorescence staining of liver sections obtained from rats in both the reversible and irreversible stages of CCl4-induced cirrhosis. ...
The presence and distribution of collagenase in experimental CCl4 cirrhosis of the liver in rats has been studied by immunohis …
282 results
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