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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1948 1
1951 24
1952 49
1953 41
1954 42
1955 35
1956 42
1957 52
1958 54
1959 55
1960 62
1961 58
1962 48
1964 8
1965 62
1966 111
1967 117
1968 140
1969 193
1970 153
1971 138
1972 141
1973 143
1974 129
1975 98
1976 102
1977 101
1978 125
1979 128
1980 110
1981 120
1982 149
1983 143
1984 117
1985 162
1986 158
1987 154
1988 172
1989 200
1990 230
1991 220
1992 243
1993 264
1994 296
1995 286
1996 308
1997 297
1998 327
1999 368
2000 343
2001 340
2002 418
2003 447
2004 453
2005 558
2006 572
2007 537
2008 656
2009 651
2010 726
2011 725
2012 755
2013 826
2014 891
2015 936
2016 920
2017 940
2018 1005
2019 473
2020 15
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18,705 results
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Page 1
Simvastatin Attenuates Liver Injury in Rodents with Biliary Cirrhosis Submitted to Hemorrhage/Resuscitation.
Meireles CZ, et al. Shock 2017. PMID 27559696
In conclusion, H/R aggravates liver microvascular dysfunction in cirrhosis, and upregulates liver inflammatory pathways. This does not occur in control livers. Simvastatin prevented H/R-induced liver endothelial dysfunction, and attenuated liver injury and liver inflammatory response, suggesting that it might have potential for protecting the cirrhotic liver during bleeding complications....
In conclusion, H/R aggravates liver microvascular dysfunction in cirrhosis, and upregulates liver inflammatory pathways …
Reversal of liver fibrosis: From fiction to reality.
Zoubek ME, et al. Best Pract Res Clin Gastroenterol 2017 - Review. PMID 28624101
It can progress to cirrhosis that is characterized by parenchymal and vascular architectural changes together with the presence of regenerative nodules. ...A better insight into the liver fibrogenesis resulted in a large number of clinical trials aiming at reversing liver fibrosis, particularly in patients with non-alcoholic steatohepatitis. ...
It can progress to cirrhosis that is characterized by parenchymal and vascular architectural changes together with the presence of re …
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
Coll M, et al. Cell Stem Cell 2018. PMID 30049452 Free article.
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources for relevant cell types, such as hepatic stellate cells (HSCs). ...Thus, this protocol provides a robust in vitro system for studying HSC development, modeling liver fibrosis, and drug toxicity screening....
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources fo …
Liver fibrosis: Common mechanisms and antifibrotic therapies.
Schuppan D. Clin Res Hepatol Gastroenterol 2015 - Review. PMID 26189980
Liver fibrosis and in particular cirrhosis have become major endpoints in clinical trials of patients with chronic liver diseases. ...We have made great progress in our understanding of the mechanisms and the cell biology of liver fibrosis and have already made the transition from preclinical testing of antifibrotic agents and strategies towards clinical translation. ...
Liver fibrosis and in particular cirrhosis have become major endpoints in clinical trials of patients with chronic liver
Nurse-led clinic for patients with liver cirrhosis-effects on health-related quality of life: study protocol of a pragmatic multicentre randomised controlled trial.
Hjorth M, et al. BMJ Open 2018 - Clinical Trial. PMID 30337316 Free PMC article.
INTRODUCTION: Liver cirrhosis affects health-related quality of life (HRQoL) even in its early stages. Morbidity is especially high when the disease decompensates and self-care actions become essential. ...Eligible patients are adults with diagnosed cirrhosis of the liver (n=500). Participants are randomised into either an intervention with nurse-led follow-up group or into a standard of care group. ...
INTRODUCTION: Liver cirrhosis affects health-related quality of life (HRQoL) even in its early stages. Morbidity is especially …
Patient-reported outcomes in cirrhosis: A scoping review of the literature.
Tapper EB, et al. Hepatology 2018 - Review. PMID 29272043 Free article.
The members of the American Association for the Study of Liver Diseases Practice Metrics Committee, charged with developing quality indicators for clinical practice, performed a scoping review of PROs in cirrhosis. ...These included clinical factors (severity of liver disease and its complications, medication burden, and comorbidities), specific PROs (cramps, pruritis), and surrogate outcome measures (falls, hospitalization). ...
The members of the American Association for the Study of Liver Diseases Practice Metrics Committee, charged with developing quality i …
[Nutritional care for patients with liver cirrhosis].
Aceves-Martins M. Nutr Hosp 2014 - Review. PMID 24528340 Spanish. Free article.
The liver is an important organ with specific functions that influence directly on the nutritional and physiological status of every person. At the presence of any illness or injury in this organ, liver cirrhosis is always its final phase. In this pathology, patients present carbohydrate utilization and storage diminishment, as well as protein and fat catabolism increase. ...
The liver is an important organ with specific functions that influence directly on the nutritional and physiological status of every …
Therapeutic effect of Soshiho-tang, a traditional herbal formula, on liver fibrosis or cirrhosis in animal models: a systematic review and meta-analysis.
Kim JH, et al. J Ethnopharmacol 2014 - Review. PMID 24727191
ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis has been recognized as a major lesion of the liver that leads to liver cirrhosis at the end stage. Soshiho-tang (SST) has been used to improve liver fibrosis/cirrhosis by ameliorating fibrosis-specific markers. This study aimed to assess the efficacy of SST on liver fibrosis/cirrhosis through a systematic review of the literature and meta-analysis using animal models. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis has been recognized as a major lesion of the liver that leads to liver
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